Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 37 clinical trials
Alpha/Beta T and CD19+ Depleted Peripheral Stem Cells for Patients With Primary Immunodeficiencies

This is a Phase II trial to determine the ability of a reduced intensity conditioning regimen to allow successful engraftment with alpha/beta T and CD19+ depleted peripheral stem cell grafts from unrelated or partially matched related donors. There are two conditioning regimens depending upon patient diagnosis and age.

reduced intensity conditioning
stem cell transplantation
histiocytosis
severe combined immunodeficiency
shortening fraction
  • 3 views
  • 24 Jan, 2021
  • 1 location
Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders

This study is designed to estimate the efficacy and toxicity of familial HLA mismatched bone marrow transplants in patients with non-malignant disease who are less than 21 years of age and could benefit from the procedure.

reduced intensity conditioning
blood transfusion
stroke
direct bilirubin
iron
  • 18 views
  • 26 Jan, 2021
  • 1 location
Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors

This phase I trial studies the safety of transplantation with a haploidentical donor peripheral blood stem cell graft depleted of TCR+ cells and CD19+ cells in conjunction with the immunomodulating drug, Zoledronate, given in the post-transplant period to treat pediatric patients with relapsed or refractory hematologic malignancies or high risk …

  • 0 views
  • 20 Mar, 2021
  • 1 location
Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMT CTN 1507)

This is a Phase II, single arm, multi-center trial, designed to estimate the efficacy and toxicity of haploidentical bone marrow transplantation (BMT) in patients with sickle cell disease (SCD). Based on their age and entry criteria patients are stratified into two groups: (1) children with SCD with strokes; and (2) …

transcranial doppler ultrasonography
blood transfusion
stroke
thalassemia
iron
  • 201 views
  • 24 Sep, 2021
  • 28 locations
Reduced Intensity Transplantation for Severe Sickle Cell Disease

This study is being done to test a transplant method that may have fewer side effects (or less toxic, less harmful) than conventional high dose chemotherapy conditioning-based transplants for children and young adults with Sickle Cell Disease (SCD). Patients less than or equal to 25 years old with SCD who …

transcranial doppler ultrasonography
plerixafor
sickle cell trait
opiates
stroke
  • 0 views
  • 12 May, 2021
  • 1 location
Study of a Geriatric Assessment to Plan a Treatment Approach for Older People With Various Blood Disorders

This study will evaluate whether a geriatric assessment can lead to better treatment outcomes in older patients (age 60+) with a myeloid malignancy including acute myeloid leukemia, ,myelodysplastic syndromes, myeloproliferative neoplasms, or related blood disorders who are going to receive chemotherapy or another treatment to prepare the body for an …

myelomonocytic leukemia
myeloid leukemia
chronic myeloid leukemia
leukemia
chronic myelomonocytic leukemia
  • 0 views
  • 27 May, 2021
  • 7 locations
A Study Evaluating Temferon in Patients With Glioblastoma & Unmethylated MGMT

This is a non-randomized, open label, phase I/IIa, dose-escalation study, involving a single injection of Temferon, an investigational advanced therapy consisting of autologous CD34+-enriched hematopoietic stem and progenitor cells exposed to transduction with a lentiviral vector driving myeloid specific interferon-alpha2 expression, which will be administered to up to 21 patients …

  • 0 views
  • 18 Feb, 2021
  • 3 locations
Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant

This phase II trial studies how well naive T-cell depletion works in preventing chronic graft-versus-host disease in children and young adults with blood cancers undergoing donor stem cell transplant. Sometimes the transplanted white blood cells from a donor attack the body's normal tissues (called graft versus host disease). Removing a …

lymphoid leukemia
cancer
thiotepa
hla-a
tacrolimus
  • 9 views
  • 03 Sep, 2021
  • 10 locations
Umbilical Cord Blood Transplant Cyclophosphamide Fludarabine and Total-Body Irradiation in Treating Patients With Hematologic Disease

This phase II trial studies how well giving an umbilical cord blood transplant together with cyclophosphamide, fludarabine, and total-body irradiation (TBI) works in treating patients with hematologic disease. Giving chemotherapy, such as cyclophosphamide and fludarabine, and TBI before a donor umbilical cord blood transplant helps stop the growth of cancer …

abnormal cells
lymphoid leukemia
myelodysplasia
thiotepa
white blood cells
  • 125 views
  • 22 Aug, 2021
  • 3 locations
Provision of TCR T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Na ve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation

This study seeks to examine treatment therapy that will reduced regimen-related toxicity and relapse while promoting rapid immune reconstitution with limited serious graft-versus-host-disease (GVHD) and also improve disease-free survival and quality of life. The investigators propose to evaluate the safety and efficacy of selective naive T-cell depleted (by TCR and …

antithymocyte globulin
cancer
colony stimulating factor
thiotepa
leukemia
  • 189 views
  • 04 Feb, 2021
  • 1 location