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Found 37 clinical trials
Evaluation of 2 Intensification Treatment Strategies for Neuroblastoma Patients With a Poor Response to Induction

The main objective is to evaluate the efficacy of two intensified consolidation strategies in very-high risk neuroblastoma (VHR-NBL) patients in terms of event-free survival from randomisation date. This evaluation will follow a hierarchical testing procedure: each experimental treatment will be first evaluated as a single-arm phase 2 study, and in …

  • 1 views
  • 11 Jun, 2021
  • 2 locations
A Trial of Treatments to Assess the Effects on Outcome of Adults With AML and MDS Undergoing Allogeneic SCT

Treatment options for older adults with Acute Myeloid Leukaemia (AML) and Myelodysplasia (MDS) are limited. Although stem cell transplantation remains one of the most effective treatments it is associated with severe side effects which have until recently prevented its use in older adults. In the last decade the use of …

cell transplantation
myelodysplasia
blast cells
myeloid leukemia
hla-a
  • 0 views
  • 24 Jan, 2021
  • 1 location
ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)

Pharmacogenomics (PG) offers the opportunity to individualize treatment according to patient genetic variations which influence activity of enzyme metabolizing or acting in the pathway of prescribed chemotherapy drugs. This add-on research aims to prospectively investigate variations in several candidate genes related to all types of chemotherapeutic drugs and TBI used …

lymphoid leukemia
remission
cell transplantation
cancer
b-cell acute lymphoblastic leukemia
  • 13 views
  • 23 Jan, 2021
  • 8 locations
High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

This is an international multicenter, open-label, randomized phase III trial including three sequential randomizations to assess efficacy of induction and consolidation chemotherapies and radiotherapy for patients with high-risk neuroblastoma.

  • 1 views
  • 12 Jun, 2021
  • 3 locations
Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or Ganglioneuroblastoma

This phase III trial studies iobenguane I-131 or crizotinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Crizotinib may stop the growth of tumor cells by blocking …

iobenguane
tumor cells
bone marrow procedure
vincristine
conventional surgery
  • 66 views
  • 29 Jul, 2021
  • 104 locations
Haplo vs. URD in AML

This study compares haplo-identical family donor stem cell transplantation (haplo SCT) to matched unrelated donor transplantation (URD SCT) in adult patients with acute myeloid leukemia (AML) with the hypothesis that haplo SCT is as good as URD SCT. Background A haplo-identical family donor is a relative sharing 50% of the …

graft versus host disease
cell transplantation
cyclophosphamide
busulfan
mycophenolate mofetil
  • 4 views
  • 23 Jan, 2021
  • 14 locations
TEAM (Thiotepa Etoposide Cytosar Melphalan ) for AutoSCT in Lymphoma

Study is designed to explore whether the introduction of Thiotepa, to the pre autologous stem-cell transplantation (ASCT) conditioning will reduce toxicity and thus improve outcome following

etoposide
cell transplantation
melphalan
hodgkin's disease
thiotepa
  • 0 views
  • 25 Jan, 2021
  • 1 location
Thiotepa Plus Fludarabine+ Melphalan as the Preparative Regime for Alternative Donor Transplantation

In the United States, thiotepa has been utilized in reduced intensity conditioning regimens for alternative donor courses (double umbilical cord blood transplant (dUCBT) and haplo-identical

lymphoma
lymphoid leukemia
myeloid leukemia
hematologic malignancy
hodgkin's disease
  • 12 views
  • 01 Jul, 2021
  • 1 location
Donor Stem Cell Transplant With Treosulfan Fludarabine and Thiotepa in Treating Patients With Non-malignant Disorders

This phase II trial studies how well donor stem cell transplant, treosulfan, fludarabine, and thiotepa work in treating patients with non-cancerous disorders. Giving chemotherapy before a donor

bone marrow procedure
primary cancer
  • 0 views
  • 20 May, 2021
  • 2 locations
Administration of High Dose Thiotepa and Melphalan With Autologous Hematopoietic Stem Cell Transplant in Children and Adolescents With Solid Tumors

recur. We propose a regimen of high dose thiotepa and melphalan followed by rescue of the patient's previously stored hematopoietic (blood manufacturing) system with blood stem cells. The aim

thiotepa
solid neoplasm
melphalan
solid tumour
high dose chemotherapy
  • 4 views
  • 07 Nov, 2020
  • 1 location