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Found 37 clinical trials
A Trial of Treatments to Assess the Effects on Outcome of Adults With AML and MDS Undergoing Allogeneic SCT

Treatment options for older adults with Acute Myeloid Leukaemia (AML) and Myelodysplasia (MDS) are limited. Although stem cell transplantation remains one of the most effective treatments it is associated with severe side effects which have until recently prevented its use in older adults. In the last decade the use of …

busulfan
consolidation therapy
leukemia
hla-a
secondary acute myeloid leukemia
  • 0 views
  • 24 Jan, 2021
  • 1 location
ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)

Pharmacogenomics (PG) offers the opportunity to individualize treatment according to patient genetic variations which influence activity of enzyme metabolizing or acting in the pathway of prescribed chemotherapy drugs. This add-on research aims to prospectively investigate variations in several candidate genes related to all types of chemotherapeutic drugs and TBI used …

chemotherapy drug
cell transplantation
busulfan
remission
b-cell acute lymphoblastic leukemia
  • 13 views
  • 23 Jan, 2021
  • 8 locations
High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

This is an international multicenter, open-label, randomized phase III trial including three sequential randomizations to assess efficacy of induction and consolidation chemotherapies and radiotherapy for patients with high-risk neuroblastoma.

  • 1 views
  • 06 Mar, 2021
  • 1 location
Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or Ganglioneuroblastoma

This phase III trial studies iobenguane I-131 or crizotinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Crizotinib may stop the growth of tumor cells by blocking …

carboplatin
stem cell transplantation
high-risk neuroblastoma
thiotepa
iobenguane
  • 66 views
  • 31 Mar, 2021
  • 99 locations
Haplo vs. URD in AML

This study compares haplo-identical family donor stem cell transplantation (haplo SCT) to matched unrelated donor transplantation (URD SCT) in adult patients with acute myeloid leukemia (AML) with the hypothesis that haplo SCT is as good as URD SCT. Background A haplo-identical family donor is a relative sharing 50% of the …

cell transplantation
cyclophosphamide
busulfan
mycophenolate mofetil
graft versus host disease
  • 4 views
  • 23 Jan, 2021
  • 14 locations
TEAM (Thiotepa Etoposide Cytosar Melphalan ) for AutoSCT in Lymphoma

Study is designed to explore whether the introduction of Thiotepa, to the pre autologous stem-cell transplantation (ASCT) conditioning will reduce toxicity and thus improve outcome following

cell transplantation
melphalan
etoposide
thiotepa
hodgkin's disease
  • 0 views
  • 25 Jan, 2021
  • 1 location
Thiotepa Plus Fludarabine+ Melphalan as the Preparative Regime for Alternative Donor Transplantation

In the United States, thiotepa has been utilized in reduced intensity conditioning regimens for alternative donor courses (double umbilical cord blood transplant (dUCBT) and haplo-identical

thiotepa
intrathecal chemotherapy
myelodysplastic syndromes
blast cells
melphalan
  • 12 views
  • 28 Jan, 2021
  • 1 location
Donor Stem Cell Transplant With Treosulfan Fludarabine and Thiotepa in Treating Patients With Non-malignant Disorders

This phase II trial studies how well donor stem cell transplant, treosulfan, fludarabine, and thiotepa work in treating patients with non-cancerous disorders. Giving chemotherapy before a donor

primary cancer
bone marrow procedure
  • 0 views
  • 29 Apr, 2021
  • 2 locations
Administration of High Dose Thiotepa and Melphalan With Autologous Hematopoietic Stem Cell Transplant in Children and Adolescents With Solid Tumors

recur. We propose a regimen of high dose thiotepa and melphalan followed by rescue of the patient's previously stored hematopoietic (blood manufacturing) system with blood stem cells. The aim

melphalan
solid tumour
solid neoplasm
thiotepa
high dose chemotherapy
  • 4 views
  • 07 Nov, 2020
  • 1 location
Freiburg ZNS-NHL Study

The purpose of this study is to determine whether combined chemotherapy [rituximab plus high dosage methotrexate (max. 2 cycles) followed by arabinoside/thiotepa (max. 2 cycles) followed

  • 2 views
  • 07 Nov, 2020
  • 1 location