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Found 10 clinical trials
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Ileal Crohn's Disease and Post-operative Outcome: Prospective Cohort Study of the REMIND Group

-operative recurrence : Thiopurines, 6-mercaptopurine (positive for clinical and endoscopic postoperative recurrence prevention), Anti-tumour necrosis factor therapy (anti-TNF), the most effective therapy

bowel resection
tumour necrosis
tumor necrosis factor
thiopurines
luminal
  • 9 views
  • 13 Nov, 2021
  • 17 locations
None
Control Crohn Safe Trial

treatment with subsequent introduction of corticosteroids, thiopurines maintenance and TNF-blockers if a previous category fails is standard care. Combination treatment with thiopurines and a TNF-blocker is

chronic disease
MRI
adalimumab
endoscopy
monoclonal antibodies
  • 0 views
  • 30 May, 2021
  • 5 locations
None
A Study to Evaluate Efficacy of Early Versus Late Use of Vedolizumab in Crohn's Disease: the LOVE-CD Study

corticosteroids and/or thiopurines and 174 patients with 'late CD' defined as active disease despite treatment with immunosuppressives and anti-TNF. Patients with intolerance to IS and anti-TNF will also be

immunosuppressive agents
vedolizumab
endoscopy
tumor necrosis factor
thiopurines
  • 0 views
  • 25 Jan, 2021
  • 26 locations
None
Combination of Diet and 5ASA ( 5-aminosalicylic Acid) for Ulcerative Colitis

Combination Therapy with Drug and Diet for Induction of Remission in Mild to Moderate Active Pediatric Ulcerative colitis: A Single Blinded, International Randomized Controlled Trial

  • 0 views
  • 28 Jan, 2021
  • 1 location
None
Endovenous Corticosteroid Pulses in Moderate Ulcerative Colitis

The purpose of this study is to determine the efficacy of high-dose corticosteroid pulses added to conventional oral corticosteroid course for moderate flares of ulcerative colitis.

prednisone
corticosteroids
  • 5 views
  • 26 Jan, 2021
  • 39 locations
None
DHPLC Determination of TPMT Polymorphisms.

TPMT is a key enzyme in the metabolism of thiopurines. TPMT polymorphisms have been described and are associated with a decrease activity of such enzyme. Therefore, a higher risk of

lymphoid leukemia
  • 6 views
  • 07 Nov, 2020
  • 1 location
None
  • 0 views
  • 04 Nov, 2021
  • 141 locations
None
Biobank - Investigating the Gut Microbiota Genetics Epigenetics and Metabolites

Inflammatory bowel disease (IBD) affects 1 in 500 to 1,000 people in the West. Previously a disease predominantly of the West, there is now a marked increase in the incidence of ulcerative colitis (UC) and Crohn's disease (CD) in Asia, with an estimated prevalence of 1 in 3,000 and 1 …

ulceration
microbiota
colitis
enteropathy
crohn's disease
  • 0 views
  • 24 Jan, 2021
None
Post-Operative Crohn's Disease Outcome in Children

with thiopurines treated patients. Design: A multi-center, prospective, observational study. Patients with either thiopurines or anti-TNF prophylaxis will be enrolled 0-6 months following ileo-cecal

azathioprine
tumour necrosis
tumor necrosis factor alpha
crohn's disease
pediatric onset crohn's disease
  • 0 views
  • 04 Oct, 2021
  • 1 location
None
An EQA Scheme for TPMT Activity and Thiopurine Metabolites

Participation in EQA schemes, where available, is mandatory for the United Kingdom Accreditation Service (UKAS). No EQA scheme currently exists for TPMT and thiopurine metabolites, which is a potential shortcoming of these tests. A pilot of this project has been awarded funding by Clinical Pathology Accreditation (CPA). The purpose of …

  • 0 views
  • 21 Jan, 2021