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Found 10 clinical trials
Ertugliflozin in Acute Heart Failure

studies that form the basis of current practice with loop diuretics as well as all studies looking at add-on thiazide therapy (current guideline-recommended adjuvant). The second is to generate a

  • 0 views
  • 20 May, 2021
  • 1 location
Treatment for Calcium Phosphate Kidney Stone Disease

The investigators will examine in two studies whether citric acid or potassium citrate can reduce calcium phosphate saturation in urine of Calcium Phosphate stone formers.

  • 180 views
  • 26 Jan, 2021
  • 1 location
The Effect of Sitagliptin on Hypertension Arterial Stiffness Oxidative Stress and Inflammation

Recently a new category of antihyperglycemic therapy aiming to modulate the incretin system has emerged. These drugs induce insulin secretion without inducing hypoglycemia. The effect of the incretin modulators drugs on hypertension, arterial stiffness, inflammation and oxidative stress parameters have not been fully investigated yet.GLP-1 analogue has been suggested to …

hemoglobin a1c
hypoglycemic agents
insulin
hypertension
arterial stiffness
  • 11 views
  • 07 Nov, 2020
  • 1 location
Diuretic Comparison Project

medications are thiazide-type diuretics that have been used for more than 50 years and are considered first-line treatment for hypertension. Patients currently prescribed hydrochlorothiazide will be

hydrochlorothiazide
hypertension
myocardial infarction
chlorthalidone
thiazide
  • 1918 views
  • 21 Jun, 2021
  • 68 locations
Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate

Chlorthalidone (CTD) may produce various metabolic disturbances, including hypokalemia, activation of Renin-Angiotensin- Aldosterone (RAA) system, oxidative stress, dyslipidemia, Fibroblast growth factor 23 (FGF23) synthesis, and magnesium depletion. These factors may interact with each other to contribute to the development of insulin resistances and metabolic syndrome. Smaller studies have suggested that …

potassium
dyslipidemia
insulin
hypertension
angiotensin
  • 22 views
  • 24 Mar, 2021
  • 3 locations
DAPAgliflozin Versus Thiazide Diuretic in Patients With Heart Failure and Diuretic RESISTance

To assess the effect of dapagliflozin compared with metolazone, added to furosemide, on diuresis and decongestion in hospitalised heart failure patients with diuretic resistance, and renal impairment. The primary analysis will be in patients with HFrEF but patients with HFpEF will also be recruited in an ancillary study and included …

  • 0 views
  • 07 May, 2021
  • 2 locations
Early Metabolic Changes With Thiazide or Beta Blocker Therapy for Essential Hypertension

Can the oral glucose tolerance test detect changes after 4 weeks treatment with thiazide diuretics or beta blockers or combination of the two?

  • 0 views
  • 07 Nov, 2020
  • 1 location
Efficacy and Safety of a Single-pill Fixed Combination of Sufficient Losartan/Hydrochlorothiazide in Chinese Hypertensive Patients

angiotensin receptor blocker (ARB) combined with thiazide diuretic (DIU), which is the preferred combination for most hypertension guidelines. However, the efficacy and safety of losartan 100 mg

losartan
amlodipine
angiotensin
hydrochlorothiazide
angiotensin converting enzyme
  • 0 views
  • 26 Mar, 2021
  • 1 location
ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension

The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older persons with hypertension when combined with physical exercise.

losartan
perindopril
hydrochlorothiazide
hypertension
antihypertensive drugs
  • 164 views
  • 21 May, 2021
  • 3 locations
Exploring Diuretics Effective Management in Acute Decompensated Heart Failure EDEMA Trial

Evaluate efficacy and safety of continuous infusion of IV Frusemide compared to IV shots in acute decompensated heart failure ADHF Evaluate superiority of time-adjusted metolazone to morning frusemide IV shots compared to irrespective administration (at random times) to overcome diuretic resistance

continuous infusion
edema
iv infusion
furosemide
chronic heart failure
  • 2 views
  • 03 Feb, 2021
  • 1 location