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Found 52 clinical trials
A Phase 1 Study of Ruxolitinib Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients

This is a phase 1, multicenter, open-label study evaluating the safety and efficacy of ruxolitinib, steroids and lenalidomide among MM patients who currently show progressive disease.

aspirin
monoclonal protein
plasmacytosis
revlimid
electrophoresis
  • 36 views
  • 24 Jan, 2021
  • 10 locations
Frontline Lenalidomide for AL Amyloidosis Involving Myocardium

This phase II clinical trial aimed at influencing the improvement of major organ functions, especially the objective response rate, in Amyloid light-chain amyloidosis involving myocardium.

cardiomyopathy
hysterectomy
lenalidomide
brain natriuretic peptide
amyloidosis
  • 1 views
  • 24 Jan, 2021
  • 1 location
Ixazomib Lenalidomide and Combination for Maintenance in NDMM Patients

The purpose of this study is to evaluate the real-world efficacy and safety of ixazomib, lenalidomide, or ixazomib in combination with lenalidomide as maintenance therapy in patients with newly diagnosed multiple myeloma in China.

ixazomib
lenalidomide
maintenance therapy
  • 1 views
  • 24 Jan, 2021
  • 1 location
A Study of PVX-410 a Cancer Vaccine and Citarinostat +/- Lenalidomide for Smoldering MM

This research study is studying a targeted therapy as a possible treatment for Smoldering Multiple Myeloma. The following intervention will be involved in this study: Lenalidomide Citarinostat (CC-96241) PVX-410

hypercalcemia
anemia
cancer
skeletal survey
renal failure
  • 109 views
  • 06 Mar, 2021
  • 2 locations
VRD as Induction Followed by VR Maintenance in Patients With Newly Diagnosed High Risk Multiple Myeloma

The phase 2 study evaluated the efficacy and safety of bortezomib in combination with lenalidomide as maintenance therapy in high risk newly diagnosed multiple myeloma patients who receive lenalidomide,bortezomib, and dexamethasone Combination as induction therapy.

monoclonal antibodies
remission
neutrophil count
induction therapy
monoclonal protein
  • 0 views
  • 26 Jan, 2021
  • 1 location
Prevention of Irinotecan Induced Diarrhea by Probiotics

Diarrhea is a relatively common complication in patients with cancer. At its inception, several mechanisms participated; malabsorption on the basis of mucositis induced by chemotherapy, dysbiosis induced by broad-spectrum antibiotics and predisposition to infectious diarrhea in immunocompromised patients. Some cytostatics and their metabolites can also induce diarrhea directly due to …

diarrhea
lactic acid
antibiotics
cancer
antibiotic therapy
  • 0 views
  • 30 Apr, 2021
  • 1 location
Lenalidomide Combined With Modified DA-EPOCH and Rituximab (EPOCH-R2) in Primary Effusion Lymphoma or KSHV-associated Large Cell Lymphoma

Background Primary effusion lymphoma (PEL) is a rare disease with no standard treatment. Researchers want to see if a drug called lenalidomide along with common chemotherapy drugs may be effective in treating PEL. Objective To test a new treatment for PEL. Eligibility People ages 18 and older with PEL. Design …

rituximab
etoposide
cyclophosphamide
methotrexate
filgrastim
  • 9 views
  • 12 Sep, 2021
  • 1 location
Clinical Implication of Bone Marrow Perfusion Patterns Imaged by Dynamic MRI in Multiple Myeloma

Background: Multiple myeloma (MM) is a clonal plasma cell neoplasm characterized by proliferation of neoplastic plasma cells in bone marrow (BM). So far, it is an incurable disease and the median survival time of MM patients is only three to four years. Till now, whether the extent of angiogenesis in …

  • 8 views
  • 07 Nov, 2020
Evaluation of Drug's Risk in Pregnant Women

Medication during pregnancy can lead to the occurrence of birth defects or neonatal pathologies. Thalidomide or diethylstilbestrol (Distilbene) are prominent examples. Many drugs remain

prenatal
  • 15 views
  • 05 Sep, 2021
  • 1 location
Diagnostic of Chemotherapy Induced Neuropathy in Children

The purpose of this study is to determine the diagnostic accuracy of a newly developed tool (Electrochemical Skin Conductances (ESC) measurement) easy-to-perform, non-invasive, highly reproductible and not requiring specific training, to identify pediatric chemotherapy-induced-peripheral-neuropathies (CIPN). CIPN are a frequent (20 to 75% depending on the drug), early and potentially severe …

carboplatin
vincristine
oxaliplatin
bortezomib
taxane
  • 0 views
  • 26 Jan, 2021
  • 1 location