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Found 70 clinical trials
A Study of IMR-687 in Subjects With Beta Thalassemia

A Study to Evaluate the Safety and Tolerability of IMR-687 in Subjects with Beta Thalassemia

beta thalassemia
cell transplantation
  • 10 views
  • 10 Jun, 2021
  • 39 locations
  • 0 views
  • 28 Jan, 2021
  • 25 locations
Allograft for Sickle Cell Disease and Thalassemia

anemias. The patient cohort to be studied: Those patients with severe sickle cell disease and thalassemia who have risk factors for high mortality and morbidity related to their disease

  • 28 views
  • 18 Feb, 2021
  • 1 location
L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension

This study compares L-arginine Versus Sildenafil as treatment for pulmonary hypertension in Children with Beta Thalassemia

beta thalassemia
hypertension
arginine
sildenafil
  • 6 views
  • 22 Jan, 2021
  • 1 location
Iron Balance Study of Deferasirox Deferoxamine and the Combination of Both

Subjects with thalassemia major require regular transfusion therapy to sustain life. The iron present in the transfused blood remains in the body where it can cause a variety of organ

deferasirox
iron
desferal
iron overload
chelation therapy
  • 28 views
  • 07 Nov, 2020
  • 1 location
Interferon and Ribavirin Treatment in Patients With Hemoglobinopathies

Worldwide, several studies report that 4.4% to 85.4% of thalassemia patients were positive for anti hepatitis C antibodies. Recently, three different studies reported the efficacy and the

ribavirin
thalassemia
hepatitis b
  • 0 views
  • 07 Nov, 2020
  • 1 location
Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter Prospective Clinical Study

The only curative therapy for thalassemia major remains the replacement of the defective erythropoiesis by allogeneic hematopoietic stem cell transplantation(allo-HSCT). We conduct a prospective

ineffective erythropoiesis
tacrolimus
mycophenolate mofetil
fludarabine
thymoglobulin
  • 1 views
  • 23 Jan, 2021
  • 1 location
Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Participants Who Require Regular RBC Transfusions Due to Beta ( )-Thalassemia.

This is a Phase 2a study to evaluate the safety and pharmacokinetics (PK) of luspatercept in pediatric participants who require regular red blood cell transfusions due to -thalassemia.

hemoglobin e
ace-536
progesterone
luspatercept
blood transfusion
  • 4 views
  • 18 Jun, 2021
  • 8 locations
Safety Tolerability Pharmacokinetics (PK) Pharmacodynamics (PD) and Preliminary Efficacy of VIT-2763 in -thalassaemia

non-transfusion-dependent Beta-thalassemia (NTDT).

blood transfusion
thalassemia intermedia
  • 17 views
  • 14 Jun, 2021
  • 16 locations
A Safety and Efficacy Study Evaluating CTX001 in Subjects With Transfusion-Dependent -Thalassemia

This is a single-arm, open-label, multi-site, single-dose Phase 1/2 study in subjects with transfusion-dependent -thalassemia (TDT). The study will evaluate the safety and efficacy of autologous

hemoglobin e
beta thalassemia
stem cell transplantation
ctx001
blood transfusion
  • 74 views
  • 22 Feb, 2021
  • 12 locations