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Found 80 clinical trials
The Management of Traumatic Hemothoraces (HemoTxRCT)

Chest injuries are common in patients with polytrauma and are responsible for approximate 25% of all trauma-related mortalities. Traumatic injuries to the thorax often result in the accumulation of blood within the chest (i.e. a hemothorax (HTX)). The management of HTX remains a clinical dilemma when the volume of blood …

conservative management
  • 03 Mar, 2022
  • 2 locations
PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma (PRiME)

The primary goal of this prospective clinical trial is to evaluate the safety of PEP-CMV in patients with recurrent medulloblastoma and malignant glioma. Patients with histologically-proven medulloblastoma or malignant glioma who had received prior therapy for their initial diagnosis and subsequently had tumor recurrence/progression may be enrolled any time after …

neutrophil count
initial diagnosis
recurrent tumor
  • 19 Jun, 2022
  • 1 location
Teletherapy in Children Who Are Deaf and Hard of Hearing

This study seeks to determine the effectiveness of speech/language teletherapy to address disparities in speech and language outcomes in children who are deaf or hard-of-hearing (D/HH). The investigators will enroll D/HH children aged 0-27 months. 140 children who are publicly insured will be randomized to receive usual clinical care or …

cochlear implant
hard of hearing
conductive hearing loss
  • 07 Oct, 2021
  • 3 locations

The PERFORM-TAVR trial (Protein and Exercise to Reverse Frailty in OldeR Men and women undergoing Transcatheter Aortic Valve Replacement) is a multicenter randomized clinical trial with a parallel-group design. The investigators will screen consecutive patients 70 years of age before TAVR and enrol those that have evidence of physical frailty …

nutritional supplement
aortic valve replacement
  • 12 Feb, 2022
  • 1 location
Neo-adjuvant SABR for IVC Tumor Thrombus in Newly Diagnosed RCC

To evaluate the safety and feasibility of pre-operative SABR of RCC IVC tumor thrombus. To evaluate the effect of pre-operative SABR in RCC IVC tumor thrombus on relapse free survival at one year.

tubal ligation
kidney tumor
kidney cancer
  • 29 Jul, 2022
  • 1 location
A Personalized Neoantigen Cancer Vaccine in Treatment Na ve Asymptomatic Patients With IGHV Unmutated CLL.

This research study is studying a novel type of CLL vaccine as a possible treatment for chronic lymphocytic leukemia (CLL) The names of the study interventions involved in this study are: Personalized NeoAntigen Vaccine Poly-ICLC Cyclophosphamide Pembrolizumab

  • 28 Sep, 2021
  • 1 location
Screening of Dysphagia Via Ultrasonography in Patients With Stroke

Oropharyngeal dysphagia is commonly seen in patients with stroke. Clinical assessment may be used to evaluate dysphagia in patients with stroke however reliability of this method is controversial and videofluoroscopic study is still considered as gold standard. However, exposure to radiation, necessity for a experienced practitioner, an expensive device, and …

Accepts healthy volunteers
  • 23 Mar, 2022
  • 1 location
Immune Function and Response to Vaccination After Cancer Therapy in Pediatric Patients

Pediatric cancer survivors have increased infection-related morbidity and mortality. This study will evaluate immune dysfunction following cancer directed systemic therapy completion, with attention to clinical relevance and infection rate in this population compared to healthy siblings, when applicable. The investigators will also restart vaccinations at earlier time points than previously …

  • 27 May, 2022
  • 1 location
Safety and Effect of Different Doses of TENDU Vaccine, a Therapeutic Peptide Conjugate Vaccine, in Patients With Relapse After Primary Radical Prostatectomy

This is a phase I, dose selection study of safety and effect of different doses of TENDU vaccine, a therapeutic peptide conjugate vaccine, in patients with relapse after primary radical prostatectomy.

  • 20 Sep, 2022
  • 1 location
Youth Empowerment Solutions: Engaging Youth for Anti Racism and Cultural Equity (YES-ERACE)

The purpose of this study is to evaluate the efficacy of YES-ERACE (Youth Empowerment Solutions for Engaging Youth for Anti-Racism and Cultural Equity) compared to regular after school programming in increasing youth empowerment, promoting anti-racist behaviors, and decreasing youth violence. Through the evidence-based YES (Youth Empowerment Solutions) program, youth design …

Accepts healthy volunteers
  • 05 May, 2022
  • 1 location