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Found 310 clinical trials
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A Study of the Efficacy and Safety of MK-5475 in Participants With Pulmonary Arterial Hypertension (INSIGNIA-PAH: Phase 2/3 Study of an Inhaled sGC Stimulator in PAH) (MK-5475-007)

This is a two-part (Phase 2/Phase 3) study of MK-5475, an inhaled soluble guanylate cyclase stimulator, in participants with pulmonary arterial hypertension (PAH). The first part (Phase 2) will assess three different doses of MK-5475 compared to placebo; the treatment dose with the best efficacy and safety profile will be …

heart disease
left ventricular end-diastolic pressure
right heart catheterization
pulmonary arterial hypertension
body mass index
  • 6 views
  • 23 Nov, 2021
  • 39 locations
None
A Study of Selexipag in Participants Who Participated in a Previous Selexipag Study

The purpose of this study is to assess the long-term safety of selexipag while providing continued selexipag treatment for participants who were previously enrolled in an Actelion-sponsored study with selexipag and who derived benefit from selexipag in indications for which a positive benefit-risk has been established.

  • 0 views
  • 29 Nov, 2021
  • 15 locations
None
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension

The purpose of this study is to evaluate whether the addition of selexipag to standard of care treatment delays disease progression in children with Pulmonary Arterial Hypertension (PAH) in comparison to placebo.

heart disease
endothelin receptor antagonist
primary pulmonary hypertension
right heart catheterization
pulmonary arterial hypertension
  • 201 views
  • 30 Nov, 2021
  • 159 locations
None
A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO) Group 1 PAH.

diuretics
hypertension
angiotensin
right heart catheterization
arginine
  • 5504 views
  • 21 Nov, 2021
  • 310 locations
None
A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH

Study ROR-PH-302, ADVANCE CAPACITY, is designed to evaluate the effects of ralinepag therapy on exercise capacity as assessed by change in peak oxygen consumption (VO2) derived from cardiopulmonary exercise testing (CPET) after 28 weeks of treatment

exercise stress test
cardiopulmonary exercise testing
ralinepag
stress test
endothelin receptor antagonist
  • 0 views
  • 24 Nov, 2021
  • 34 locations
None
A Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer

This is a randomized, open-label, three-arm, phase 3 study in men with biochemically recurrent prostate cancer and PSA doubling time 9 months at the time of study entry.

metastasis
choline
serum testosterone
luteinizing hormone-releasing hormone agonist
prostatectomy
  • 496 views
  • 23 Jan, 2021
  • 68 locations
None
TAVT-45 (Abiraterone Acetate) Granules in Patients With Prostate Cancer

The purpose of this study is to investigate the safety and efficacy of a new formulation of an existing drug product called TAVT-45 in patients with metastatic prostate cancer.

  • 3 views
  • 05 Nov, 2021
  • 30 locations
None
Letrozole in Stimulated IVF Cycles

In-vitro fertilization (IVF) is the treatment of choice for couples with prolonged infertility. The treatment usually involves hormonal stimulation of the ovaries by follicle stimulating hormone (FSH), followed by surgical removal of eggs which are then mixed with sperm in the laboratory to create embryos. The success rates of IVF …

ovulation induction
estradiol
cancer
in vitro fertilization
letrozole
  • 129 views
  • 06 May, 2021
  • 1 location
None
A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer

The purpose of this study is to determine the relative bioavailability (rBA; Period 1) and bioequivalence (BE; Period 2 and 3) of various strengths and formulations of niraparib and abiraterone acetate (AA) at steady state under modified fasted conditions in participants with metastatic castration-resistant prostate cancer (mCRPC).

  • 1 views
  • 12 Nov, 2021
  • 22 locations
None
Antiandrogen Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With Prostate Cancer That Has Been Removed by Surgery

This randomized phase II/III trial studies docetaxel, antiandrogen therapy, and radiation therapy to see how well it works compared with antiandrogen therapy and radiation therapy alone in treating patients with prostate cancer that has been removed by surgery. Androgen can cause the growth of prostate cells. Antihormone therapy may lessen …

  • 1468 views
  • 14 Nov, 2021
  • 341 locations