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Found 305 clinical trials
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Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer The ERADICATE Study

This phase III trial compares the effect of adding darolutamide to ADT versus ADT alone after surgery for the treatment of high-risk prostate cancer. ADT reduces testosterone levels in the blood

  • 0 views
  • 16 Mar, 2021
  • 7 locations
None
Examination of Idiopathic Hypogonadotropic Hypogonadism (IHH)and Kallmann Syndrome (KS)

, to secrete the reproductive hormones that influence sex hormone (testosterone, estrogen) levels and gamete (sperm, egg cell) production. This study involves a detailed evaluation and 24-48

testosterone level
serum testosterone
secondary hypogonadism
kallmann syndrome
estrogen
  • 85 views
  • 22 Aug, 2021
  • 1 location
None
Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for …

  • 255 views
  • 13 Jun, 2021
  • 299 locations
None
Comparative Health Research Outcomes of NOvel Surgery in Prostate Cancer

, whilst CHRONOS-B will compare focal therapy alone to focal therapy with various therapies targeting the testosterone pathway that can shrink the cancer before it is treated. The investigators think this

androgens
finasteride
gonadorelin
testosterone
multiparametric magnetic resonance imaging
  • 2 views
  • 25 Apr, 2021
  • 10 locations
None
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy

to suppress testosterone as effectively as standard ADT and avoid some of the side-effects. It may also help to avoid the adverse metabolic effects and fatigue and therefore improve overall quality

docetaxel
adenocarcinoma of prostate
prostate cancer metastatic
androgen suppression
metformin
  • 3777 views
  • 26 Jan, 2021
  • 120 locations
None
A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension.

To provide riociguat therapy to eligible patients with PAH originating from Bayer-sponsored trials with BAY63-2521/ Riociguat / Adempas who are currently or recently treated in these trials until lack of patient benefit as assessed by investigator, or commercial availability and reimbursement.

pulmonary arterial hypertension
riociguat
adempas
  • 0 views
  • 08 Oct, 2021
  • 13 locations
None
A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)

The primary objective of this study is to demonstrate the efficacy of inhaled treprostinil compared to placebo in improving exercise ability as measured by change from baseline in 6-Minute Walk Distance (6MWD) following 12 weeks of active treatment in participants with PH-COPD.

vasodilator
treprostinil
diuretics
right heart catheterization
left ventricular end-diastolic pressure
  • 2043 views
  • 07 Oct, 2021
  • 68 locations
None
This Study Tests the Safety of Inhaled BAY1237592 How the Drug is Tolerated and How it Effects Patients With High Blood Pressure in the Arteries of the Lungs in the Two Different Disease Groups Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

In this trial the effects of the inhaled drug BAY1237592 will be studied in patients with high blood pressure affecting the blood vessels in the lungs due to Pulmonary Arterial Hypertension (PAH) and due to Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Pulmonary hypertension is characterized by the elevation of pressure in …

chronic thromboembolic pulmonary hypertension
iloprost
nitric oxide
prostaglandin
right heart catheterization
  • 70 views
  • 10 Oct, 2021
  • 58 locations
None
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension

The purpose of this study is to evaluate whether the addition of selexipag to standard of care treatment delays disease progression in children with Pulmonary Arterial Hypertension (PAH) in comparison to placebo.

heart disease
endothelin receptor antagonist
primary pulmonary hypertension
right heart catheterization
pulmonary arterial hypertension
  • 201 views
  • 09 Oct, 2021
  • 154 locations
None
Physiological-based Cord Clamping in Congenital Diaphragmatic Hernia

Pulmonary hypertension is a major determinant of postnatal survival in infants with a congenital diaphragmatic hernia (CDH). The current care during the perinatal stabilisation period in infants born with this rare birth defect might contribute to the development of pulmonary hypertension after birth - in particular umbilical cord clamping before …

hypertension
diaphragmatic hernia
resuscitation
congenital diaphragmatic hernia
umbilical cord clamping
  • 0 views
  • 12 Aug, 2021
  • 5 locations