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Found 247 clinical trials
Novel Combination Therapy for Osteoporosis in Men (Osteo-Men)

Osteoporotic fractures are a key health problem in older men. Although there are drugs approved to treat osteoporosis in men [bisphosphonates, denosumab, and teriparatide (TPTD) or PTH(1-34)], there is a lack of knowledge on how to use them effectively. TPTD is a potent bone anabolic drug, meaning that it builds …

  • 39 views
  • 26 Feb, 2022
  • 1 location
Testosterone TRANSdermal Gel for Poor Ovarian Responders Trial

. The TTRANSPORT study will include 400 women with poor ovarian response randomized to receive pre-treatment with transdermal testosterone gel or placebo in order to provide conclusive evidence

antral
triptorelin
testosterone
follicle stimulating hormone
antral follicle count
  • 96 views
  • 10 Oct, 2021
  • 11 locations
Study of Daily Application of Nestorone® (NES) and Testosterone (T) Combination Gel for Male Contraception

The long term objective is to develop a gel to be used as a male contraceptive.

testosterone
male contraception
nestorone
Accepts healthy volunteers
depo-provera
  • 1341 views
  • 24 Mar, 2022
  • 13 locations
A Study of the Effect of Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism

Testosterone is the principal androgen produced by the male testes. Hypogonadism is the result of inadequate production of testosterone by the Leydig cells of the testes and is reflected by

testosterone
testosterone gel
diastolic blood pressure
secondary hypogonadism
screening procedure
  • 140 views
  • 28 May, 2022
  • 24 locations
A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy (CASPAR)

cancer that has spread to other places in the body (metastatic) and has become resistant to testosterone-deprivation therapy (castration-resistant). Enzalutamide helps fight prostate cancer by blocking

  • 4 views
  • 09 Aug, 2022
  • 249 locations
Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The ERADICATE Study

This phase III trial compares the effect of adding darolutamide to ADT versus ADT alone after surgery for the treatment of high-risk prostate cancer. ADT reduces testosterone levels in the blood

  • 32 views
  • 11 Aug, 2022
  • 65 locations
Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score

tumors. Androgen deprivation therapy blocks the production or interferes with the action of male sex hormones such as testosterone, which plays a role in prostate cancer development. Giving radiation

  • 7 views
  • 11 May, 2022
  • 56 locations
Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for …

  • 393 views
  • 14 Feb, 2022
  • 287 locations
Comparative Health Research Outcomes of NOvel Surgery in Prostate Cancer (IP4-CHRONOS)

, whilst CHRONOS-B will compare focal therapy alone to focal therapy with various therapies targeting the testosterone pathway that can shrink the cancer before it is treated. The investigators think this

testosterone
antiandrogens
brachytherapy
gonadorelin
bicalutamide
  • 13 views
  • 27 Feb, 2022
  • 8 locations
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE)

to suppress testosterone as effectively as standard ADT and avoid some of the side-effects. It may also help to avoid the adverse metabolic effects and fatigue and therefore improve overall quality

metastatic prostate cancer
testosterone
antiandrogen therapy
docetaxel
prostate cancer metastatic
  • 3825 views
  • 04 May, 2022
  • 115 locations