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Found 239 clinical trials
Stereotactic Body Radiotherapy With or Without Darolutamide for OligoRecurrent Prostate Cancer

The current trial will test the combination of darolutamide with SBRT, in oligometastatic recurrent hormone sensitive prostate cancer. We hypothesize that the addition of short-term darolutamide improves metastasis-free survival when added to SBRT without a detrimental impact on the QoL. Considering the large reluctance of both patients and physicians to …

cancer
radical prostatectomy
adenocarcinoma
  • 0 views
  • 22 Jul, 2021
  • 7 locations
Autologous Ovarian Tissue Transplantation

Chemotherapy and radiation for cancer and other conditions can cause infertility. Several centers around the world are cryopreserving ovarian tissue from these patients though an experimental protocol, including the Fertility Preservation Program in Pittsburgh (protocol PRO08050491). The objective of this study is to study the efficacy and safety of autologous …

cancer
ovarian failure
fertility preservation
infertility
  • 450 views
  • 04 Jun, 2022
  • 1 location
Investigating the Endocrinological and Physiological Responses to Short-term Reduced Carbohydrate Availability in Males.

Using a randomised crossover design, nine weight-stable men, aged 18 - 40 years old, will be recruited via convenience sampling from the staff and student body of LJMU and local area. Participants will be asked to follow two 4-day (~96 hours) periods of tightly controlled exercise energy expenditure (15 kcal/kg …

Accepts healthy volunteers
  • 0 views
  • 10 Oct, 2022
  • 1 location
Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?

The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone normalizes sleep-wake luteinizing hormone (LH) pulse frequency (primary endpoint) and overall LH and follicle-stimulating hormone secretion (secondary endpoints).

  • 8 views
  • 04 Oct, 2022
  • 1 location
Myo-Inositol for Infertility in PCOS

This will be a prospective, double-blind randomized clinical trial of letrozole and placebo versus letrozole and inositols for up to 5 treatment cycles of ovulation induction or until pregnancy is achieved. All participants and members of the research team will be blinded to the treatment arms. Placebo and inositol supplement …

inositol
anovulatory
anovulation
infertility
ovulation induction
  • 57 views
  • 30 May, 2022
  • 1 location
Letrozole /GnRH Antagonist Protocol in Women Over 40 Years Undergoing ICSI Cycle

The aim of this study To compare the clinical and laboratory outcomes of two ovarian stimulation protocols (standard GnRH antagonist protocol and aromatase inhibitor/ antagonist protocol) in women (40-44) years undergoing ICSI cycle.

  • 0 views
  • 29 Dec, 2021
  • 1 location
Phase 2 Study of High Dose-Rate Brachytherapy and Stereotactic Body Radiotherapy for Intermediate and High Risk Localized Prostate Adenocarcinoma (HYDRA) (HYDRA)

This phase II trial investigates the effect of high dose-rate brachytherapy and stereotactic body radiotherapy in treating patients with prostate adenocarcinoma. Brachytherapy, also known as internal radiation therapy, uses radioactive material placed directly into or near a tumor to kill tumor cells. Stereotactic body radiation therapy uses special equipment to …

  • 0 views
  • 21 Oct, 2022
  • 1 location
2 Ablative RadioTherapy Treatments for Prostate Cancer (EARTH)

Favorable-risk prostate cancer represent a large proportion of patients diagnosed with prostate cancer and image guided radiation therapy (IGRT) is commonly used to treat these patients using protracted courses of up to 39 treatments over 8 weeks. Stereotactic ablative body radiotherapy (SABR) protocols hold the promise of more convenience, less …

  • 0 views
  • 05 Jul, 2022
  • 1 location
Nivolumab + Docetaxel + ADT in mHSPC Patients With DDRD or Inflamed Tumors

This research study is studying a combination of hormonal therapy, chemotherapy, and immunotherapy as a possible treatment for metastatic hormone-sensitive prostate cancer. The names of the study drugs involved in this study are: Androgen deprivation therapy (ADT) with a drug of your physician's choice. This may include leuprolide (Lupron), goserelin …

cancer
leuprolide
antiandrogen therapy
androgens
metastatic prostate cancer
  • 0 views
  • 20 Apr, 2022
  • 4 locations
Multimodality Intervention for Function and Metabolism in SCI

The proposed phase 2 trial a randomized, placebo-controlled, parallel group trial in persons with cervical or thoracic SCI, AIS grade A, B, C, or D, 6 months or later after injury. The trial will test the hypothesis that a Home-Based Multimodality Functional Recovery and Metabolic Health Enhancement Program that addresses …

Accepts healthy volunteers
spinal cord
electrical stimulation
spinal cord disorder
  • 0 views
  • 04 Oct, 2022
  • 1 location