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Found 81 clinical trials
Treatment of Newly Diagnosed High Risk Acute Lymphoblastic Leukemia in Children

Treatment of pediatric acute lymphoblastic leukemia (ALL) has advanced and the overall survival exceeds 80% nowadays. However the overall survival of high risk ALL remains 75-90%, thus recent studies focus on treatment intensification according to the risk group. According to the previous reports, we designed a multicenter prospective trial for …

white blood cell count
childhood all
lymphoid leukemia
b-cell acute lymphoblastic leukemia
  • 21 Jan, 2021
Study of Dose Escalation of Abiraterone Actetate in Prostate Cancer

The purpose of this study is to test whether a dose escalation up to 2000 mg per day of abiraterone acetate is feasible and lead to disease stabilization in castration-resistant metastatic prostate cancer patients who experience disease progression within the first 6 months of abiraterone actetate at standard dose (1000 …

prostate cancer metastatic
adenocarcinoma of prostate
  • 25 Jan, 2021
  • 1 location
Treatment of Radiation and Cisplatin Induced Toxicities With Tempol

A 10 week trial to assess the ability of Tempol to prevent and/or reduce toxicities associated with cisplatin and radiation treatment in head and neck cancer patients. Over the course of the 10 week trial, mucositis, nephrotoxicity, and ototoxicity will be monitored and assessed.

neutrophil count
squamous cell carcinoma
a 10
squamous cell carcinoma of the head and neck
neck cancer
  • 23 Jan, 2021
  • 4 locations
Prospective Controlled Randomized Multicentric Study on the Management of the Vesical Catheter in Colon Surgery.

INTRODUCTION: Recommendations for peroperative bladder catheterization remain a controversial issue since it is a procedure that is not without complications. Most of the current suggestions derive from open surgery data that have been extrapolated to Enhanced Recovery After Surgery (ERAS) or Fast-Track programs ranging between 24-48 hours. The objective of …

colon operation
enhanced recovery after surgery
open surgery
  • 24 Jan, 2021
  • 1 location
Dose Escalation Study of Immunomodulatory Nanoparticles

PRECIOUS-01 is an immunomodulating agent composed of the invariant natural killer T cell (iNKT) activator threitolceramide-6 (ThrCer6, IMM60) and the New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1) cancer-testis antigen peptides encapsulated in a poly(lactic-co-glycolic acid) (PLGA) nanoparticle. PRECIOUS-01 is being developed for the treatment of patients with NY-ESO-1-positive cancers.

  • 18 Feb, 2021
  • 1 location
Regulation of Stem Spermatogonia in the Mature Testis

Investigative trial to evaluate the role of a glial cell lined derived neurotrophic factor (GDNF) in regulation of spermatogonial renewal and testicular function. Goal of the trial is to provide

neurotrophic factor
  • 23 Jan, 2021
  • 1 location
Impact of Exposure to Environmental Pollutants on Birth Outcomes in an Israeli Cohort

Objectives and hypothesis The scale and diversity of chemicals in worldwide use today is vast. Many of these chemicals are released into the environment where they are found in air, water, soil, house dust, and in the food supply, resulting in exposure to humans. Characterizing the extent of exposure and …

  • 21 Jan, 2021
  • 2 locations
Impact of Immunotherapy on the Sperm Count of Patients With Cancer

Cancer is a public health problem. In recent years, oncology has been revolutionized with the advent of new treatments for different tumor models, mainly immunotherapy directed against cell cycle control points. Numerous inhibitory pathways are incorporated into the immune system to maintain tolerance and homeostasis, and these are collectively known …

  • 25 Jan, 2021
  • 1 location
Swiss Austrian German Testicular Cancer Cohort Study - SAG TCCS

The majority of testicular cancer patients can be cured with cisplatin-based chemotherapy. Mortality has been reduced even more within the last 15 years due to the stringent application of

cardiovascular disease
renal function tests
  • 23 Jan, 2021
  • 1 location
Testicular Growth During Puberty in Boys With and Without a Left-sided Varicocele

testicular growth could predict the outcome of boys with a varicocele. During this study, testicular growth in boys with and without a left-sided varicocele will be examined in different schools using

  • 23 Jan, 2021