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Found 16 clinical trials
Melatonin in Patients With Multiple Sclerosis (MS).

To date, there are no published data on the role of melatonin supplementation or the appropriate dose for patients with multiple sclerosis. Because of the potential benefits of melatonin, this pilot study will be an exploratory investigation to evaluate the effect of supplementing melatonin in subjects with multiple sclerosis who …

fingolimod
teriflunomide
fumarate
  • 8 views
  • 23 Jan, 2021
  • 1 location
Leflunomide for the Treatment of Severe COVID-19 in Patients With a Concurrent Malignancy

This phase I/II trial investigates the best dose and side effects of leflunomide and how well it works in treating patients with COVID-19 and a past or present cancer. Leflunomide has been used since the 1990s as a treatment for rheumatoid arthritis. Experiments done with human cells that were given …

  • 0 views
  • 04 Feb, 2021
  • 1 location
Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease

This phase I trial studies the side effects of leflunomide in treating patients with steroid dependent chronic graft versus host disease (cGVHD). cGVHD is a common complication of bone marrow transplant. GVHD occurs when immune cells transplanted from a donor (the graft) recognize the transplant recipient (the host) as foreign, …

bone marrow transplant
platelet transfusions
tacrolimus
serum pregnancy test
corticosteroids
  • 0 views
  • 25 Jan, 2021
  • 1 location
Hematopoietic Stem Cell Therapy for Inflammatory Multiple Sclerosis Failing Alternate Approved Therapy

The purpose of this study is to assess the efficacy of autologous PBSCT versus FDA approved standard of care (i.e. interferon, glatiramer acetate, mitoxantrone, natalizumab, fingolimod, or tecfidera) for inflammatory MS failing alternate approved therapy. Disease progression, defined as a 1-point increase in the Expanded Disability Status scale (EDSS) on …

mitoxantrone
glatiramer acetate
interferon
gilenya
MRI
  • 120 views
  • 08 Nov, 2020
  • 1 location
An Observational Study on Teriflunomide-exposed Pregnancies

Primary Objective: To evaluate any potential increase in the risk of major birth defects, in the first year of life, in teriflunomide-exposed pregnancies. Secondary Objective:

teriflunomide
  • 8 views
  • 26 Jan, 2021
  • 2 locations
Effect of Teriflunomide Treatment on Microglial Activation in an MS Patient Cohort at Risk of Progression

To evaluate the effect of teriflunomide treatment on microglial activation in late stage multiple sclerosis.

brain mri
teriflunomide
  • 0 views
  • 25 Jan, 2021
  • 1 location