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Found 26 clinical trials
Switching From TDF-based Antiretroviral Therapy Regimens to B/F/TAF in Virally Suppressed Adults With HIV-1 Infection

To evaluate the safety and efficacy of bictegravir/emtricitabine/tenofovir alafenamide versus tenofovir disoproxil fumarate-based antiretroviral regimens in HIV-infected individuals with

  • 0 views
  • 12 Mar, 2022
  • 2 locations
Efficacy and Safety of TAF in Patients With Suboptimal Response to Other Nucleos(t)Ides

Both tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) are potent antiviral agents for hepatitis B virus (HBV) and recommended by the American Association for the Study of

chronic hepatitis
telbivudine
lamivudine
tenofovir alafenamide 25 mg
antiviral therapy
  • 0 views
  • 21 Feb, 2022
  • 10 locations
Tenofovir Alafenamide Switching Therapy in Kidney or Liver Transplant Recipients With Chronic HBV Infection

tenofovir alafenamide (TAF) has been approved to be highly effective and safe in patients with chronic hepatitis B (CHB), therefore TAF may be a good option in kidney or liver transplant patients with chronic HBV infection. The aim of this prospective cohort study is to assess the safety, efficacy, and …

  • 0 views
  • 29 Jun, 2022
  • 1 location
A RCT of TNF and ENT in the Treatment of Long-term Prognosis With Hepatitis B-related HCC After Curative Resection

receive Tenofovir disoproxil fumarate, while the other half will receive Entecavir.

  • 0 views
  • 24 Jan, 2021
  • 1 location
Evaluating the Pharmacokinetics, Feasibility, Acceptability, and Safety of Oral Pre-Exposure Prophylaxis for HIV Prevention During Pregnancy and Postpartum

The purpose of this study is to evaluate the pharmacokinetics, feasibility, acceptability, and safety of a fixed-dose combination of emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) as

acute hiv infection
Accepts healthy volunteers
HIV Vaccine
emtricitabine
tenofovir
  • 142 views
  • 07 Oct, 2022
  • 6 locations
Simplifying Treatment and Monitoring for HIV (STREAM HIV)

POC viral load (VL) monitoring in improving ART adherence, maintaining durable VL suppression, and improving retention in care among HIV-positive individuals initiating first-line tenofovir disoproxil

  • 0 views
  • 09 Jun, 2022
  • 1 location
Change of Renal Function and Bone Mineral Density in CHB Patients Switch From TDF to TAF vs. Maintaining TDF

In Chronic hepatitis B (CHB) patients receiving long-term sequential Neucleos(t)ides(NAs), majority of these CHB patients experienced drug resistance and switched to Tenofovir disoproxil fumaratate(TDF). However, some of patients on long term TDF experienced impairment of renal function and bone mineral density. After Tenofovir alafenamide(TAF) was in clinical practice, these group …

hepatitis
chronic hepatitis
antiviral drugs
fumarate
tenofovir
  • 45 views
  • 08 Sep, 2021
  • 1 location
Pradefovir Treatment for the Patients With Chronic Hepatitis B Virus Infections: a Phase3 Study

This is a phase three study to evaluate the safety and efficacy of Pradefovir treatment in chronic hepatitis B patients. Subject will be randomized to Pradefovir group and TDF group at a ratio of 2:1. Treatment duration will be 96w in randomization and followed by 48w in open. The interim …

fumarate
hepatitis
tenofovir
  • 13 views
  • 25 Jan, 2021
  • 1 location
E-Health for Zero Infections - Facilitating Access to and Use of HIV Pre-Exposure Prophylaxis (PrEP) in The Netherlands

Offering PrEP care online and reducing the frequency of monitoring may increase access to HIV PrEP. The objective of this study is to assess the non-inferiority of an internet-based HIV PrEP-service and reduced frequency of monitoring visits in comparison to standard-of-care at the Public Health Service in 4 regions in …

pre-exposure prophylaxis (prep)
Accepts healthy volunteers
HIV Vaccine
  • 0 views
  • 01 Nov, 2021
  • 4 locations
Tenofovir Disoproxil Fumarate in Combination of Hepatitis B Vaccine for Preventing Hepatitis B Vertical Transmission

HBV DNA > 200,000 IU/mL is the major independent risk for mother-to-child transmission (MTCT). A recent randomized controlled trial has shown that Tenofovir Disoproxil Fumarate (TDF) use during the

vaccination
mother-to-child transmission
tenofovir
hepatitis
hepatitis b immune globulin
  • 81 views
  • 02 Mar, 2022
  • 7 locations