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Found 193 clinical trials
Trial in Low Grade Glioma Patients: Wait or Treat

post-operative treatment. It will establish whether early adjuvant treatment with radiotherapy and adjuvant temozolomide in resected IDHmutated astrocytoma will improve outcome, and whether benefits of

astrocytoma
seizure
temozolomide
initial diagnosis
neutrophil count
  • 0 views
  • 16 Sep, 2021
  • 36 locations
Treatment Intensification With Temozolomide in Adults With a Glioblastoma

Due to conflicting data on the optimal moment to start TMZ chemotherapy and the impact of prolongation of the adjuvant phase with TMZ, the ANOCEF (Association des Neuro-Oncologues d'Expression Francophone) group proposes this randomized trial comparing an intensified arm (early TMZ and extended adjuvant TMZ until toxicity, progression or patient …

karnofsky performance status
temozolomide
  • 35 views
  • 29 Apr, 2021
  • 19 locations
A Study of Abemaciclib (LY2835219) in Combination With Temozolomide and Irinotecan and Abemaciclib in Combination With Temozolomide in Children and Young Adult Participants With Solid Tumors

The study's purpose is to see if the drug abemaciclib is safe and effective in combination with temozolomide and irinotecan (Part A) and abemaciclib in combination with temozolomide (Part B) in

  • 0 views
  • 12 Sep, 2021
  • 17 locations
TEMOkids Study : A Phase I Pediatric Study for KIMOZO Oral Suspension of Temozolomide

Non-randomized, international, multi-centre, open-label, single arm study to determine the pharmacokinetic (PK) parameters of a single dose of an oral suspension of temozolomide (KIMOZO) in the

  • 0 views
  • 11 Mar, 2021
  • 10 locations
Pivotal Randomized Open-label Study of Optune (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM

To test the effectiveness and safety of Optune given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM patients, compared to radiation therapy and

tumor treating fields therapy
complete resection
cancer
corticosteroids
karnofsky performance status
  • 25 views
  • 02 Sep, 2021
  • 162 locations
Veliparib Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

This phase II trial studies how well veliparib, radiation therapy, and temozolomide work in treating patients with newly diagnosed malignant glioma without H3 K27M or BRAFV600 mutations. Poly

anaplastic astrocytoma
astrocytoma, anaplastic
immunohistochemistry
glioblastoma multiforme
platelet count
  • 403 views
  • 19 Sep, 2021
  • 112 locations
Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

therapy when given with temozolomide in patients with newly diagnosed glioblastoma. Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells and shrink tumors

glioblastoma multiforme
neutrophil count
karnofsky performance status
x-rays
contrast-enhanced magnetic resonance imaging
  • 317 views
  • 08 Jul, 2021
  • 45 locations
Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients

astrocytoma has recurred/progressed after radiation and temozolomide chemotherapy.

flair
lomustine
anaplastic astrocytoma
astrocytoma, anaplastic
glioblastoma multiforme
  • 0 views
  • 25 May, 2021
  • 120 locations
2-OHOA With RT and TMZ for Adults With Glioblastoma

2-OHOA versus placebo, given with standard of care (SoC) therapy of radiation therapy plus temozolomide (TMZ), followed by an adjuvant treatment of 6 month period of TMZ and then 2-OHOA or placebo

tamoxifen
renal function test
temozolomide
malignant glioma
neutrophil count
  • 12 views
  • 25 Jul, 2021
  • 14 locations
Study on Tailored Treatment in Elderly Patients With Newly Diagnosed Primary Lymphoma of Central Nervous System

, temozolomide and rituximab as induction therapy, followed by temozolomide as maintenance treatment; the aim is to evaluate the efficacy of this combination of treatment.

whole-brain radiotherapy
lenalidomide
maintenance treatment
cancer
rituximab
  • 0 views
  • 19 Jun, 2021
  • 42 locations