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Found 195 clinical trials
Safety Study of Cetuximab Radiotherapy and Temozolomide in Primary Glioblastoma Multiforme(GERT)

GERT is a one-armed single-center phase I/II trial. In a first step, dose-escalation of TMZ from 50 mg/m2 to 75mg/m2 together with radiotherapy and cetuximab will be performed. Should safety be proven, the phase II trial will be initiated with the standard dose of 75mg/m2 of TMZ. Cetuximab will be …

temozolomide
neutrophil count
  • 60 views
  • 07 Nov, 2020
  • 1 location
AQ4N in Combination With Radiotherapy and Temozolomide in Subjects With Newly Diagnosed Glioblastoma Multiforme

Phase 1b of the study, will evaluate the safety and tolerability of AQ4N treatment at three different dose levels. Phase 2a of the study, will further evaluate the safety, tolerability, and in addition efficacy of AQ4N treatment at a tolerated dose selected from Phase 1b.

temozolomide
karnofsky performance status
  • 305 views
  • 07 Nov, 2020
  • 2 locations
A Study of Toripalimab or Combining With Temozolomide iv in the Treatment of Advanced/Metastatic Malignant Melanoma

This study evaluate toripalimab or combining with temozolomide for injection in the treatment of advanced/metastatic malignant melanoma. Participants in arm A receive toripalimab, in arm B

temozolomide
braf v600e mutation
systemic therapy
BRAF
  • 0 views
  • 24 May, 2021
  • 1 location
Efficacy and Safety Study of GX-I7 Plus Adjuvant Temozolomide Combination in Patients With Newly Diagnosed Glioblastoma

This is a phase 1/2, randomized, placebo-controlled study to evaluate safety, tolerability, anti-tumor activity and impact on absolute lymphocyte count of GX-I7 plus adjuvant temozolomide

  • 0 views
  • 23 Jan, 2021
  • 1 location
Multi Peptide Vaccination With XS15 in Addition to Standard Postoperative Radiation Therapy and Temozolomide Chemotherapy in Newly Diagnosed Glioblastoma

standard postoperative radiation therapy and temozolomide chemotherapy to assess immunogenicity, efficacy, safety of the combination of multipeptide vaccination and the immune modulator XS15 emulsified in

  • 0 views
  • 24 May, 2021
  • 1 location
Pembrolizumab for Newly Diagnosed Glioblastoma

The study explores the addition of pembrolizumab to temozolomide-based radiotherapy in patients with newly diagnosed glioblastoma.

  • 0 views
  • 27 Jan, 2021
  • 3 locations
First-line Chemotherapy With Temozolomide Alone for Non-enhancing Adult Brainstem Gliomas With a Diffuse Subtype and Showing Clinical and/or Radiological Infiltrative Pattern of Progression

-threatening clinico-radiological progression. Patients will receive temozolomide at a monthly standard dose of 150-200 mg/m2/j J1-J5, will be clinically evaluated every month and will undergo radiological

  • 0 views
  • 19 Sep, 2021
  • 0 views
  • 01 May, 2021
  • 1 location
Cabozantinib in High Grade Neuroendocrine Neoplasms

, capecitabine and temozolomide, taxanes or immunotherapy) and there is urgent need for better regimens.

  • 0 views
  • 05 Feb, 2021
  • 1 location
Potentiation of Chemotherapy in Brain Tumors by Zinc

poor. Temozolomide (TMZ) as an alkylating agent has become part of GBM management but it has contributed only marginally to prolongation of life in GBM patients. Our aim is to evaluate the therapeutic

  • 0 views
  • 25 Jan, 2021
  • 1 location