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Found 193 clinical trials
Adjuvant Dendritic Cell-immunotherapy Plus Temozolomide in Glioblastoma Patients

(m)RNA-loaded dendritic cell (DC) vaccination is added to adjuvant temozolomide maintenance treatment following (sub)total resection and temozolomide-based chemoradiation.

  • 23 views
  • 28 Jan, 2021
  • 1 location
Prolonged Adjuvant Temozolomide vs "Stop & Go" in Glioblastoma Patients

This study will test the hypothesis that prolonged adjuvant Temozolomide (TMZ) may delay relapses in patients with glioblastoma compared to the standard care consisting in observation

temozolomide
methionine
cancer
karnofsky performance status
  • 65 views
  • 07 Nov, 2020
  • 1 location
Preoperative CRT With Capecitabine Temozolomide in Patients With LARC

This is a prospective biomarker-stratified, randomised phase II study of preoperative CRT with temozolomide plus capecitabine in patients with locally advanced rectal cancer. The primary

  • 15 views
  • 27 Jan, 2021
  • 1 location
Capecitabine and Temozolomide for Treatment of Recurrent Pituitary Adenomas

This is an open label study to assess the efficacy of capecitabine (CAP) and temozolomide (TMZ) in recurrent pituitary adenomas. There will be a safety run-in of at least three patients to

  • 5 views
  • 28 Jan, 2021
  • 1 location
A Phase II Study Of Gliadel Concomitant Temozolomide And Radiation Followed By Dose Dense Therapy With Temozolomide Plus Bevacizumab For Newly Diagnosed Malignant High Grade Glioma

To determine the safety and efficacy of surgical resection with Gliadel® 3.85% wafer implantation, followed by concomitant limited field radiation therapy and temozolomide, followed by

bevacizumab
gliadel
cerebral tumor
temozolomide
MRI
  • 9 views
  • 07 Nov, 2020
  • 1 location
Apatinib Combined With Temozolomide and Etoposide Capsules in the Treatment of Recurrent Medulloblastoma in Children

This study is a prospective single-center clinical study, which aims to observe and evaluate the efficacy and safety of apatinib combined with temozolomide and oral etoposide in the treatment of

  • 0 views
  • 23 Mar, 2021
  • 1 location
5FU/LV Irinotecan Temozolomide and Bevacizumab for MGMT Silenced Microsatellite Stable Metastatic Colorectal Cancer.

active chemotherapeutic agents might overcome resistance to single drugs. Temozolomide has modest but non-negligible activity (about 10%) in chemo-refractory patients with MGMT methylated mCRC

  • 1 views
  • 01 Mar, 2021
  • 1 location
Safety Study of Cetuximab Radiotherapy and Temozolomide in Primary Glioblastoma Multiforme(GERT)

GERT is a one-armed single-center phase I/II trial. In a first step, dose-escalation of TMZ from 50 mg/m2 to 75mg/m2 together with radiotherapy and cetuximab will be performed. Should safety be proven, the phase II trial will be initiated with the standard dose of 75mg/m2 of TMZ. Cetuximab will be …

temozolomide
neutrophil count
  • 60 views
  • 07 Nov, 2020
  • 1 location
AQ4N in Combination With Radiotherapy and Temozolomide in Subjects With Newly Diagnosed Glioblastoma Multiforme

Phase 1b of the study, will evaluate the safety and tolerability of AQ4N treatment at three different dose levels. Phase 2a of the study, will further evaluate the safety, tolerability, and in addition efficacy of AQ4N treatment at a tolerated dose selected from Phase 1b.

temozolomide
karnofsky performance status
  • 305 views
  • 07 Nov, 2020
  • 2 locations
Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma

This is a Phase I study that examines the rate of dose limiting side effects in patients with malignant astrocytoma treated with combination acetazolamide (ACZ) and temozolomide (TMZ). Eligible

  • 1 views
  • 22 Jun, 2021
  • 1 location