Found 201 clinical trials
A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur after Irradiation and Adjuvant Temozolomide Chemotherapy
has recurred/progressed after radiation and temozolomide chemotherapy.
- 5 views
- 11 Jun, 2020
- 1 location
ACNS0822: A Randomized, Phase II/III Study of Vorinotat (IND#71976) and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab (IND#7921) and Local Irradiation Followed by Maintenance Bevacizumab and Temozolomide in Children with Newly Diagnosed High-Grade Gliomas
ACNS0822: A Randomized, Phase II/III Study of Vorinotat (IND#71976) and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab (IND#7921) and Local Irradiation Followed by
- 66 views
- 08 Nov, 2020
- 1 location
ACNS0821:Temozolomide With Irinotecan Versus Temozolomide, Irinotecan Plus Bevacizumab (NSC# 704865, BB-IND# 7921) for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial
ACNS0821:Temozolomide With Irinotecan Versus Temozolomide, Irinotecan Plus Bevacizumab (NSC# 704865, BB-IND# 7921) for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized
- 106 views
- 08 Nov, 2020
- 1 location
RTOG-0834: Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial
RTOG-0834: Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial
- 112 views
- 08 Nov, 2020
- 1 location
ANBL1221: A Phase II Randomized Trial of Irinotecan/Temozolomide With Temsirolimus (NSC# 683864, IND# 61010) or Chimeric 14.18 Antibody (ch14.18) (NSC# 623408, IND# 4308) in Children With Refractory, Relapsed or Progressive Neuroblastoma
ANBL1221: A Phase II Randomized Trial of Irinotecan/Temozolomide With Temsirolimus (NSC# 683864, IND# 61010) or Chimeric 14.18 Antibody (ch14.18) (NSC# 623408, IND# 4308) in Children With Refractory
- 298 views
- 08 Nov, 2020
- 1 location
N0577 (CODEL) Phase III Intergroup Study of Radiotherapy with Concomitant and Adjuvant Temozolomide versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q co-deleted Anaplastic Glioma or Low Grade Glioma
PCV (Procarbazine, CCNU, and Vincristine) or radiation with temozolomide during and after radiation, to see which is better.
- 10 views
- 24 Jun, 2021
- 1 location
OT-15-001 (STELLAR) A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After irradiation and Adjuvant Temozolomide Chemotherapy
People who were previously diagnosed with an anaplastic astrocytoma (WHO grade III astrocytoma) and now have evidence that their tumor has returned or has tarted to grow again without concern that it has progressed to a glioblastoma (WHO grade IV astrocytoma) may be eligible to participate. This study is comparing …
- 10 views
- 24 Jun, 2021
- 1 location
Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the
- 167 views
- 22 Jul, 2021
- 126 locations
Study to Assess Safety Tolerability and Clinical Activity of BGB-290 in Combination With Temozolomide (TMZ) in Participants With Locally Advanced or Metastatic Solid Tumors
The primary objective of this study is to determine the safety and tolerability of pamiparib, the maximum tolerated dose (MTD) or maximum administered dose (MAD) for pamiparib combined with TMZ, to select the recommended Phase 2 dose (RP2D) and schedule of pamiparib in combination with TMZ, and to determine the …
- 28 views
- 25 Jun, 2021
- 28 locations
Irinotecan and Temozolomide for Ewing Sarcoma
The investigators explored the activity of vincristine and irinotecan combined with temozolomide (VIT) in patients with relapsed and metastatic Ewing Sarcoma.
- 55 views
- 22 Jan, 2021
- 1 location