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Found 4 clinical trials
Temodar Plus Tyrosine Kinase Inhibitors for Progressive CNS Disease

This trial is testing two novel combinations (temozolomide plus osimertinib OR temozolomide plus lorlatinib) which have not been evaluated in clinical trials. Thus, the exact benefits of these novel combinations are unclear. However, based on the mechanism of action of temozolomide and CNS(Central Nervous System) penetration/activity in other tumor types, …

  • 16 Mar, 2021
  • 1 location
INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

>Temozolomide (temodar) Neratinib CC115

therapeutic agent
measurable disease
karnofsky performance status
neutrophil count
  • 06 Mar, 2021
  • 12 locations
Phase I Study of Olaparib and Temozolomide for Ewings Sarcoma or Rhabdoomyosarcoma

patients with Ewing's sarcoma. The investigational drug olaparib is not approved for any use outside of research studies. Temozolomide (Temodar) is approved by the FDA for the treatment of a type of

brain tumor
ewing's sarcoma
cancer chemotherapy
measurable disease
  • 27 Jan, 2021
  • 3 locations
NovoTTF-200A Together With Radiation Therapy and Temozolomide in Patients With Newly Diagnosed GBM

Study Objectives: To compare the efficacy and safety outcome of newly diagnosed GBM patients treated with NovoTTF-200A concomitant to RT and TMZ to those treated with RT and TMZ alone Study Design: Prospective, randomized, open label, standard of care control Study Hypothesis: The hypothesis of this study is that addition …

  • 22 Jan, 2021