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Found 645 clinical trials
The Swedish BioFINDER 2 Study (BioFINDER2)

of AD and other neurodegenerative diseases. With the advent of new tau-PET tracers there is now an opportunity to elucidate the role of tau pathology in the pathogenesis of AD and other tauopathies

brain imaging
dementia
mini-mental state examination
alzheimer's disease
amyloid
  • 178 views
  • 25 Feb, 2022
  • 1 location
A First-in-Human Study to Assess Single Doses of APNmAb005 in Healthy Participants

This is a Phase 1, first-in-human (FIH), double-blinded, placebo-controlled study where healthy subjects are randomly allocated to receive APNmAb005 or placebo. Approximately 5 dosing groups (cohorts) are planned with 8 subjects (randomized to 6 active: 2 placebo) per cohort. the starting dose of APNmAb005 is 5 mg/kg and the anticipated …

Accepts healthy volunteers
body mass index
  • 0 views
  • 19 Jun, 2022
  • 1 location
Validation of Blood Biomarkers for Alzheimer's Disease (ALZAN)

Alzheimer's disease (AD) has gradually become one of the major global public health issues due to its prevalence, which increases with age and life expectancy, and the economic cost of caring for patients whose cognitive decline progressively leads to loss of functional autonomy. The diagnosis of AD is based on …

beta amyloid protein
cognitive decline
amyloid
cognitive assessment
alzheimer's disease
  • 0 views
  • 25 Jul, 2022
  • 3 locations
Harmony at Home: A Pilot Telehealth Program for Rural ADRD Caregivers

There is a need for caregiver-initiated and -implemented non-pharmacological interventions directly to and for the person with dementia, including environmental assessment and modification, as first-line treatments for behavioral and psychological symptoms of dementia (BPSD) in persons living with dementia (PLWD). Delivered via telehealth, Harmony at HOME (H@H) aims to train …

dementia
cognitive assessment
BPSD
Accepts healthy volunteers
psychological symptoms
  • 0 views
  • 23 Apr, 2022
  • 1 location
Study to Assess the Efficacy of XPro™ in Patients With Mild Alzheimer's Disease With Biomarkers of Inflammation (MINDFuL)

The purpose of this study is to measure cognitive and biological biomarkers in subcutaneously administered XPro™ or placebo in patients with mild ADi.

amyloid
dementia
cognitive assessment
mild dementia
alzheimer's disease
  • 0 views
  • 19 Apr, 2022
  • 1 location
An Open-Label Extension of XPro1595 in Patients With Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI) Due to AD That Have Completed a Phase 2 Study With XPro1595

The goal of this Phase 2 Open-Label Extension (OLE) is to evaluate long-term safety, tolerability, and efficacy of XPro1595 on measures of cognition, function and brain quality in individuals with mild Alzheimer's Disease or MCI with biomarkers of inflammation.

cognitive assessment
alzheimer's disease
  • 0 views
  • 14 Sep, 2022
  • 1 location
Tau PET Imaging With 18F-T807(AV1451) in Neurodegenerative Disorders

hyperphosphorylation is a pathological feature of a group of neurodegenerative diseases known as tauopathies. The 18F-T807 (AV1451) molecular probe is a novel molecularly targeted imaging agent that exhibits high

parkinson's disease
  • 0 views
  • 01 Dec, 2021
  • 1 location
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) (DIAN-TU)

To assess the safety, tolerability, biomarker, cognitive, and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug improves disease-related biomarkers and slows the rate of progression of cognitive or clinical impairment.

cognitive impairment
positron emission tomography
dementia
mild cognitive impairment
mild dementia
  • 1 views
  • 10 Aug, 2022
  • 5 locations
Evaluation of the Efficacy of a Two-week EMST on Dysphagia in Parkinsonian Patients (EMST-PS)

This is an interventional therapy study designed to evaluate the efficacy of a two-week intervention, i.e. training with a specialized exhalation training device (called expiratory muscle strength training; EMST150 or EMST75; Aspire Products, Gainsville, FL) on swallowing function in patients with neurodegenerative Parkinsonian disorders. This study involves a routine endoscopic …

parkinson's disease
gaze palsy
atrophy
  • 0 views
  • 19 Apr, 2022
  • 2 locations
Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia (Lithium)

Frontotemporal dementia (FTD) is a progressive neurodegenerative illness that affects the frontal and anterior temporal lobes of the brain. Changes in behavior, including agitation, aggression, and repetitive behaviors, are common symptoms in FTD. The investigators currently do not have good medications to treat these symptoms in FTD, and the medications …

mini-mental state examination
aphasia
placebo pill
mental state exam
  • 108 views
  • 24 Feb, 2022
  • 1 location