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Found 23 clinical trials
Epidemiology and Pathophysiology of Parkinsonism in the Caribbeans

The primary aim of this study is to estimate the frequency and to characterize clinically atypical parkinsonism in the French West Indies and Guyana.

  • 0 views
  • 21 Jan, 2021
  • 2 locations
A Study to Assess if BIIB080 Can Change Clinical Dementia Rating-Sum of Boxes Scores, and BIIB080 Safety and Tolerability When Injected Into the Cerebrospinal Fluid of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age (CELIA)

In this study, researchers will learn more about a study drug called BIIB080. The study will focus on participants with mild cognitive impairment or mild dementia due to AD. The main question researchers are trying to answer is if BIIB080 can slow the worsening of AD more than placebo. It …

  • 0 views
  • 11 Aug, 2022
  • 1 location
The Influence of Sequential Tau Protein and Amyloid Plaque Imaging Changes on Stroke Prognosis and Cognitive Outcome

Amyloid plaques and tau protein are the landmarks of neurodegeneration in Alzheimer's disease (AD). On the other hand, it is reported that cerebral ischemia may induce amyloid plaques and tau

Accepts healthy volunteers
  • 0 views
  • 10 Oct, 2021
  • 1 location
The Influence of Vascular Burden, Amyloid Plaque and Tau Protein in Patients With Vascular Cognitive Impairment and Dementia With Tauopathy

Background and objects Amyloid plaques and tau protein are the landmarks of neurodegeneration in Alzheimer's disease (AD). On the other hand, it is reported that cerebral ischemia may induce

Accepts healthy volunteers
  • 0 views
  • 02 Mar, 2022
  • 1 location
Pilot Phase 1 Clinical Trial of PET Scanning in Tau Protein Deposition and Connectome Analysis in Traumatic Encephalopathy Syndrome (TES) Cohort With a Probable Chronic Traumatic Encephalopathy (CTE) Pattern of Neurodegenerative Disease (TACIT)

This pilot study aims to assess if participants that meet the criteria for a TES diagnosis have a specific tau deposition profile on PET scanning using the PET tau binding ligand - [18F] PI-2620. It is hoped this study will highlight potential diagnostic tests of TES diagnosis, the in-life correlate …

neuropsychological assessment
stroke
  • 0 views
  • 18 Sep, 2022
  • 1 location
The Influence of [18F]PMPBB3 and [18F]THK5351 PET Distribution Patterns on Post-stroke Cognitive Impairment

protein radiotracer without significant off-target binding to MAO-B. The investigators hypothesize that the neuroinflammation after acute stroke may induce the tau protein accumulation. In the current

Accepts healthy volunteers
  • 0 views
  • 10 Oct, 2021
  • 1 location
Topography Staging and Dual Phase Image Quantification of Tau PET in Cognitive Impairment Subjects

. This study will evaluate new quantitative methods with PMPBB3, by utilized dual phase scanning protocol to extract blood flow and Tau protein binding information, to evaluate appropriate reference

demented
amyloid
amyloidosis
tau protein
positron emission tomography
  • 1 views
  • 18 Feb, 2022
  • 1 location
MRI and PET Biomarkers for Cognitive Decline in Older Adults

cognitive testing in detecting subtle changes in the brain that precede cognitive decline. An addendum to this study includes additional PET scans to examine the relationship between tau protein in the

amyloid
mini-mental state examination
positron emission tomography
alzheimer's disease
Accepts healthy volunteers
  • 7 views
  • 24 Jan, 2022
  • 1 location
CARbon Dioxide Flooding to Reduce Postoperative Neurological Injury Following Surgery for Acute Type A Aortic Dissection (CARTA)

hydrolase L1 (UCH-L1) and Tau-protein (TAU)) before and after surgery. Quality of life, postoperative recovery and neurological function after ATAAD surgery. Primary outcomes in relation to retrograde

  • 0 views
  • 15 Mar, 2022
  • 1 location
PET Tau - Neurodegenerative Disease Imaging

The purpose of this study is to measure the amount of a protein in the brain known as tau using an imaging procedure called Positron Emission Tomography (PET/CT). Tau has been shown to build up in the brains of patients with injury to brain cells. This study looks at neurodegenerative …

cognitive impairment
neurodegenerative disorders
positron emission tomography
Accepts healthy volunteers
dementia
  • 21 views
  • 20 Apr, 2022
  • 1 location