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Found 319 clinical trials
Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery (ASTER)

Prospective multi-center phase 2b randomized placebo-controlled double-blinded interventional platform trial of two different pharmacologic therapies (intravenous Vitamin C or intravenous Acetaminophen) for patients with sepsis-induced hypotension or respiratory failure.

assisted ventilation
vasoconstrictors
vasopressor
respiratory failure
antibiotics
  • 0 views
  • 27 Apr, 2022
  • 8 locations
Immunotherapy With Ipilimumab and Nivolumab Preceded or Not by a Targeted Therapy With Encorafenib and Binimetinib (EBIN)

This is a multicenter, 2-arm open-label, randomized comparative phase II study. The objective of this trial is to prospectively evaluate whether a sequential approach with an induction period of 12 weeks with encorafenib + binimetinib followed by combination immunotherapy with nivolumab + ipilimumab improves progression free survival compared to combination …

metastatic melanoma
ipilimumab
measurable disease
BRAF
ct scan
  • 11 views
  • 16 Feb, 2022
  • 39 locations
CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

cancer remaining at surgery (either in the breast or underarm lymph nodes) after pre-operative chemotherapy and HER2-targeted therapy. Drugs used in chemotherapy, such as paclitaxel, work in different

ejection fraction
targeted therapy
neutrophil count
estrogen receptor
estrogen
  • 92 views
  • 25 Mar, 2022
  • 583 locations
(IMPACT II) Molecular Profiling and Targeted Therapy in Treating Patients With Metastatic Cancer

This randomized clinical trial studies how molecular profiling and targeted therapy work in treating patients with cancer that has spread to other places in the body compared to standard

cancer
neutrophil count
metastasis
carcinoma
liver metastasis
  • 20 views
  • 22 Jan, 2022
  • 1 location
Molecular Profiling and Matched Targeted Therapy for Patients With Metastatic Melanoma

This is a patient oriented translational research project aiming to improve clinical outcomes for patients with BRAF and NRAS wild-type unresectable Stage III or Stage IV metastatic melanoma who have progressed on, or are unable to receive standard therapy (in general, immunotherapy). Consecutive patients seen at three major clinics and …

cancer
targeted therapy
neutrophil count
mek inhibitor
NRAS
  • 0 views
  • 03 Dec, 2021
  • 2 locations
Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancer

Definitive chemoradiotherapy is the standard of care in unresectable esophageal or esophagogastric cancer. A multidisciplinary approach, including chemotherapy and radiotherapy, is important for these patients. Morerover, molecular targeting agents does not show clear efficacy in EC up to now. Nowadays, the pace of development of cancer immunotherapies is accelerating. Clinical …

  • 0 views
  • 06 Apr, 2021
  • 1 location
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

cns involvement
beta-human chorionic gonadotropin
ensartinib
interferon
myelosuppressive chemotherapy
  • 1029 views
  • 13 May, 2022
  • 103 locations
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

other cancer
tenofovir
multiple myeloma
fgfr inhibitor azd4547
adavosertib
  • 6567 views
  • 09 May, 2022
  • 925 locations
  • 7 views
  • 21 Jan, 2021
  • 1 location
Personalized Oncogenomics (POG) Program of British Columbia

targeted therapy. The investigators will use full genome sequencing to try to identify cancer "drivers" and corresponding drugs that may inhibit these pathways.

  • 0 views
  • 05 Feb, 2021
  • 1 location