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Found 333 clinical trials
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Assessing the Clinical Benefit of Molecular Profiling in Patients With Solid Tumors

Many patients are treated for advanced cancer without knowledge of underlying molecular features that might indicate FDA approved therapies or potential eligibility for biomarker-selected clinical trials. The Strata Trial (STR-001-001) has been initiated by Strata Oncology to evaluate the clinical benefit of systematic comprehensive genomic profiling for participants with advanced …

solid tumour
cancer
solid neoplasm
multiple myeloma
primary cancer
  • 24 views
  • 07 Oct, 2021
  • 40 locations
None
Attribution of Toxicities Due to Radiotherapy and Immuno-Biological Therapies

Every year, new molecular agents enter the market with more and more patients receiving these treatments, especially in the metastatic setting. These molecular agents could correspond to immunotherapy and modulators of signaling pathways. More than 50% of cancer patients will receive radiation therapy during the course of their illness, including …

  • 0 views
  • 25 Feb, 2021
  • 1 location
None
Investigation of the Human Immune Response in Normal Subjects and Patients With Disorders of the Immune System and Cancer

This protocol is being submitted to consolidate, update, and expand two previously approved protocols (77-C-0066 and 82-C-0044) into a single protocol. The purpose of this study is to examine the factors involved in the regulation of the immune system of healthy individuals and to define the abnormalities in this regulation …

platelet count
cancer
autoimmune disorder
blood transfusion
apheresis
  • 12 views
  • 14 Nov, 2021
  • 1 location
None
Prospective Study of MAstectomy With Reconstruction Including Robot Endoscopic Surgery

Robotic mastectomy and immediate reconstruction have been introduced recently in 2015. However, since robotic mastectomy is latest surgical technique, there is a lack of studies comparing conventional mastectomy and immediate reconstruction with robotic mastectomy prospectively. For this reason, this study is designed to establish a single institution cohort study that …

TP53
BRCA1
mastectomy
BRCA1/2
palb2
  • 0 views
  • 20 Jun, 2021
  • 1 location
None
Health Effects of CArdiac FluoRoscopy and MOderN RadIotherapy in PediatriCs - Radiotherapy

The goal of the HARMONIC-RT study is to evaluate late health and social outcomes of modern external beam radiotherapy techniques in paediatric patients, based on the setting-up of a European, long-term registry complemented by a biobank.

  • 0 views
  • 23 Mar, 2021
  • 5 locations
None
Survival Rate and Treatment Cost in Patients With Pancreatic Cancer With the Advent of New Chemotherapeutic Agents in Korea: An Analysis Using NHIS Database and K-PaC Registry Focusing on the Newest One Liposomal Irinotecan

The past 15 years, using National Health Insurance Service (NHIS) database and K-PaC registry, and to analyze the cost and cost-effectiveness along with the change in survival rate after the emergence of the aforementioned regimens, which is very important for policy decisions such as reimbursement of second-line treatment.

irinotecan
antineoplastic
  • 0 views
  • 12 Sep, 2021
  • 1 location
None
The Myeloid Neoplasms Biology and Outcome Project

The Myeloid Neoplasms Biology and Outcome Project (MyBOP) aims to establish a registry study for patients with myeloid neoplasms. It integrates clinical data, biological samples, socio-demographic information, long-term follow-up and patient reported outcomes in a structured manner for scientific purposes. The ultimate benefits are: Improvement of evidence-based clinical management of …

  • 0 views
  • 17 Oct, 2021
  • 1 location
None
Swiss Dermatology Network of Targeted Therapies (SDNTT)

The purpose of this study is to evaluate the long-term course of patients with psoriasis and psoriatic-arthritis in systemic treatments such as, methotrexate, cyclosporin A, fumaric acids, acitretin, systemic PUVA, etanercept, infliximab, adalimumab and ustekinumab. A patient will be included at first initiation of the treatment and will remain in …

acitretin
puva
adalimumab
methotrexate
cyclosporine
  • 14 views
  • 26 Jan, 2021
  • 6 locations
None
Target Therapies Resistance Molecular Profiling in Patients With Neoplastic Disease

The main purpose of this study is to define the molecular profile of selected solid tumors. From each participants will be collected biological materials for molecular analysis, including saliva, blood and vital tumor tissue derived form surgical or biopsy procedures. Whereas possible, vital tumor specimens will be inoculated and propagated …

lung cancer
metastasis
liver metastasis
cancer
sarcoma
  • 0 views
  • 21 Jan, 2021
  • 11 locations
None
Therapeutic ResistAnce and Clonal Evolution Assessed With Liquid Biopsy in ICIs Treated NSCLC Patients

To evaluate the predictive value of ctDNA in response, relapse for patients treated with immune checkpoint inhibitors or targeted therapy for ALK, ROS1, MET ex14 skipping.

lung cancer
metastasis
ROS1
cancer
carcinoma
  • 47 views
  • 27 Jan, 2021
  • 1 location