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Found 333 clinical trials
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Iscador Qu as Supportive Treatment in Colorectal Cancer (Union International Cancer Control UICC Stages II-IV)

Cancer Control, UICC stages II-IV), in addition to post-operative conventional oncological therapy (radio-, chemo-, targeted therapy) as compared to a parallel group with conventional therapy

  • 60 views
  • 08 Nov, 2020
  • 1 location
None
Carcinoma of Unknown Primary (CUP): A Comparison Across Tissue and Liquid Biomarkers

CUP team of any "actionable" genetic changes, which could potentially direct selection of a targeted therapy trial for that patient. Sequential blood samples will be collected to investigate genetic

  • 0 views
  • 12 Aug, 2021
  • 7 locations
None
The Relationship Between Pericardial Fat Thickness and Arterial Stiffness in HFpEF Patients

Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research …

  • 0 views
  • 26 Jan, 2021
  • 1 location
None
The Clinical Outcome and the Exploration of Related Biomarkers of Target Therapy in Metastasis Colorectal Cancer

Through clinical observation and data statistics, conclude the clinical outcome of target therapy in metastasis colorectal cancer and explore some biomarkers that relate to target therapy.

  • 3 views
  • 22 Jan, 2021
  • 1 location
None
Multi-layer Data to Improve Diagnosis Predict Therapy Resistance and Suggest Targeted Therapies in HGSOC

Chemotherapy resistance is the greatest contributor to mortality in advanced cancers and severe challenges remain in finding effective treatment modalities to cancer patients with metastasized and relapsed disease. High-grade serous ovarian cancer (HGSOC) is typically diagnosed at a stage where the disease is already widely spread to the abdomen and …

  • 0 views
  • 16 May, 2021
  • 1 location
None
Comparative Effectiveness of Targeted Therapy in RA Patients

The objective of a multicenter prospective observational study is to compare effectiveness and safety of biologic disease-modifying antirheumatic drugs and small molecular inhibitors in patients with moderately to severely active rheumatoid arthritis patients who have had an inadequate response or intolerace to methotrexate.

tocilizumab
antirheumatics
abatacept
DMARD
methotrexate
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Tumour Characterisation to Guide Experimental Targeted Therapy - National

The primary aim of TARGET National is to establish a national framework to offer molecular profiling of circulating tumour DNA and/or tumour tissue (optional) to patients with advanced solid cancers referred to any of the Experimental Cancer Medicine Centres (ECMCs) across the UK, in order to help decision making for …

investigational treatment
cancer treatment
targeted therapy
primary cancer
  • 0 views
  • 11 Nov, 2021
  • 9 locations
None
Optimization of Individualized Therapy for CRCs With Secondary RESISTance Towards Anti-EGFR Targeted Therapy Using an Avatar Model

In this exploratory phase II trial, the possibility of a personalized treatment after resistance to cetuximab will be evaluated. Therefore, tumor material of all patients shall be obtained, transferred into avatars and treated the same way as in the patient until resistance arises. These resistant tumor cells are subsequently treated …

adenocarcinoma
EGFR
tumor cells
combinations
adenocarcinoma of colon
  • 6 views
  • 21 Jan, 2021
  • 1 location
None
Non-interventional Study of Cabozantinib in Adults With Advanced Renal Cell Carcinoma

The objective of this study is to understand the utilization of cabozantinib in subjects with advanced renal cell carcinoma (RCC) following prior VEGF-targeted therapy in real life settings in

cabozantinib
vegf
growth factor
carcinoma
targeted therapy
  • 148 views
  • 17 Nov, 2021
  • 142 locations
None
Real-world Study for Patients With Advanced Hepatobiliary Tumors

The investigators design a large sample size study in the real-world to explore whether targeted therapy and immunotherapy can improve the survival, quality of life and drug safety of patients

  • 0 views
  • 27 Jan, 2021
  • 1 location