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Found 323 clinical trials
CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition (Cyto-KIK)

The purpose of this study is to determine if the use of immunotherapy nivolumab and the targeted therapy cabozantinib prior to removal of the kidney, will increase the number subjects who are

targeted therapy
nivolumab
nephrectomy
cancer
kidney cancer
  • 42 views
  • 22 Apr, 2022
  • 2 locations
Pembrolizumab, Lenvatinib and Chemotherapy After TKIs in NSCLC

combination pembrolizumab with lenvatinib and chemotherapy in NSCLC patients with sensitizing EGFR, ALK, or ROS1 genetic aberration refractory to standard targeted therapy.

targeted therapy
ROS1
pemetrexed
pembrolizumab
carcinoma
  • 0 views
  • 18 Dec, 2021
  • 1 location
Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and Pediatric Participants With Neurofibromatosis Type 1

inhibitor of MEK1/2, which is expected to be a targeted therapy for the treatment of advanced solid tumors and neurofibromatosis type 1.

  • 0 views
  • 11 May, 2022
  • 7 locations
Fractionated Gemtuzumab Ozogamicin in Treating Measurable Residual Disease in Patients With Acute Myeloid Leukemia

monoclonal antibody, called gemtuzumab, linked to a chemotherapy drug, called ozogamicin. Gemtuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of

residual tumor
leukemia
gemtuzumab ozogamicin
cancer
remission
  • 5 views
  • 19 Apr, 2022
  • 1 location
Imaging CCR2 Receptors With 64Cu-DOTA-ECL1i in Head and Neck Cancer

CCR2 is a significant prognostic biomarker in head and neck cancer. Currently there is no clinical biomarker to study CCR2, its prognostic significance or to select patients for CCR2-targeted

  • 0 views
  • 01 Mar, 2022
  • 1 location
  • 0 views
  • 22 Mar, 2022
  • 1 location
A Comparative Study of Pravastatin vs Placebo as Primary Prevention of Severe Subcutaneous Breast Fibrosis in Hyper-radiosensitive Identified Patients With Breast Cancer (PRAVAPREV-01)

development By offering a statin targeted therapy to the high-risk patients identified.

breast-conserving surgery
invasive carcinoma
carcinoma
  • 0 views
  • 21 Mar, 2022
  • 7 locations
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy (PEACH)

molecular targeted therapy in combination with adoptive cell therapy (Total tumor mRNA-pulsed autologous Dendritic Cells (DCs) (TTRNA-DCs), Tumor-specific ex vivo expanded autologous lymphocyte transfer

depo-provera
filgrastim
granulocyte colony stimulating factor
cancer
colony stimulating factor
  • 0 views
  • 14 May, 2022
  • 2 locations
Donafenib for Recurrent Cervical Cancer

This study is to evaluate the safety and tolerability of Donafenib combined with paclitaxel and platinum ± programmed death 1 monoclonal antibody (PD-1 antibody) in patients with recurrent cervical cancer.

measurable disease
metastasis
cancer
paclitaxel
absolute neutrophil count
  • 0 views
  • 19 Apr, 2022
  • 1 location
Niraparib Plus Anlotinib for Recurrent Ovarian Cancer

This is a phase II trial to explore efficacy and safety of niraparib in combination with anlotinib based on CA 125 level in newly diagnosed ovarian cancer. After completion of 1st-line platinum-based chemotherapy with a normal CA-125 concentration, in patients with CA-125 increased > 35U/ml, and with no evidence of …

direct bilirubin
bevacizumab
recurrent ovarian cancer
cancer of the ovary
cancer
  • 0 views
  • 29 Apr, 2022
  • 1 location