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Found 327 clinical trials
Feasibility and Safety of IMP321 for Advanced Stage Solid Tumors

-peritoneal therapy; combination of chemotherapy and/or immunotherapy/targeted therapy with active immunotherapy

metastatic malignant solid tumor
solid tumor
targeted therapy
aptt
avelumab
  • 5 views
  • 22 Jul, 2021
  • 1 location
Personalized Targeted Preparative Regimen Before T-depleted Allogeneic HSCT in Children With Chemoresistent Acute Leukemias

The purpose of this study is to evaluate the safety and efficiency of personalized targeted therapy in combination with high-dose chemotherapy as part of a preparative regimen before T-depleted

  • 0 views
  • 26 Jan, 2021
  • 1 location
Patient Decision-making About Precision Oncology in Veterans With Advanced Prostate Cancer

This project proposes to understand and improve Veterans' decision-making in precision oncology (germline testing, somatic tumor testing, and targeted therapy) for advanced prostate cancer. As

  • 0 views
  • 08 Jul, 2022
  • 1 location
A Phase II Study of Chemoradiotherapy With Nimotuzumab in Unresectable Esophageal Cancer

This phase II clinical study is designed to evaluate the 1 year local tumor control rates after the targeted therapy of intensity-modulated radiation therapy synchronized chemotherapy with

carcinoma
squamous cell carcinoma
chemotherapy regimen
esophagus cancer
chemoradiotherapy
  • 1 views
  • 28 Oct, 2021
  • 1 location
CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition (Cyto-KIK)

The purpose of this study is to determine if the use of immunotherapy nivolumab and the targeted therapy cabozantinib prior to removal of the kidney, will increase the number subjects who are

pet scan
tubal ligation
carcinoma
heparin
nephrectomy
  • 42 views
  • 22 Apr, 2022
  • 2 locations
Pembrolizumab, Lenvatinib and Chemotherapy After TKIs in NSCLC

combination pembrolizumab with lenvatinib and chemotherapy in NSCLC patients with sensitizing EGFR, ALK, or ROS1 genetic aberration refractory to standard targeted therapy.

carboplatin
carcinoma
squamous cell carcinoma
proto-oncogene tyrosine-protein kinase ros
EGFR
  • 0 views
  • 18 Dec, 2021
  • 1 location
Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and Pediatric Participants With Neurofibromatosis Type 1

inhibitor of MEK1/2, which is expected to be a targeted therapy for the treatment of advanced solid tumors and neurofibromatosis type 1.

solid tumors
  • 0 views
  • 10 Aug, 2022
  • 7 locations
Calcium Channel Blockade in Primary Aldosteronism

zona glomerulosa calcium channels that results in aldosterone production. This finding raises the possibility that calcium channel antagonists may be a targeted therapy to reduce aldosterone production

aldosterone
adrenal venous sampling
renin
amlodipine
hyperaldosteronism
  • 0 views
  • 16 Dec, 2021
  • 1 location
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy (PEACH)

molecular targeted therapy in combination with adoptive cell therapy (Total tumor mRNA-pulsed autologous Dendritic Cells (DCs) (TTRNA-DCs), Tumor-specific ex vivo expanded autologous lymphocyte transfer

cancer
neutrophil count
colony stimulating factor
bone marrow procedure
granulocyte colony stimulating factor
  • 0 views
  • 14 May, 2022
  • 2 locations
  • 0 views
  • 22 Mar, 2022
  • 1 location