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Found 319 clinical trials
Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy

patients can safely have less treatment. The investigators therefore propose a real-world, single arm, multicentre trial evaluating 6 months of HER2 targeted therapy, for patients with early-stage, HER2

EGFR
epidermal growth factor receptor
her2/neu-positive breast cancer
erbb2
HER2
  • 0 views
  • 13 May, 2022
  • 1 location
QUALIOR Feasibility and Efficacy of a Supervised Home-based Standard Physical Exercise Program (QUALIOR)

This phase II-III study will be randomized (2:1) patients starting first-line oral targeted therapies (OTT) for metastatic cancer between an individualized supervised physical exercise programs (SPEP) by a personal coach, and recommended physical exercises via a booklet. Eligible patients will have received 2 lines of metastatic chemotherapy, Eastern Cooperative Oncology …

  • 6 views
  • 31 Jan, 2022
  • 3 locations
Prophylaxis of Diarrhea in Adult Cancer Patients Receiving Targeted Cancer Therapy (OnTARGET)

A 24-week, (two 12-week stages), randomized, placebo-controlled, double-blind study to evaluate the safety and efficacy of crofelemer in providing prophylaxis of diarrhea in adult patients with solid tumors treated with targeted cancer therapy-containing treatment regimens. Diarrhea grading will be done according to the National Cancer Institute Common Terminology Criteria for …

  • 8 views
  • 13 May, 2022
  • 14 locations
A Study Using Regorafenib as Second or Third Line Therapy in Metastatic Medullary Thyroid Cancer

This research study is studying a targeted therapy as a possible treatment for thyroid cancer. A targeted therapy is a type of treatment that uses drugs or other substances to identify and

medullary thyroid carcinoma
cancer
measurable disease
platelet count
renal function
  • 11 views
  • 10 Mar, 2022
  • 1 location
LY3214996 in Patients With AML Who Are Not Candidates for Standard Therapy

This research study is evaluating a targeted therapy as a possible treatment for acute myeloid leukemia (AML) that has returned or not responded to standard treatment.

cancer
refractory acute myeloid leukemia (aml)
direct bilirubin
  • 0 views
  • 22 Oct, 2021
Micro-Ultrasound for the Detection and Localization of Prostate Cancer Tumors in Patients Undergoing Radical Prostatectomy

tissue around it). Usually multiparametric magnetic resonance imaging is used for the detection and targeted therapy of prostate cancer, but its accuracy remains imperfect. Micro-ultrasound may be

  • 0 views
  • 06 Nov, 2021
  • 1 location
Safety and Efficacy of Camrelizumab (Anti-PD-1 Antibody) in Recurrent HCC After Liver Transplantation

transplantation. All of the enrolled patients have a background of liver transplantation for HCC. Due to the tumor recurrence, patients are not suitable for curative surgical resection, and targeted therapy

immune globulin
sorafenib
hepatocellular carcinoma
immunohistochemistry
metastasis
  • 0 views
  • 15 May, 2022
  • 1 location
  • 0 views
  • 08 Nov, 2020
  • 1 location
CAcTUS - Circulating Tumour DNA Guided Switch (CAcTUS)

The stay aims to determine whether switching from targeted therapy to immunotherapy based on a decrease in levels of circulating tumour DNA in the blood, will improve the outcome in melanoma

braf v600e mutation
malignant melanoma of skin
BRAF
melanoma skin
human chorionic gonadotropin
  • 0 views
  • 06 Feb, 2022
  • 1 location
Detect V / CHEVENDO (Chemo vs. Endo)

Chemo- versus endocrine therapy in combination with dual HER2-targeted therapy of Herceptin (trastuzumab) and Perjeta (pertuzumab) plus Kisqali (ribociclib) in patients with HER2 positive and

serum pregnancy test
capecitabine
metastasis
vinorelbine
endocrine therapy
  • 35 views
  • 24 Jan, 2022
  • 1 location