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Found 67 clinical trials
Tamoxifen Therapy to Treat Pulmonary Arterial Hypertension (T3PAH)

The main purpose of this clinical trial is to examine the feasibility and effects of tamoxifen in subjects with pulmonary arterial hypertension (PAH). The study will evaluate how well the drug

hypertension
tapse
walk tests
connective tissue disease
  • 82 views
  • 26 Apr, 2022
  • 1 location
FES Imaging to Optimize Tamoxifen for Metastatic Breast Cancer

receptor signaling and transcriptional regulation that is always "turned on" despite the absence of estrogen. Patients with ESR1 mutations are expected to have decreased binding affinity for tamoxifen and

  • 4 views
  • 21 Feb, 2022
  • 1 location
Tamoxifen Versus Etoposide After First Recurrence in GBM Patients

The investigator propose a single-center randomized phase II controlled study designed to compare the management of first recurrence of GBM using etoposide versus tamoxifen.

  • 0 views
  • 24 Apr, 2022
  • 1 location
Pembrolizumab and Tamoxifen With or Without Vorinostat for the Treatment of Estrogen Receptor Positive Breast Cancer

This phase II trial studies how well pembrolizumab and tamoxifen with or without vorinostat work for the treatment of estrogen receptor positive breast cancer. Immunotherapy with monoclonal

  • 0 views
  • 22 Mar, 2022
  • 1 location
Oral Tamoxifen vs. TamGel vs. Control in Women With Atypical Hyperplasia or Lobular Carcinoma In Situ

The investigators plan to prospectively study breast tissue changes after a short course of Tamoxifen (Tam).

  • 0 views
  • 26 Sep, 2021
  • 1 location
Tamoxifen for Well Differentiated Neurodendocrine Tumors and Hormone Receptor Positive Expression

This is a single-arm, single-stage clinical study of tamoxifen for patients with well-differentiated neuroendocrine tumors and radiological progression with positive (> 1%) HR (estrogen and

neutrophil count
measurable disease
pancreatic net
who 2017
platelet count
  • 0 views
  • 05 May, 2022
  • 1 location
Fertility Preservation Using Tamoxifen and Letrozole in Estrogen Sensitive Tumors Trial (TALES)

treatment has been associated with improved quality of life, with a potential ability to reduce long-term decision-related regret in cancer survivors. Though letrozole plus gonadotropin and and tamoxifen

cancer
estrogen
ovarian stimulation
oocyte retrieval
gonadotropin
  • 46 views
  • 09 May, 2022
  • 1 location
Dose-determining and Dose-confirmatory Study to Investigate the Optimal Dose of Tamoxifen in Breast Cancer Patients According to Genotype Status of TCF20 rs932376

The investigators hypothesize that the TCF20 rs932376 locus controls endoxifen levels in estrogen receptor (ER)-positive breast cancer patients on tamoxifen therapy and that the requirement of

progesterone
estrogen
tamoxifen
estrogen receptor
  • 0 views
  • 22 Jul, 2021
  • 1 location
Testing an Active Form of Tamoxifen (4-hydroxytamoxifen) Delivered Through the Breast Skin to Control Ductal Carcinoma in Situ (DCIS) of the Breast

This randomized phase IIB trial studies how well tamoxifen or afimoxifene works in treating patients with estrogen receptor positive breast cancer. Estrogen can cause the growth of breast cancer

neutrophil count
cancer
core needle biopsy
tumor cells
afimoxifene
  • 263 views
  • 25 Feb, 2022
  • 6 locations
A Study of TY-302 in Patients With Advanced Solid Tumors

The primary objective of this study is to evaluate the safety and tolerability of TY-302 single and the combination with Tamoxifen in dose-escalation and dose-expansion study.The drugs involved

  • 0 views
  • 26 May, 2022