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Found 35 clinical trials
The Effects of Interleukin-1 Blockade On Exercise Capacity In Patients With Recently Decompensated Systolic Heart Failure (REDHART2)

patients with recently decompensated systolic heart failure and increased systemic inflammation.

hscrp
ejection fraction
anakinra
edema
  • 0 views
  • 22 Sep, 2022
  • 1 location
Effect of Music on Cardiopulmonary Exercise Capacity in Heart Failure Patients (MUSIC-CPX)

The study aims to assess the effect of music on the heart resulting in a change in their exercise capacity among systolic heart failure patients undergoing Cardiopulmonary Exercise testing.

  • 0 views
  • 20 Sep, 2022
  • 1 location
Electrostimulation of Skeletal Muscles in Patients Listed for a Heart Transplant

Heart transplantation is the best way to treat terminal heart failure, which can improve the quality and life expectancy of patients, as well as contribute to their social and labor rehabilitation. Actually, the procedure of heart transplantation is a complex procedure that requires the coordinated work of cardiologists, cardiac surgeons, …

heart disease
heart failure
  • 0 views
  • 26 Jan, 2021
  • 1 location
Neuromodulation of Inflammation and Endothelial Function

Heart failure with reduced ejection fraction (HFrEF) is a major cause of mortality in United States. Aging is a major risk factor for adverse outcomes associated with HFrEF, with majority of the patient's over the age of 50, continuing to experience symptoms, reduced exercise capacity and poor quality of life. …

diastolic dysfunction
systolic heart failure
ejection fraction
chronic heart failure
  • 0 views
  • 27 May, 2022
  • 1 location
His-bundle Pacing vs. Right Ventricular Apical Pacing in Patients With Reduced Ejection Fraction (HIS-PrEF)

The study compares standard right ventricle apical pacing with so called His-bundle pacing, for patients with slightly or moderately reduced ejection fraction and atrioventricular block requiring pacemaker therapy. The primary outcome is left ventricular ejection fraction measured after 6 months.

  • 0 views
  • 24 Mar, 2022
  • 3 locations
Optimising Pacing for Contractility 2

The investigators have demonstrated that they can reliably identify an optimum heart rate range for contractility of the left ventricle in patients with chronic heart failure (CHF). They have also demonstrated in an acute cross-over and a small parallel group feasibility study that keeping the heart rate in this range …

walk test
heart failure
left ventricular systolic dysfunction
exercise stress test
chronic heart failure
  • 33 views
  • 10 Oct, 2021
  • 1 location
Mechanistic Studies of Nicotinamide Riboside in Human Heart Failure

Preliminary animal studies by ourselves and others suggest that the dietary supplement, nicotinamide riboside (NR), may improve cardiac function in heart failure (HF) by increasing cellular levels of its metabolite, nicotinamide adenine dinucleotide (NAD+, NADH). This Study will address a key gap in current knowledge by assessing the mechanisms through …

  • 0 views
  • 20 Jun, 2021
  • 1 location
Thoracentesis to Alleviate Cardiac Pleural Effusion

The present study will examine the comparative effectiveness of two treatment strategies currently used in the treatment of patients with systolic heart failure presenting with pleural effusion

heart failure
systolic heart failure
ejection fraction
thoracentesis
  • 9 views
  • 04 Oct, 2022
  • 11 locations
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction (MUSIC-HFrEF1)

It is believed that targeted SERCA2a enzyme replacement in HFrEF patients will correct defective intracellular Ca2+ hemostasis, resulting in improved cardiac contractile function and energetics which will, in turn, translate to improved clinical outcomes. Additionally, it is hypothesized that correcting SERCA2a dysfunction will also improve coronary blood flow through correction …

calcium
cardiomyopathy
ejection fraction
heart failure
  • 0 views
  • 04 Oct, 2022
  • 1 location
Effects of Postural Balance Exercises in Patients With Heart Failure

In this study, the effects of core stabilization and computerized wobble board exercise training programs on postural balance and functional exercise capacity in patients over 60 years of age with heart failure will be investigated.

heart failure
  • 0 views
  • 15 Jun, 2022
  • 1 location