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Found 40 clinical trials
Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion: a Randomized Controlled Multi-center Trial (ADAPT)

. Although the prognostic role of septic cardiomyopathy remains debated, sepsis-induced left ventricular (LV) systolic dysfunction may be severe and associated with tissue hypoperfusion, while it appears to

hypoperfusion
ejection fraction
dobutamine
vasoconstrictors
cardiomyopathy
  • 0 views
  • 15 Oct, 2022
  • 15 locations
Cardiac Contractility Modulation in Chagas Heart Disease (FIX-Chagas)

failure, severe systolic dysfunction, and non-LBB have better clinical and functional responses when undergoing implantation of a CCM device than when undergoing cardiac resynchronization therapy.

heart failure
heart disease
left bundle branch block
cardiac resynchronization therapy
systolic dysfunction
  • 0 views
  • 07 Oct, 2022
  • 1 location
Phase II Trial of Cardioprotective Prophylaxis With Combination of Beta Blocker and Angiotensin-Converting Enzyme Inhibitors During Intensive Chemotherapy for Patients With Newly Diagnosed Acute Myeloid Leukemia (AML 001)

hypothesize that up-titrating study agents to maximum tolerated dosage at the time of induction (starting treatment for AML) will prevent the development of systolic dysfunction as determined on serial

daunorubicin
anthracyclines
gilbert's syndrome
induction chemotherapy
ejection fraction
  • 0 views
  • 23 Oct, 2022
  • 1 location
Ivabradine for Heart Rate Control In Septic Shock

contractility and blood pressure complicate their use during septic shock, particularly because about one-half of patients exhibit a septic-associated systolic dysfunction, which often requires the use of

  • 6 views
  • 20 Jul, 2021
  • 1 location
Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients With Permanent Atrial Fibrillation (RAFT-PermAF)

Atrial fibrillation (AF) and heart failure (HF) are two common heart conditions that are encountered with an increase in death and suffering. When both these two conditions occur in a patient, the patient's prognosis is poor with a reduced quality of life and impaired heart function. These patients have enlarged …

fibrillation
medical therapy
heart failure
secondary prevention
atrial fibrillation
  • 77 views
  • 11 Apr, 2022
  • 13 locations
Prediction and Maintenance of Sinus Rhythm Among Atrial Fibrillation Patients

Atrial fibrillation (AF) is the most common heart rhythm disorder seen in clinical practice, with an estimated 2.7-6.1 million people in the U.S. affected by the disorder [1]. Previous studies have demonstrated that left atrial volume is a predictive measure of incident atrial fibrillation [2]. This study aims to add …

cardioversion
fibrillation
  • 0 views
  • 30 Sep, 2021
  • 1 location
MYTHS - MYocarditis THerapy With Steroids (MYTHS)

This is a phase III, multi-center international, single blind randomized controlled trial to test the efficacy of pulsed intravenous (IV) methylprednisolone versus standard therapy on top of maximal support in patients with Acute myocarditis (AM).

  • 0 views
  • 14 Jul, 2022
  • 14 locations
Lokelma for RAAS Maximisation in CKD & Heart Failure. (LIFT)

Background: CKD in patients with heart failure (HF) is common and associated with poor prognosis. Despite evidence of benefit with Renin-Angiotensin-Aldosterone-System inhibitor (RAASi) agents, they are avoided due to fear of hyperkalaemia. New potassium binders, e.g. Sodium Zirconium Cyclosilicate (SZC), reduce incidence of hyperkalaemia in CKD-HF patients and hence may …

aldosterone
heart failure
  • 0 views
  • 14 Mar, 2022
Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis

The aim of the study is to evaluate coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and proportion of overt microvascular disease, defined as depressed CFR as well as elevated IMR in patients with cardiac amyloidosis. The second objective of this study is to compare results of non-invasive test …

amyloidosis
depressed
  • 44 views
  • 07 Oct, 2022
  • 1 location
The Role of Sympathetic Tone Regarding the Anatomical and Functional Recovery of the Left Ventricle in TakoTsubo Syndrome

TakoTsubo Syndrome (TTS) constitutes an increasingly recognised, heterogenous clinical entity which is associated with considerable short-term mortality. In addition, emerging evidence suggests that, in the long term, TTS can induce the expression of a phenotype similar to HFpEF . Apart from the typical (apical left ventricular) type, the current TTS …

  • 0 views
  • 28 Jan, 2021
  • 1 location