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Found 12 clinical trials
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Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas

adenoma or hyperplasia associated with diabetes mellitus/ impaired glucose tolerance and/or uncontrolled systolic hypertension.

diabetes
adenoma
corticotropin
hyperplasia
hypercortisolism
  • 0 views
  • 22 Oct, 2021
  • 54 locations
None
Treatment of Hypertension During Sleep

On the basis of new evidence on the relationship between achieved office blood pressure (BP) measurements (OBPM) and the risk of cardiovascular disease (CVD) morbidity and mortality documented in the SPRINT trial, the recent 2017 guidelines of the American College of Cardiology (ACC) and the American Heart Association (AHA) have …

systolic blood pressure
diabetes
hypertension
ambulatory blood pressure monitoring
cardiovascular disease
  • 19 views
  • 08 Jan, 2022
  • 12 locations
None
Impact of the Reduction in Antihypertensive Treatment on Total Mortality in Frail Subjects With Low Systolic Blood Pressure: Study in Subjects Over 80 Years Living in Nursing Homes

The investigators hypothesize that a gradual reduction in antihypertensive treatment in nursing home (NH) patients with low systolic blood pressure (SBP) can improve survival through a controlled increase in SBP and a decrease in secondary morbidity due to 'overmedication'. Accordingly, the investigators propose a randomized, case/control trial in NH patients …

systolic blood pressure
hypertension
antihypertensive drugs
  • 10 views
  • 07 Dec, 2021
  • 2 locations
None
A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients

This is a double-blinded randomized controlled study assessing the effectiveness of isometric handgrip therapy. Approximately 230 patients who present with a Systolic Blood Pressure reading of 149mmHg and who have not taken antihypertensive medication for more than 30 days will be enrolled.

  • 0 views
  • 04 Nov, 2021
  • 13 locations
None
Sympathetic Regulation of Large Artery Stiffness in Humans With ISH

Stiffening of your blood vessels, particularly the large vessels from your heart (called the aorta and carotids) you age contributes to the development of cardiovascular disease (CVD) such as heart attack and stroke. Nerve activity from your brain to your body also increases with advancing age but it is unknown …

  • 0 views
  • 22 Jun, 2021
  • 2 locations
None
Preload and Autonomic Responses With Cardiac Neuromodulation Therapy (CNT) (CS-06)

This investigation will evaluate the effect of RV pacing lead position on cardiac function and the modulation of the autonomic nervous system with Cardiac Neuromodulation Therapy (CNT) pacing signals. The study will be performed acutely prior to a pacemaker implant.

hypertension
electrocardiogram
  • 0 views
  • 14 Oct, 2021
  • 1 location
None
Cardiac Neuromodulation Therapy (CNT) "Washout" Sub-Study

This washout protocol is structured as a sub-study for patients willing to participate after finishing the double blind randomised phase of the clinical trial, NCT02837445. Devices will be turned off for a week approximately. Patients will have their PHC programmed to automatically turn off 24 hr after a medical and …

  • 0 views
  • 13 Jan, 2022
  • 1 location
None
OMILQ: Osteopathic Manipulation to Increase Lactation Quantity (OMILQ)

This study is designed to investigate whether using osteopathic manipulation can increase the milk supply in lactating women.

  • 1 views
  • 13 Mar, 2021
  • 1 location
None
Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults

Aging is the primary risk factor for cardiovascular diseases (CVD), the number one cause of death in developed societies. Systolic blood pressure (SBP) increase with age and is a key intermediary factor linking aging to increased CVD risk. The primary mechanisms underlying the age-associated increase in SBP is stiffening of …

caloric restriction
body mass index
total cholesterol
fatigue
fasting
  • 82 views
  • 15 May, 2021
  • 1 location
None
MOCHA Moving Forward: a CBPR Investigation of Chronic Disease Prevention in Older Low-income African-American Men

The overall goal of the research is to discover how to reduce chronic disease health disparities among older (ages 35-70) low-income African-American men more effectively. To achieve this goal, we are conducting formative exploratory research with middle-aged, low-income African-American men; testing two versions of a novel community-developed intervention, MOCHA and …

  • 15 views
  • 22 Jan, 2021
  • 2 locations