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Found 46 clinical trials
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Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects

study how NR affects skeletal muscle function in people with heart failure. Eligibility: Adults ages 18-70 with clinically stable systolic heart failure

cardiopulmonary exercise testing
chronic heart failure
radionuclide ventriculography
systolic heart failure
heart failure
  • 77 views
  • 09 Apr, 2019
  • 1 location
ECG Belt vs. Echocardiographic Optimization of CRT

Cardiac resynchronization therapy (CRT) has been a valuable intervention for patients with systolic heart failure for over 15 years. Despite years of research, there is a still a 25-40% non

cardiac resynchronization therapy
  • 0 views
  • 26 May, 2021
  • 1 location
Mechanistic Clinical Trial of Advanced Imaging for CRT

This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.

angiography
MRI
  • 7 views
  • 23 Jan, 2021
  • 1 location
Pharmacodynamic Effects of Sacubitril/Valsartan on Natriuretic Peptides Angiotensin and Neprilysin

The study measure multiple neurohormones in patients with heart failure being treated with Sacubitril/Valsartan in increasing doses over an 8 week period.

ejection fraction
angiotensin
chronic heart failure
sacubitril/valsartan
  • 5 views
  • 23 Jan, 2021
  • 1 location
Hypoxic Conditioning in Heart Failure

Heart failure impairs quality of life and exercise capacity, despite an optimal medical therapy. Alternative methods, like hypoxic conditioning coupled to exercise training, must be explored and describe

medical therapy
  • 0 views
  • 24 Jan, 2021
  • 1 location
Multi-lead ECG to Effectively Optimize Resynchronization Devices: New CRT Recipients

Cardiac resynchronization therapy (CRT), or atrial-synchronized biventricular (BiV) pacing, is an FDA-approved device therapy option for heart failure (HF) patients with reduced left ventricular ejection fraction and electrical dyssynchrony. A traditional CRT device has pacing leads implanted within the right atrium (RA), the right ventricle (RV), and within a coronary …

ejection fraction
medical therapy
cardiac resynchronization therapy
  • 0 views
  • 27 May, 2021
  • 2 locations
Acute Changes in Bioimpedance During Cardiac Resynchronization Therapy

This study aims at Optimizing measured parameters to reflect underlying pathology in dyssynchronous hearts. This is an experimental study in patients were bioimpedance measurements are performed during implantation.

cardiac resynchronization therapy
  • 3 views
  • 22 Jan, 2021
  • 1 location
Evaluate the Effect of Injectable Neucardin on the Cardiac Function of Subjects With Chronic Systolic Heart Failure

pg/ml and female patients with NT-proBNP 4000 pg/ml, NYHA II-III chronic systolic heart failure, and to confirm its efficacy and safety.

  • 0 views
  • 28 Jul, 2021
  • 2 locations
Intracoronary Infusion of BM-Derived Mononuclear Cells in Patients With Large Acute Myocardial Infarction

Large acute myocardial infarctions are the most frequent cause of subsequent systolic heart failure. Some evidence exists on the improvement after intracoronary administration of bone

acute myocardial infarction
heart failure
  • 8 views
  • 07 Nov, 2020
  • 1 location
Early Versus Emergency Left Ventricular Assist Device Implantation in Patients Awaiting Cardiac Transplantation

The aim of the study is to assess whether, in patients who are listed for cardiac transplantation in transplantable (T) status, early implantation of a left ventricular assist device is superior to the current therapeutic strategy of medical heart failure therapy and assist device implantation only after serious deterioration of …

  • 31 views
  • 23 Jan, 2021
  • 43 locations