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Found 35 clinical trials
Featured trial
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects

study how NR affects skeletal muscle function in people with heart failure. Eligibility: Adults ages 18-70 with clinically stable systolic heart failure

heart failure
cardiopulmonary exercise testing
chronic heart failure
radionuclide ventriculography
systolic heart failure
  • 311 views
  • 09 Apr, 2019
  • 1 location
Cardiovascular Effects of Preferred Home-based Exercise Training in Systolic Heart Failure

The aim of the study is I. To assess whether an individualized exercise training program is superior as compared to usual care with respect to exercise tolerance, II. to assess whether intervention tools that aim to increase exercise adherence are superior to an individualized exercise training alone with respect to …

ejection fraction
medical therapy
systolic heart failure
  • 0 views
  • 08 Oct, 2021
  • 1 location
Multi-intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Heart Failure With Reduced Ejection Fraction PRIME-HFrEF Study

This study is an exploratory clinical study to observe the safety and efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in the heart failure patients with reduced ejection fraction. The study was a 12 months single center, randomized, double-blind, placebo-controlled trial that included 12 weeks of treatment, …

  • 0 views
  • 24 Nov, 2021
  • 1 location
Effects of CRT Optimization as Assessed by Cardiac MR

Cardiac resynchronization therapy (CRT), or atrial-synchronized biventricular (BiV) pacing, is an FDA-approved device therapy option for heart failure (HF) patients with reduced left ventricular ejection fraction and electrical dyssynchrony. A traditional CRT device has pacing leads implanted within the right atrium (RA), the right ventricle (RV), and within a coronary …

  • 0 views
  • 04 Oct, 2021
  • 2 locations
Mechanistic Clinical Trial of Advanced Imaging for CRT

This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.

MRI
angiography
  • 7 views
  • 26 Feb, 2022
  • 1 location
Multi-lead ECG to Effectively Optimize Resynchronization Devices: New CRT Recipients (METEOR-CRT)

Cardiac resynchronization therapy (CRT), or atrial-synchronized biventricular (BiV) pacing, is an FDA-approved device therapy option for heart failure (HF) patients with reduced left ventricular ejection fraction and electrical dyssynchrony. A traditional CRT device has pacing leads implanted within the right atrium (RA), the right ventricle (RV), and within a coronary …

cardiac resynchronization therapy
ejection fraction
medical therapy
  • 0 views
  • 14 Jun, 2022
  • 2 locations
Early Versus Emergency Left Ventricular Assist Device Implantation in Patients Awaiting Cardiac Transplantation

The aim of the study is to assess whether, in patients who are listed for cardiac transplantation in transplantable (T) status, early implantation of a left ventricular assist device is superior to the current therapeutic strategy of medical heart failure therapy and assist device implantation only after serious deterioration of …

  • 33 views
  • 25 Jan, 2022
  • 16 locations
Intravenous Iron in Patients With Systolic Heart Failure and Iron Deficiency to Improve Morbidity & Mortality (FAIR-HF2)

The purpose of this study is to determine whether intravenous iron supplementation using ferric carboxymaltosis (FCM) reduces hospitalisation and mortality in patients with iron deficiency and heart failure.

iron deficiency anemia
heart failure
iron
systolic heart failure
chronic heart failure
  • 13 views
  • 24 Feb, 2022
  • 32 locations
ANTHEM-HFrEF Pivotal Study

A multi-center randomized controlled clinical trial to evaluate Autonomic Regulation Therapy with the VITARIA system in patients with symptomatic heart failure and reduced ejection fraction.

b-type natriuretic peptide
nt-probnp
heart failure
walk test
medical therapy
  • 186 views
  • 15 Jun, 2022
  • 22 locations
Cryoballoon Ablation Versus Medical Therapy in Patients With Heart Failure and Atrial Fibrillation

Rationale Atrial fibrillation (AF) and heart failure (HF) can cause each other and sustain each other. Combined, the two diseases negatively influence each other's prognosis and lead to higher mortality. Studies in HF patients in which the AF burden is reduced by AF ablation show promising results toward improved prognosis, …

  • 0 views
  • 24 Mar, 2021
  • 2 locations