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Found 288 clinical trials
Trial Comparing Irradiation Plus Long Term Adjuvant Androgen Deprivation With GnRH Antagonist Versus GnRH Agonist Plus Flare Protection in Patients With Very High Risk Localized or Locally Advanced Prostate Cancer

infections; assessment of relative treatment effect on secondary efficacy endpoints (clinical progression, time to next line of systemic therapy, time on therapy, overall and cancer specific

androgens
testosterone
adenocarcinoma
adenocarcinoma of prostate
luteinizing hormone-releasing hormone agonist
  • 135 views
  • 23 Jan, 2021
  • 42 locations
Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases

Colorectal cancer patients with initially unresectable liver-only metastases may be cured after downsizing of metastases by neoadjuvant systemic therapy. However, the optimal neoadjuvant

primary tumor
folfiri regimen
liver surgery
folfox regimen
metastasis
  • 177 views
  • 23 Jan, 2021
  • 64 locations
POSNOC - A Trial Looking at Axillary Treatment in Early Breast Cancer

: Participants will be followed up for 5 years. Adjuvant Therapy: All participants will receive adjuvant systemic therapy (chemotherapy and/or endocrine therapy). All participants may receive breast/chest

immunostimulant
sentinel node
HER2
estrogen receptor
estrogen
  • 1778 views
  • 24 Jan, 2021
  • 50 locations
OPTimizing Irradiation Through Molecular Assesment of Lymph Node After Primary Systemic Treatment

Breast cancer management integrating surgery, systemic therapy and radiation therapy tends to systemic treatment as the first therapeutic option, continuing afterwards by surgery and radiation

core needle biopsy
female breast cancer
invasive breast cancer
carcinoma
sentinel node
  • 0 views
  • 23 Jan, 2021
  • 22 locations
Maintenance Chemotherapy With or Without Local Consolidative Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer

This randomized phase II/III trial studies how well giving maintenance chemotherapy with or without local consolidation therapy works in treating patients with stage IV non-small cell lung cancer. Drugs used in maintenance chemotherapy, such as docetaxel, pemetrexed disodium, erlotinib hydrochloride, and gemcitabine work in different ways to stop the growth …

systemic therapy
docetaxel
brain metastases
gemcitabine
tumor cells
  • 238 views
  • 03 Mar, 2021
  • 184 locations
Phase 1/2 Study of the Highly-selective RET Inhibitor Pralsetinib (BLU-667) in Patients With Thyroid Cancer Non-Small Cell Lung Cancer and Other Advanced Solid Tumors

This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in patients with medullary thyroid cancer, RET-altered NSCLC and other RET-altered solid tumors.

lung carcinoma
platinum-based chemotherapy
systemic therapy
primary cancer
nucleic acid
  • 1632 views
  • 25 Jan, 2021
  • 93 locations
A Phase 2 Study Comparing 2 Intermittent Dosing Schedules of Duvelisib in Subjects With Indolent Non-Hodgkin Lymphoma. (TEMPO)

This study will examine the effects of predefined 2 week duvelisib dose holidays on tumor responses and safety/tolerability.

  • 1 views
  • 26 Jan, 2021
  • 42 locations
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Using PET/CT Imaging

This phase III trial compares the addition of apalutamide, with or without targeted radiation therapy, to standard of care treatment versus standard of care treatment alone in patients with prostate cancer biochemical recurrence (a rise in the blood level of prostate-specific antigen [PSA] after treatment with surgery or radiation). Diagnostic …

androgens
ct scan
leuprolide
tumor cells
bone scan
  • 0 views
  • 27 Jan, 2021
  • 1 location
Dose-Reduced Consolidation Radiation Therapy in Patients With Diffuse Large B-cell Lymphoma

This phase II study will evaluate whether a reduction in radiation dose and field size will maintain a high rate of local control while minimizing the risk of acute and late toxicity . Hypothesis: The radiation dose and treatment volume can be safely reduced from 30 Gy to 20 Gy …

chemoimmunotherapy
platelet count
b-cell lymphoma
ct scan
high grade b-cell lymphoma
  • 8 views
  • 24 Jan, 2021
  • 8 locations
A Study of Apalutamide in Participants With High-Risk Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy

The purpose of this study is to determine if treatment with apalutamide plus androgen deprivation therapy (ADT) before and after radical prostatectomy with pelvic lymph node dissection (RPLND) in participants with high-risk localized or locally advanced prostate cancer results in an improvement in pathological complete response (pCR) rate and metastasis-free …

androgens
adenocarcinoma
adenocarcinoma of prostate
antiandrogen therapy
metastasis
  • 291 views
  • 15 Feb, 2021
  • 351 locations