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Found 10 clinical trials
A Study to Evaluate Organ Level Uptake Repeatability of 124I AT-01 in Subjects With Systemic Amyloidosis (AT01-001)

subjects with amyloid light chain (AL) or amyloid transthyretin (ATTR) systemic amyloidosis.

amyloid deposition
systemic amyloidosis
MRI
nt-probnp
  • 0 views
  • 21 Mar, 2022
  • 1 location
Propylene Glycol-Free Melphalan Hydrochloride (Evomela) in AL Amyloidosis Patients

This is a single arm, open label study designed to evaluate the safety and efficacy of propylene glycol-free melphalan hydrochloride in patients with AL amyloidosis. Treatment will be comprised of propylene glycol-free melphalan hydrochloride administered intravenously at a dose of 70-100 mg/m2/day on Days -3 and -2 as conditioning prior …

  • 2 views
  • 24 Mar, 2022
  • 1 location
A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis

treatment and Arm B: daratumumab + deferred VCd) in newly diagnosed systemic amyloid light chain (AL) amyloidosis with cardiac involvement and to identify potential mitigation strategies for cardiac

  • 0 views
  • 03 May, 2022
  • 1 location
Carpal Tunnel Syndrome and Amyloidosis (AMICAR)

Carpal tunnel syndrome has been suggested to be an early sign of amyloidosi. The investigators will evaluate tissue samples obtained from patients undergoing carpal tunnel release surgery for amyloid.

amyloid
amyloid deposition
carpal tunnel release
  • 13 views
  • 25 Feb, 2022
  • 1 location
Single-dose Anti-CD20 Antibody With Bortezomib for Relapsed Refractory Autoimmune Hemolytic Anemia

Patients of relapsed and refractory warm autoimmune hemolytic anemia or EVANS syndrome aged 18 to 80 will be included in this study. The treatment regimen is a single dose anti-CD20 antibody (500mg) combined with bortezomib (1.3mg/m2 twice a week for two weeks). The treatment course would be repeated three months …

treatment regimen
prednisone
  • 8 views
  • 21 Oct, 2021
  • 1 location
Molecular Imaging of Primary Amyloid Cardiomyopathy (MICA)

Cardiac amyloidosis is a major cause of early treatment-related death and poor overall survival in individuals with systemic light chain amyloidosis. This project will develop a novel approach to visualize cardiac amyloid deposits using advanced imaging methods. The long-term goal of this work is to identify the mechanisms of cardiac …

b-type natriuretic peptide
MRI
cardiac amyloidosis
immunohistochemistry
remission
  • 28 views
  • 23 Feb, 2022
  • 1 location
Characterization of Diseases With Salivary Gland Involvement

Background Salivary glands in and around the mouth and throat make saliva. Salivary gland disorders can affect a person s quality of life. Studying people who have a disease that affects their salivary gland(s) may teach researchers about the disorders and their genetics. Objectives To study salivary gland diseases and …

cancer treatment
dry eyes
Accepts healthy volunteers
cancer
  • 732 views
  • 15 May, 2022
  • 1 location
The Diagnostic Value of Hybrid PET/MR for Systemic Amyloidosis

Systemic amyloidosis is a multi-system disease caused by extracellular deposition of insoluble amyloid fibrils in various tissues and organs, leading to progressive organ dysfunction. The

  • 0 views
  • 13 May, 2022
  • 1 location
Study of Cerebral MRI Anomalies in Mutated Transthyretin Amyloidosis Patients (TTR-SNC)

angiopathy (intraparenchymal or subarachnoid hematomas, small infarcts, hemosiderin). A small number of mutations in the TTR gene cause a rare phenotype of systemic amyloidosis, the oculoleptomeningeal form

  • 0 views
  • 25 Mar, 2022
  • 1 location
Increasing Amyloidosis Awareness and Diagnosis Through Programmatic Imaging, Blood/Urine Testing and Pathology

To set up a Brazilian strategy for early diagnosis of cardiac amyloidosis using new modality of echocardiography, the 3D echocardiography, and the level of myocardial deformity by measuring the Strain Longitudinal through the technology Speckle Tracking.

cardiac amyloidosis
  • 0 views
  • 05 Jan, 2022
  • 1 location