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Found 15 clinical trials
A Clinical Study of the Efficacy of Idebenone in the Treatment of iRBD Into Synucleinopathies

142 cases of patients with iRBD will be recruited from the neurology department of Ruijin Hospital, th second Affiliated Hospital of Soochow University and wuhan Union Hospital. After the informed consent was signed, they were divided into a trial group and a control group randomly. Each group contains 71 cases. …

  • 0 views
  • 10 May, 2022
  • 1 location
The Effect of Gluten-free Diet on Parkinsonism (GFREEPARK)

Recent data suggest that the brain-gut axis, chronic intestinal inflammation and microbiome may contribute to the pathogenesis of neurodegenerative diseases with alfa-synucleinopathy, which

motor symptoms
parkinson's disease
parkinsonism
synucleinopathy
  • 0 views
  • 26 Apr, 2022
[18F]F-DOPA Imaging in Patients With Autonomic Failure

thought (a) to be restricted to the peripheral autonomic system, and (b) a clinical risk factor for the development of a central synucleinopathy, and (c) an ideal model to assess biomarkers that predict

demented
lewy body dementia
nervous system disorder
pure autonomic failure
synucleinopathy
  • 19 views
  • 01 May, 2022
  • 1 location
Intensive Multidisciplinary Rehabilitation and Biomarkers in Parkinson's Disease

Parkinson's disease (PD) is a progressive neurological disorder characterized by motor and non-motor symptoms such as rigidity, bradykinesia, resting tremor, cognitive and autonomic dysfunctions, gait and balance difficulties. The impairment of gait, balance and cognitive performances is partially responsive to dopaminergic medications. This emphasizes the importance of non-pharmacological interventions for …

bradykinesia
parkinson's disease
dopamine
tremor
motor symptoms
  • 0 views
  • 23 Jul, 2022
  • 1 location
K0706 for Patients Diagnosed With Dementia With Lewy Bodies

This study evaluates the safety and tolerability of treatment with K0706 in Dementia with Lewy Bodies (DLB). The hypothesis is that K0706 will be safe and tolerable and that this drug will alter CSF and plasma biomarkers in DLB. Clinical assessments of cognitive, behavioral and motor functioning will also be …

visual hallucinations
mental disorders
levodopa
acetylcholinesterase inhibitor
dopamine
  • 267 views
  • 13 Feb, 2022
  • 1 location
Prodromal Markers in Recurrent Dream Enactment Behaviors Without REM Sleep Without Atonia

, with a male predominance and typical onset age at early 60's. The majority of patients with idiopathic RBD (iRBD) will eventually develop α-synucleinopathy, for instance Parkinson's disease (PD). Thus

Accepts healthy volunteers
  • 0 views
  • 05 Jun, 2022
  • 1 location
PREdictive Risk Factors of Conversion Into Idiopathic RBD. Italian Study (FARPRESTO)

. To date, however, there is no reliable pool of biomarkers that predict the phenoconversion into α-synucleinopathy, the timing in which this can occur, and the phenotype of α-synucleinopathy

  • 0 views
  • 12 Mar, 2022
  • 1 location
Gut Microbiota in Major Depressive Disorders With and Without Rapid Eye Movement Behavior Disorder

The purpose of this study is to identify the variations in gut microbiota compositions between two subtypes of major depressive disorder.

Accepts healthy volunteers
  • 0 views
  • 01 Jan, 2022
  • 1 location
Familial Aggregation and Biomarkers in REM Sleep Behaviour Disorder.

In this cohort study, the investigators aim to study the familial aggregation of REM sleep behavior disorder (RBD) and compare the differences in major biomarkers of neurodegeneration, including percentage of EMG activity during REM sleep, cognitive functions, autonomic dysfunction, and psychiatric disorders, between unaffected first degree relatives of RBD cases …

neurodegeneration
psychiatric disorder
Accepts healthy volunteers
  • 7 views
  • 13 Feb, 2022
  • 1 location
Gut Microbiota in the Progression of Alpha-synucleinopathies

The aim of this study is to correlate baseline gut microbiota features and the progression of neurodegeneration in the established cohort of patients with early Parkinson's disease.

  • 0 views
  • 02 Jun, 2022
  • 1 location