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Found 12 clinical trials
An Open-label Multicenter Study to Evaluate the Efficacy and Safety of Transitioning to Lemborexant in Japanese Subjects With Insomnia

> Transition from Following 4 regimens of interest will be investigated; Z-Drug monotherapy, suvorexant (SUV) monotherapy, SUV and benzodiazepine receptor agonists (BZRA) combination therapy, and ramelteon

lemborexant
ramelteon
suvorexant
  • 0 views
  • 16 Oct, 2021
  • 9 locations
Suvorexant and Sleep/Delirium in ICU Patients

Investigators will evaluate the efficacy of postoperative oral suvorexant treatment on nighttime wakefulness after persistent sleep onset (WASO) among adult cardiac surgical patients recovering

delirium
suvorexant
coronary artery bypass
total sleep time
suvorexant 20 mg
  • 5 views
  • 04 Jun, 2022
  • 1 location
Suvorexant as an Adjunct to Buprenorphine in Persons Who Use Fentanyl

This is a 4-week, randomized-controlled trial of suvorexant vs placebo in persons with opioid use disorder who have recent fentanyl exposure. Participants will first undergo a 5-day residential

  • 0 views
  • 08 Jul, 2022
  • 1 location
Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Posttraumatic Stress

neuropeptide system underlies both sleep and stress reactivity. Suvorexant, a drug that reduces orexin, improves sleep in civilians, but has not yet been tested in Veterans with PTSD. This study will test

post-traumatic stress disorder
suvorexant
insomnia
norepinephrine
venlafaxine
  • 132 views
  • 27 Feb, 2022
  • 2 locations
Impact of Suvorexant on Sympathetic Nerve Activity and Baroreflex Function in Chronic Insomnia

This study aims to evaluate the effect of Suvorexant on sympathetic nerve activity and baroreflex function in subject with chronic insomnia. The investigator's central hypothesis is that

chronic insomnia
suvorexant
body mass index
  • 67 views
  • 04 Feb, 2022
  • 1 location
Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia

The investigators aim to determine the effect of suvorexant on actigraphically-derived total sleep time in patients with effectively treated restless legs syndrome with persistent insomnia in a

chronic insomnia
suvorexant
restless legs syndrome
total sleep time
insomnia
  • 20 views
  • 09 Sep, 2021
  • 1 location
A Single-Dose, Double-Blind, Placebo-Controlled, Randomized, Crossover Study to Determine the Abuse Potential of Single Oral Dose of Seltorexant Compared To Suvorexant and Zolpidem

The purpose of this study is to evaluate the abuse potential of seltorexant compared to placebo and two active comparators (zolpidem and suvorexant) in non-dependent, recreational sedative users

Accepts healthy volunteers
  • 0 views
  • 25 Oct, 2022
  • 1 location
Dual-Orexin Antagonism as a Mechanism for Improving Sleep and Drug Abstinence in Opioid Use Disorder

Summary of Study Protocol. This project is designed to test neurobehavioral mechanisms underlying effects of the dual orexin-1/2 receptor antagonist suvorexant on sleep efficiency and opioid

  • 0 views
  • 22 Sep, 2021
  • 1 location
Sleep Trial to Prevent Alzheimer's Disease (SToP-AD)

The purpose of this study is to determine if treatment with the sleep aid suvorexant can decrease the rate of amyloid-β (Aβ) accumulation in the brain.

dementia
amyloid
Accepts healthy volunteers
alzheimer's disease
  • 1 views
  • 04 Oct, 2022
  • 1 location
Treatment of Disturbed Sleep in Progressive Supranuclear Palsy (PSP)

: suvorexant- which targets a wake promoting system, zolpidem- a standard hypnotic that engages sleep promoting systems, versus placebo. Each condition will last 1 week and will be separated by a 1 week

  • 24 views
  • 10 May, 2022
  • 1 location