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Found 12 clinical trials
Suvorexant and Cocaine

The research proposed here will translate findings from preclinical research and provide the initial clinical evidence that orexin antagonism reduces motivation for cocaine, as well as other cocaine-associated maladaptive behaviors in active cocaine users. This study will also provide basic science information about the orexinergic mechanisms underlying the pharmacodynamic effects …

  • 4 views
  • 13 Dec, 2020
  • 1 location
Impact of Suvorexant on Sympathetic Nerve Activity and Baroreflex Function in Chronic Insomnia

This study aims to evaluate the effect of Suvorexant on sympathetic nerve activity and baroreflex function in subject with chronic insomnia. The investigator's central hypothesis is that

suvorexant
body mass index
chronic insomnia
  • 67 views
  • 04 Nov, 2020
  • 3 locations
Efficacy and Safety of Suvorexant (MK-4305) for Reducing Incidence of Delirium in Japanese Participants at High Risk of Delirium (MK-4305-085)

The goal of this study is to evaluate the efficacy and safety of suvorexant (MK-4305) for reducing the incidence of delirium in Japanese participants who are at high risk of delirium. The

  • 0 views
  • 14 Jan, 2021
  • 12 locations
Suvorexant and Trauma Related Insomnia

are limited for addressing insomnia and many insomnia treatments appear to be limited in the context of PTSD. Suvorexant is FDA approved for insomnia and among approved drugs has a unique mechanism of

suvorexant
insomnia
post-traumatic stress disorder
polysomnography
  • 0 views
  • 08 Nov, 2020
  • 1 location
Suvorexant and Sleep/Delirium in ICU Patients

Investigators will evaluate the efficacy of postoperative oral suvorexant treatment on nighttime wakefulness after persistent sleep onset (WASO) among adult cardiac surgical patients recovering

coronary artery bypass
total sleep time
suvorexant
wake after sleep onset
electroencephalogram
  • 1 views
  • 29 Jun, 2020
Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Posttraumatic Stress

neuropeptide system underlies both sleep and stress reactivity. Suvorexant, a drug that reduces orexin, improves sleep in civilians, but has not yet been tested in Veterans with PTSD. This study will test

suvorexant
fluoxetine
psychotherapy
insomnia
poor sleep
  • 29 views
  • 17 Jan, 2021
  • 2 locations
Suvorexant and Sleep's Benefits to Therapeutic Exposure for Posttraumatic Stress Disorder

The purpose of this study is to examine effects of blocking the orexin system with suvorexant after exposure-based intervention for posttraumatic stress disorder (PTSD) on sleep, PTSD symptoms

insomnia
  • 158 views
  • 29 Nov, 2020
  • 1 location
Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes

The investigators aim to determine the effect of suvorexant on subjective total sleep time (TST) in suboptimally controlled Type 2 diabetics with chronic insomnia in a randomized placebo

total sleep time
suvorexant
diabetes
wake after sleep onset
sleep disturbances
  • 48 views
  • 10 Sep, 2020
Treatment of Disturbed Sleep in Progressive Supranuclear Palsy (PSP)

: suvorexant- which targets a wake promoting system, zolpidem- a standard hypnotic that engages sleep promoting systems, versus placebo. Each condition will last 1 week and will be separated by a 1 week

  • 20 views
  • 26 Aug, 2020
  • 1 location
Examining the Role of the Orexin System in Sleep and Stress in Persons With Opioid Use Disorder

-release naltrexone (XR-NTX) or methadone. Within the XR-NTX (n=100) and methadone (n=100) groups, participants will be randomized to either suvorexant (n=50 in each MAT) or placebo (n=50 in each MAT). The

  • 0 views
  • 02 Dec, 2020
  • 4 locations