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Found 51 clinical trials
Preoperative Preparation With Lugol Solution in Patients With Graves-Basedow Disease. (LIGRADIS)

variables Surgical time. Antibiotic prophylaxis Intraoperative hemorrhage. Thyroidectomy Difficulty Scale. Loss of electromyographic signal during neural

eye disease
body mass index
  • 28 Feb, 2022
  • 19 locations
Perioperative Management in Gynaecological Carcinoma Surgery

This study is to determine the effect of perioperative treatment with intravenous iron and tranexamic acid on the reduction of intraoperative and postoperative RBC transfusions in gynaecological carcinoma patients undergoing abdominal surgery.

  • 04 Oct, 2022
  • 1 location
Postoperative Replacement of Intraoperative Iron Losses (POREIIL)

By performing a randomized, blinded placebo controlled exploratory trial we speculate that replacement of perioperative, bleeding-induced iron losses with ferric carboxymaltose immediately after the surgical procedure can replenish iron with increased hemoglobin levels and reduce the amount of pRBCs transfused in the postoperative period (30 days post surgery).

  • 19 Apr, 2022
  • 1 location
Minimally Invasive Versus Open Radical Pancreatectomy After Neoadjuvant Chemotherapy for Pancreatic Cancer

The aim of this study is to evaluate the safety and effectiveness of minimally invasive versus open radical pancreatectomy after neoadjuvant chemotherapy for pancreatic ductal adenocarcinoma

  • 18 Sep, 2021
The Cryopreserved vs. Liquid Platelets Trial (CLIP II)

This trial is a phase III multicentre blinded randomised controlled clinical non-inferiority trial of cryopreserved platelets vs. conventional liquid-stored platelets for the management of surgical bleeding. The aim of the study is to assess the efficacy, safety and cost effectiveness of cryopreserved platelets, compared to conventional liquid-stored platelets, for the …

  • 04 Oct, 2022
  • 6 locations
DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery (DEPOSITION)

The aim is to conduct a double-dummy multi-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TxA) versus the usual intravenous TxA in patients undergoing on-pump cardiac surgery.

postoperative hemorrhage
coronary artery bypass graft
tranexamic acid
postoperative bleeding
  • 04 Oct, 2022
  • 7 locations
Preoperative Oral Antibiotics With vs Without Mechanical Bowel Preparation to Reduce Surgical Site Infections Following Colonic Resection: an International Randomized Controlled Trial. (ORALEV2)

The ORALEV Study found that preoperative oral antibiotics can reduce the incidence of surgical site infections after colonic resection, compared with no preparation. The role of mechanical bowel preparation in patients needing colonic surgery is yet to be elucidated. No randomised controlled trials have assessed the impact of mechanical bowel …

elective surgery
  • 10 May, 2022
  • 8 locations
Pre-operative Enoxaparin in the Surgical Management of Multi-trauma Patients Undergoing Orthopedic Surgical Procedures

All trauma patients receive Lovenox or other prophylactic medication to prevent deep vein clots from forming. For the trauma patients with orthopedic injuries requiring surgery there is controversy over safety and efficacy when prophylaxis is started preoperatively vs postoperatively. This study is to evaluate both approaches for safety in terms …

  • 21 Mar, 2022
  • 1 location
Comparison Between Hyperoncotic and Isooncotic Albumin to Support Blood Loss Replacement (VASCALB)

Fluid intravascular replacement is usually performed with either balanced crystalloids or iso-oncotic colloids, (synthetic colloids, plasma and 5% albumin). Doubts have been raised about synthetic colloids, and albumin solutions have been used more extensively. Albumin is the main protein responsible for plasma oncotic pressure and its volume expansion effect. The …

  • 09 Jun, 2022
  • 1 location
Tranexamic Acid in Adult Spinal Deformity Surgery

Posterior spinal surgery for adult deformity is associated with high incidence of blood loss and need for blood transfusion and intraoperative blood salvage, with associated increased cost and risk for perioperative complications. Tranexamic acid (TXA) is relatively inexpensive anti-fibrinolytic agent that has been proven effective for decreasing intraoperative blood loss …

blood transfusion
intraoperative blood loss
fibrinolytic agent
heart surgery
  • 04 Oct, 2022
  • 1 location