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Found 40 clinical trials
Featured trial
Peripheral Tissue Biomarker for Diagnosis of Lewy Body Dementia and Alzheimer's Disease

The purpose of this study is to identify changes on a skin punch biopsy or olfactory mucosa (tissue in the back of the nose) sampling, in which small pieces of skin are removed or a swab or brush is placed in the back of the nose, and then tissue is …

parkinson's disease
mild cognitive impairment
dementia
neurodegenerative diseases
corticobasal degeneration
  • 0 views
  • 25 Jan, 2023
  • 1 location
Featured trial
New Approaches to Dementia Heterogeneity.

This study is looking for adults who have mild cognitive impairment, Alzheimer’s, or other forms of dementia. The study is also looking for people with normal cognition, as a comparison. The study is interested in the ways that brain function changes over time with the goal of improving the ability to diagnose …

mild cognitive impairment
dementia
cognitive impairment
aphasia
heart disease
  • 160 views
  • 25 May, 2021
  • 1 location
Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of NIO752 in Progressive Supranuclear Palsy

This is a phase 1, multi-center, double-blind, placebo-controlled, multiple dose escalation study with NIO752 in progressive supranuclear palsy (PSP) participants.

levodopa
dopamine
rasagiline
coenzyme q
carbidopa
  • 24 views
  • 10 Mar, 2022
  • 11 locations
Epidemiology and Pathophysiology of Parkinsonism in the Caribbeans

The primary aim of this study is to estimate the frequency and to characterize clinically atypical parkinsonism in the French West Indies and Guyana.

  • 0 views
  • 21 Jan, 2021
  • 2 locations
A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy

This study is designed to learn more about overall tau burden in the brain of patients with Progressive Supranuclear Palsy (PSP).

cognitive assessment
Accepts healthy volunteers
  • 124 views
  • 25 Jan, 2022
  • 1 location
Spinal Cord Stimulation Therapy for Freezing of Gait in Parkinson's Syndrome Patients

Spinal cord stimulation may be a new therapeutic approach for freezing of gait. It's a multi-center, prospective, open label clinical study with a 12 months follow-up period, to investigate the therapeutic effect and safety of spinal cord stimulation for freezing of gait in patients with advanced Parkinson's disease and Parkinsonism-Plus …

  • 0 views
  • 28 Jan, 2021
  • 1 location
Trial of Parkinson's And Zoledronic Acid (TOPAZ)

This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will …

parkinsonism
parkinson's disease
dementia
zoledronic acid
cognitive assessment
  • 256 views
  • 12 May, 2022
  • 53 locations
Community Outreach for Palliative Engagement -- Parkinson Disease (COPE-PD)

The purpose of this study is to learn more about the effectiveness of palliative care training for community physicians and telemedicine support services for patients and carepartners with Parkinson's disease and Lewy Body Dementia (LBD) or related conditions and their care partners. Palliative care is a treatment approach focused on …

parkinsonism
parkinson's disease
dementia
depression
supranuclear palsy
  • 3 views
  • 10 May, 2022
  • 1 location
The Swedish BioFINDER 2 Study (BioFINDER2)

The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study (www.biofinder.se). BioFINDER 1 is used e.g. to characterize the role of beta-amyloid pathology in early diagnosis of Alzheimer's disease (AD) using amyloid-PET (18F-Flutemetamol) and A analysis in …

amyloid
parkinson's disease
mini-mental state examination
mild cognitive impairment
cognitive impairment
  • 178 views
  • 25 Feb, 2022
  • 1 location
Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy

The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP). The central hypothesis is that augmenting cerebellar inhibition via cerebellar rTMS will decrease postural instability in patients with PSP by increasing functional connectivity between the …

screening procedures
dopamine
  • 42 views
  • 30 May, 2022
  • 1 location