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Found 10 clinical trials
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Pilot Study of the Safety and Efficacy of Sulfasalazine in Pulmonary Arterial Hypertension

Under placebo control, the investigators intend to evaluate the effectiveness and safety of anti-inflammatory therapy and/or targeted drug therapy for early treatment of patients with pulmonary arterial hypertension.

digoxin
ambrisentan
hypertension
diuretics
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
The Role of Tofacitinib in Steroid Withdrawal in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a systemic chronic arthritis characterized by systemic inflammation, persistent synovitis and final joint destruction Inflammatory diseases can lead to decreased productivity and impaired health-related quality of life. As a chronic disease, rheumatoid Chronic arthritis needs long-term treatment. At the same time, RA can cause skin, eye, …

DMARD
antirheumatics
stiffness
synovitis
tofacitinib
  • 0 views
  • 22 Jun, 2021
  • 1 location
None
Study to Demonstrate the Efficacy Safety and Tolerability of an Intravenous Regimen of Secukinumab Compared to Placebo in Subjects With Active axSpA

The purpose of this global study is to demonstrate the efficacy, safety, and tolerability of an intravenous (i.v.) regimen of secukinumab compared to placebo in subjects with active axSpA at Week 16 despite current or previous NSAID, DMARD and/or anti Tumor Necrosis Factor (TNF) therapy. In addition, to further support …

  • 85 views
  • 27 Aug, 2021
  • 110 locations
None
Optimal Nutrition for Prevention of Hypertension in Pregnancy

The aim of this study is to investigate the role of the 677CT polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene on blood pressure (BP) during pregnancy, and to examine the effect of intervention with riboflavin, alone or in combination with 5-methyltetrahydrofolate (5-MTHF), as a non-drug approach for managing BP in …

  • 0 views
  • 28 Jan, 2021
  • 3 locations
None
Sulfasalazine and Stereotactic Radiosurgery for Recurrent Glioblastoma

This study evaluates the safety associated with the addition of sulfasalazine to stereotactic radiosurgery for recurrent glioblastoma. Sulfasalazine is a potential tumor selective

karnofsky performance status
glioblastoma multiforme
radiosensitizer
temozolomide
international normalized ratio
  • 3 views
  • 04 Sep, 2021
  • 1 location
None
Sulfasalazine in Decreasing Opioids Requirements in Breast Cancer Patients

lowering the doses of opioids needed and lowering side effects. Sulfasalazine poses such quality it is a safe anti-inflammatory drug with established safety profile. It has been in use for over 50 years

  • 0 views
  • 28 Jul, 2021
  • 2 locations
None
Enbrel-Sulfasalazin-Early-Axial Spondyloarthritis (AS)

Efficacy - To assess efficacy of etanercept versus sulfasalazine when added to NSAIDs in patients with moderate to severe active early axial spondyloarthritis duration of ongoing axial

  • 12 views
  • 07 Nov, 2020
  • 6 locations
None
Severe Psoriatic Arthritis - Early intervEntion to Control Disease: the SPEED Trial

SPEED is a three arm interventional trial nested within a cohort (Trials Within Cohorts or TWiCs design). This tests more aggressive early therapy in patients newly diagnosed with moderate to severe PsA. Arm 1 will receive standard step up therapy in the cohort and act as the control group. Arm …

tumor necrosis factor
methotrexate
anti-rheumatic drugs
sulfasalazine
leflunomide
  • 2 views
  • 05 May, 2021
  • 1 location
None
Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease PRD) Refractory to Standard Therapy

Patients receiving radiation therapy are still at risk for side effects due to off-target radiation damage of normal tissues The number of cancer patients is expected to increase from 14.1 million around the world in 2012 to 19.3 million in 2025. Up to ten percent will develop late severe gastrointestinal …

  • 0 views
  • 11 Aug, 2021
  • 2 locations
None
Molecular Effects of Apremilast in the Synovium of Psoriatic Arthritis Patients

This study assess the genomics profiles in synovial biopsies obtained prior to, and 24 weeks after an immunomodulator agent (Apremilast) in patients with active psoriatic arthritis who are naive to treatment with a conventional synthetic DMARDs (such as methotrexate).

  • 0 views
  • 27 Jan, 2021
  • 1 location