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Found 41 clinical trials
Pioglitazone for the Treatment of Alcohol Use Disorder (PAUSE)

Alcohol Use Disorder (AUD) is common among Veterans but medication treatment is used infrequently and the impact of these treatments are small to moderate at best. Pioglitazone, a medication FDA approved for diabetes, has been shown in pre-clinical studies to reduce alcohol. The proposed study will test the efficacy of …

diabetes
antidepressants
scid
heavy drinking
  • 29 views
  • 01 May, 2022
  • 2 locations
Optimal Treatment of Veterans With PTSD and Comorbid OUD

The objective of this study is to test a standard psychotherapy for PTSD in Veterans who also suffer from Opiate Use Disorder (OUD). Specifically, this study will test whether Cognitive Processing Therapy (CPT)-C is more effective in treating PTSD, compared to a control group (Individual Drug Counseling (IDC); which approximates …

scid
opioid
psychotherapy
opiates
cognitive therapy
  • 15 views
  • 02 May, 2022
  • 2 locations
Siltuximab in Schizophrenia

This study is a Phase 1 clinical trial to determine the safety, tolerability, and efficacy of Siltuximab (Sylvant) as an adjunct to antipsychotic medications in stable outpatients with schizophrenia. Siltuximab (structural formula C6450H9932N1688O2016S50) is a recombinant chimeric (human-murine) anti-human interleukin-6 (IL-6) monoclonal antibody. Siltuximab is formulated as a concentrate for …

schizoaffective disorder
schizophrenia
adjunctive treatment
cancer
clozapine
  • 93 views
  • 23 Feb, 2022
  • 1 location
Integrated Care in Psychotic Disorders With Severe Mental Illness

The study examine the effectiveness of an integrated care program including therapeutic assertive community treatment (ACT) for people with psychotic disorders fulfilling severe and persistent mental illness (SPMI, ACCESS-II study).

delusions
psychiatric disorder
major depressive disorder
hallucinations
psychosis
  • 100 views
  • 06 Oct, 2021
  • 1 location
Efficacy Study of a New Individualized Rehabilitation Programme for Social Cognition in Patients With Schizophrenia

Patients affected by schizophrenia often present significant deficits in various aspects of social cognition, such as social perception, recognition of one's own and other people's emotional state and the theory of mind. Recent studies investigated the correlation between social cognition and real-life functioning, reporting that greater social cognition deficits determine …

schizoaffective disorder
schizophrenia
psychiatric treatment
cognitive remediation
  • 0 views
  • 18 Dec, 2021
  • 1 location
Scopolamine in Bipolar Depression

This is a single-site, randomised, double-blind, placebo-controlled, parallel, phase IIb clinical trial. The primary objective of the SCOPE-BD study is to investigate the efficacy and safety of IV Scopolamine, compared to placebo, in reducing severity of depression in individuals with bipolar disorder who are experiencing a depressive episode of at …

  • 0 views
  • 16 May, 2021
  • 1 location
Diagnostic Tools for Identifying Prolonged Grief

Development and validation of first clinical diagnostic interview for assessing Prolonged Grief Disorder (PGD) with the ICD 11 and DSM 5 Tr criteria.

  • 0 views
  • 23 May, 2022
  • 1 location
Opioid/Benzodiazepine Polydrug Abuse

Benzodiazepine (BZD)/opioid polysubstance abuse (PSA) dramatically increases risks of overdose, disability and death; however, little is known about phenotypes that could be targeted to decrease this use and these associated risks. The opioid abuse epidemic is generating unprecedented numbers of overdoses (OD) and deaths from prescribed and illegal sources (e.g. …

  • 20 views
  • 10 May, 2022
  • 1 location
The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Registry

While effective interventions for depression exist, their success rates are unsatisfactory and their provision is haphazard. The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Depression Hub will improve the delivery of care and the quality of outcomes for youths, adults and seniors with depression across the Maritimes. The investigators …

depression
psychiatric disorder
depressed mood
  • 833 views
  • 23 Jan, 2021
  • 1 location
Survey on Patients After Childbearth Following Bariatric Surgery (SPOtMom)

Women with a history of bariatric surgery may face various difficulties during pregnancy and puerperal time. Therefore it is assumed the prevalence of mental health disorders might be higher than in average women during and after pregnancy. This could possibly lead to an unsatisfying weight progress and therapeutic non-adherence. These …

  • 1 views
  • 21 Mar, 2022
  • 1 location