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Found 41 clinical trials
Randomized Controlled Trial of Pyridoxine for Tardive Dyskinesia

Purpose: Tardive dyskinesia (TD) is a involuntary movement disorder that can occur following long term treatment with antipsychotic medications and for which few treatment options exist. This study will test the efficacy of pyridoxine (also known as vitamin B6) for TD. This will be an 8 week double-blind, placebo-controlled, randomized …

dopamine antagonist
movement disorder
dopamine
involuntary movements
schizophrenia
  • 320 views
  • 01 May, 2022
  • 1 location
Use of CBD Oil in the Treatment of Posttraumatic Stress Disorder

The overarching objective of the proposed project is to test the clinical efficacy of CBD in the treatment of post-traumatic stress disorder using a rigorous double-blind randomized clinical trial methodology. Participants (n=150) meeting full DSM-5 criteria for post-traumatic stress disorder (PTSD) will be randomized to one of 3 treatment arms: …

psychotherapy
psychiatric disorder
  • 615 views
  • 21 Feb, 2022
  • 1 location
Group Metacognitive Therapy vs Clinical Management for Depression

The main aims of the study are to (1) compare the effectiveness of Group metacognitive therapy (GMCT) treatment to that of clinical management and (2) explore patterns of change and investigate factors associated with treatment outcome

depression
  • 2 views
  • 15 Feb, 2022
  • 1 location
A Rater-blinded RCT to Compare Effectiveness of EMDR vs TAU in Patients With First Episode Psychosis and History of Psychological Trauma

The main objective of this project is to analyze whether EMDR therapy, as an adjuvant to usual treatment, is effective in reducing post-traumatic stress and psychotic/affective symptoms in patients with a FEP and comorbid psychological trauma associated with first hospital admission and / or previous stressful life event.

psychotic symptoms
acute stress disorder
eye movement desensitization and reprocessing
psychiatric hospitalization
psychosis
  • 0 views
  • 07 Apr, 2022
  • 1 location
Role of Slow-wave Activity and Plasticity in MDD

The hypothesis underlying this proposal is that deficits of synaptic plasticity underlie the slow-wave activity (SWA) abnormalities observed n major depressive disorder (MDD), and that manipulating SWA may serve to circumvent these deficits by facilitating an increase in synaptic strength via the inhibition of synaptic down-scaling, thereby improving plasticity and …

major depressive disorder
scid
depressive disorder
depressed mood
  • 57 views
  • 06 Aug, 2021
  • 1 location
Suvorexant in the Management Comorbid Sleep Disorder and Alcohol Dependence

Suvorexant (trade name Belsomra) is an orexin receptor antagonist that has TGA approval for the treatment of insomnia, characterised by difficulties with sleep onset and/or sleep maintenance. It may also have a role in addictions as the orexins play a critical role in drug addiction and reward-related behaviours. Orexins appear …

sleep disorder
suvorexant
  • 0 views
  • 27 Aug, 2021
  • 1 location
Comparing Group Therapies for Veterans With Depression and PTSD

Cognitive behavioral therapy (CBT) is a brief, efficient, and effective psychotherapy for individuals with depressive and PTSD. However, CBT is largely underutilized within Veteran Affairs Medical Centers (VAMCs) due to the cost and burden of trainings necessary to deliver the large number of CBT protocols. Transdiagnostic Behavior Therapy (TBT), in …

psychotherapy
depression
behavior therapy
  • 0 views
  • 23 Mar, 2022
  • 1 location
Feasibility Trial of Tele-IPT and Tele-Pharmacotherapy for Patients With Depression and Non-Metastatic Breast Cancer (IPT)

Cancer and depression commonly occur together, and each worsens the other. We conducted a large psychotherapy study treating depression in breast cancer patients, showing that psychotherapy lowers symptoms. Surprisingly, no studies have compared depression-focused psychotherapy to antidepressant medication for patients with breast cancer and depression. We applied to the National …

  • 0 views
  • 06 Apr, 2022
  • 1 location
Bulimia Nervosa and Binge Eating Disorder: Comparing Therapeutic Strategies

This study aims to assess the effectiveness of new neurostimulation techniques in patients with eating disorders. The primary aim of our proposal is to test a reduction in symptoms of alteration of eating behaviors, such as always thinking about food or binge eating, in a sample of 30 patients, aged …

behavior therapy
bulimia nervosa
depression
eating disorder
5 minutes
  • 0 views
  • 29 Apr, 2022
  • 1 location
Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic Disorder

Cognitive behavioral therapy (CBT) is a brief, efficient, and effective treatment for individuals with depressive/anxiety disorders. However, CBT is largely underutilized within the Department of Veterans Affairs due to the cost and burden of trainings necessary to deliver all of the related disorder-specific treatments (DSTs). Transdiagnostic Behavior Therapy (TBT), in …

anxiety
panic disorder
behavior therapy
psychotherapy
depression
  • 0 views
  • 30 Apr, 2022
  • 1 location