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Found 41 clinical trials
Screening and Intervention Reducing Anxiety in Patients With Cardiac Disease

The hypothesis is that there is a significant difference in anxiety scores between intervention and usual care group after intervention. The aim of Heart & Mind Trial is (I) to determine the type of anxiety in cardiac patients and (ii) to investigate the effect of individual cognitive behavioural therapeutic intervention …

  • 0 views
  • 29 Dec, 2021
  • 1 location
Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders

Preclinical and clinical data as well as mechanistic justification have been presented suggesting citicoline and pregnenolone are each promising treatments for alcohol use in BPD. Both appear to have favorable side effect profiles and no known drug-drug interactions. Thus, they have the potential to be safely used in a dual …

valproate
antipsychotics
mood stabilizer
schizoaffective disorder
bipolar disorder
  • 1214 views
  • 24 Mar, 2022
  • 1 location
A Clinical Trial of a Hemp-Derived Cannabidiol Product for Anxiety

This open-label to double-blind study evaluates the impact of cannabidiol (CBD) on anxiety in adults. Participants will use a custom-formulated sublingual (under-the-tongue) solution of whole plant, hemp-derived CBD twice daily for six weeks in addition to their normal treatment regimen. Participants' clinical state will be assessed weekly during the treatment …

  • 0 views
  • 15 Apr, 2021
  • 1 location
Addressing Heavy Alcohol Use Consumption With Kudzu (A-HACK)

Drinking multiple alcoholic drinks on a single occasion (binge drinking), has many negative health risks but interventions to address this behavior remain limited. This double-blind, placebo-controlled randomized clinical trial will test whether kudzu, an herbal supplement, can reduce heavy alcohol use and alcohol-associated sexual behaviors among sexually-active, binge-drinking individuals at …

heavy drinking
scid
antibody response
Accepts healthy volunteers
drug abuse
  • 64 views
  • 19 Feb, 2022
  • 1 location
Ketogenic Diet for Psychotic Disorders

Disturbances in glucose metabolism and glutamate neurotransmission feature in the pathophysiology of psychotic disorders. Ketogenic diet (KD) is a high-fat, low-carbohydrate diet that restricts glucose and forces metabolism of ketones, which serve as alternative energy substrates for the brain. KD is an established treatment for intractable epilepsy. However, we lack …

psychotic symptoms
  • 0 views
  • 24 Sep, 2021
  • 1 location
Sublingual Cannabidiol for Anxiety

This is an open-label to double-blind study evaluating the effects of cannabidiol (CBD) for the treatment of anxiety in adults. Participants will use a sublingual (under-the-tongue) solution of whole plant-derived CBD or placebo three times daily for four weeks in addition to their normal treatment regimen. Participants' clinical state will …

treatment regimen
anxiety
cannabidiol
  • 481 views
  • 03 Mar, 2022
  • 1 location
Cognitive Behavior Therapy for Depression

Psychological mindedness(PM) is a metacognitive process in which the person uses his cognitive and affective abilities to understand his thoughts, feelings, and his behaviors as they interact with his internal experiences and his external experiences in the world. It dynamically modifies his behavior to move towards self-actualization in a manner …

behavior modification
depressed mood
major depressive disorder
benzodiazepines
depression
  • 20 views
  • 28 Dec, 2021
  • 1 location
Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression

We propose a clinical study of medial forebrain bundle DBS as a treatment in 10 patients with treatment refractory depression (TRD). Data from the University of Bonn indicates that surgical lesions of the medical forebrain bundle can produce therapeutic benefits in patients with depressive disorders, and suggest that DBS at …

suicidal
depressive disorder
psychotropic drugs
brain stimulation
antipsychotics
  • 259 views
  • 12 Mar, 2022
  • 1 location
MRI Markers of Feedback Timing During Learning in Individuals With TBI With and Without Clinical Depression

The goal of this proposal is to examine the influence of feedback timing on learning and brain function in individuals with moderate-to-severe traumatic brain injury (TBI), with and without depression.

traumatic brain injury
Accepts healthy volunteers
severe traumatic brain injury
  • 0 views
  • 03 Dec, 2021
  • 1 location
Testing the Efficacy of an Eye-tracking-based Treatment in Reducing Stress-related Symptoms in Veterans With PTSD

The study will examine the efficacy of a feedback-based treatment applying eye-tracking (Gaze-Contingent Music Reward Therapy) to change attention and gaze patterns associated with angry faces relative to a response-time-based attention bias modification treatment applying the dot-probe task and a control group.

  • 0 views
  • 21 Mar, 2022
  • 1 location