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Found 40 clinical trials
Minocycline as Adjunctive Treatment for Treatment Resistant Depression (MINDEP2)

respond to antidepressant treatment, confirmed by the Structured Clinical Interview for DSM-5 (SCID-5) and the Antidepressant Treatment History Form (ATHF) at screening. After screening and randomization

antidepressants
bupropion
duloxetine
depressive disorder
mirtazapine
  • 108 views
  • 12 May, 2022
  • 1 location
Neurofeedback to Treat Depression

This study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with MDD (60 in R61 phase and 80 in R33 Phase). This real-time fMRI neurofeedback therapy uses cloud-based pattern classification to decode a patient's attentional state and dynamically modulate …

  • 0 views
  • 22 Apr, 2022
  • 1 location
A Couples' Intervention Protocol for PTSD

Posttraumatic stress disorder (PTSD) is a multifaceted disorder resulting from intense and/or life-threatening trauma. PTSD sequelae often have a ripple effect on close others, including spouses and children. Studies report high levels of relationship distress for both those with PTSD and their partners as well as emotional distress. Despite the …

  • 0 views
  • 01 Oct, 2021
  • 1 location
Plan D- Vitamin D Supplementation in Psychotic Disorders

Background: Impairment in cognitive processing speed is a consistent finding in schizophrenia spectrum disorder. Vitamin D deficiency is found to be significantly associated with reduced processing speed. In this study, we will investigate the effect from vitamin D supplementation on processing speed. Objective: The primary objective is to investigate whether …

  • 0 views
  • 26 Apr, 2022
Prevention of OUD: The HOME Project (Housing, Opportunities, Motivation and Engagement) (HOME)

Homeless youth have a much higher rate of substance use than non-homeless peers with evidence suggesting that homeless youth have the highest rates of opioid use among youth subgroups in the country (Brands et al., 2005); heroin using homeless youth also appear to have the highest rates of IV drug …

Accepts healthy volunteers
  • 8 views
  • 17 Mar, 2022
  • 1 location
Development of a Recovery Oriented Treatment for Post-Acute Suicidal Episode (PASE) Veterans

Mental health care for Veterans with suicidal symptoms is of paramount import to the VA. Unfortunately, VA suicide reports show suicide rates increasing, suggesting a need for enhancing current VA suicide mental health care efforts. While several psychotherapeutic treatments exist for acute suicidality, there are few treatments designed to help …

  • 0 views
  • 21 Apr, 2022
  • 1 location
Blended Care Versus Face-to-Face Therapy for Depression (BLENDED)

Depression is a severe mental disorder that affects 5-7% of Belgians each year. Unfortunately, many individuals with depression do not seek professional help, and if they do seek professional help, waiting lists for psychotherapy are typically very long. To help resolve this problem, this study aims to investigate whether blended …

anxiety
behavior modification
major depressive disorder
cognitive therapy
psychotherapy
  • 0 views
  • 03 Mar, 2022
  • 5 locations
Adjunctive Vortioxetine in Schizophrenia (AVIS)

with a research diagnosis of schizophrenia determined with the Structured Clinical Interview for DSM (SCID). Patient randomization will be stratified by illness duration (i.e., </=5 years and >5

antidepressants
cognitive symptoms
benzodiazepines
psychotic symptoms
antipsychotics
  • 70 views
  • 25 Apr, 2022
  • 3 locations
The Impact of Aripiprazole Long-acting on Myelin and Cognition in the Onset of Schizophrenia

neuroprotective that could counteract the progressive neuronal degeneration inherent in the schizophrenic pathology itself. Each subject will undergo a structured clinical interview to assess the presence

psychotic episode
structured clinical interview
aripiprazole
psychotropic drugs
scid
  • 0 views
  • 01 May, 2022
  • 1 location
Screening and Intervention Reducing Anxiety in Patients With Cardiac Disease

The hypothesis is that there is a significant difference in anxiety scores between intervention and usual care group after intervention. The aim of Heart & Mind Trial is (I) to determine the type of anxiety in cardiac patients and (ii) to investigate the effect of individual cognitive behavioural therapeutic intervention …

  • 0 views
  • 29 Dec, 2021
  • 1 location