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Found 67 clinical trials
GIST and Memory and Attention Adaptation Training (GIST-MAAT)

underserved areas where cancer survivor services are less available. People with a diagnosis of gastrointestinal stromal tumors also experience self-reported cancer-related cognitive impairment. In

  • 1 views
  • 01 May, 2022
  • 1 location
Vaccine Therapy in Treating Patients With Metastatic Solid Tumors

This phase I trial studies the side effects and best dose of vaccine therapy in treating patients with metastatic solid tumors. Vaccines made from antibodies and peptides combined with tumor cells may help the body build an effective immune response to kill tumor cells.

mammogram
solid tumour
cancer
erbb2
neuropathy
  • 37 views
  • 03 Nov, 2021
  • 1 location
Nirogacestat in Ovarian Granulosa Cell Tumors

This phase 2 clinical trial will study the effectiveness of nirogacestat in ovarian granulosa cell tumors (OvGCTs). Nirogacestat is a gamma secretase inhibitor (GSI) which is hypothesized to decrease the growth and activity of ovarian granulosa tumors.

measurable disease
  • 0 views
  • 04 Oct, 2022
  • 1 location
CMP-001 and Pre-operative Stereotactic Body Radiation Therapy (SBRT) in Early Stage Triple Negative Breast Cancer (TNBC)

main hypothesis that the study treatment induces an increase in stromal tumor infiltrating lymphocytes (sTILs) will be explored in each arm separately. The study is designed as a randomized

mammogram
erbb2
breast surgery
estrogen
mastectomy
  • 0 views
  • 19 Jul, 2021
  • 1 location
FUlvestrant in Gynecological Cancers That Are Potentially Hormone Sensitive: the FUCHSia Study (FUCHSia)

In this phase 2 clinical trial, the aim is to evaluate the efficacy of the ER-antagonist Fulvestrant in women with estrogen receptor positive (ER+) low grade gynecological cancers. The primary objective of the study is to determine the response rate (RR) upon Fulvestrant treatment, comprising either partial or complete response, …

sarcoma
cancer
estrogen
carcinoma
liver metastasis
  • 24 views
  • 03 Feb, 2022
  • 1 location
Study With Atezolizumab in Combination With Trastuzumab and Vinorelbine in HER2-positive Advanced/Metastatic Breast Cancer

-like and HER2-E are associated with higher expression of immune-related genes or higher infiltration of stromal tumor infiltrating lymphocytes compared to the luminal subtypes. Immune infiltration in

  • 0 views
  • 25 Mar, 2021
  • 2 locations
A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors (REGOMUNE)

Assessment of the efficacy and safety of Regorafenib and Avelumab in patients with advanced or metastatic solid tumors (ten cohorts), once the Recommanded Phase II Dose (RP2D) has been determined (phase I trial). Assessement of the efficacy and safety of a low-dose of regorafenib (80mg/day) with avelumab in patients with …

proto-oncogene tyrosine-protein kinase ros
cancer
lung carcinoma
ROS1
BRAF
  • 44 views
  • 04 Mar, 2022
  • 6 locations
Three Versus Five Years of Adjuvant Imatinib as Treatment of Patients With Operable GIST

In this study, patients who have been diagnosed with gastrointestinal stromal tumor (GIST) and have been treated with adjuvant imatinib for 3 years after surgery will be randomly allocated in a

gleevec
KIT
gastrointestinal stromal tumor
imatinib
ct scan
  • 7 views
  • 23 Mar, 2022
  • 1 location
Regorafenib Followed by Nivolumab in Patients With Hepatocellular Carcinoma (GOING) (GOING)

, RAF-1, BRAF, BRAFV600E), metastasis (VEGFR3, PDGFR, FGFR) and tumour immunity (CSF1R). In particular, regorafenib inhibits mutated KIT, a major oncogenic driver in gastrointestinal stromal tumours

liver disease
cancer
nivolumab
RET
BRAF
  • 0 views
  • 24 May, 2022
  • 6 locations
DNX-2440 for Resectable Colorectal Liver Metastasis

The purpose of this study is to test an experimental oncolytic adenovirus called DNX-2440 in patients with resectable multifocal (≥ 2 lesions) liver metastasis, who are scheduled to have curative-intent liver resection surgery. Up to 18 patients will receive two sequential intra-tumoral injections of DNX-2440 into a metastatic liver tumor …

squamous cell carcinoma
cancer
carcinoma
gastrointestinal stromal tumor
liver metastasis
  • 0 views
  • 19 Apr, 2022
  • 1 location