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Found 84 clinical trials
The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion During Exercise in Patients With PAD

Peripheral arterial disease (PAD) is a highly prevalent and costly condition. Intermittent claudication (IC), defined as ischemic leg pain that occurs with walking, results in functional impairment, reduced daily physical activity, and a lower quality of life. Although the mechanisms contributing to functional impairment are not fully delineated, current evidence …

pain-free
intermittent claudication
critical limb ischemia
leg pain
arterial disease
  • 0 views
  • 26 Sep, 2021
  • 1 location
INvestigation of TENS Efficacy Versus Posterior Tibial Nerve Stimulation for Overactive Bladder (INTENSE)

The objective of this research is to perform a non-masked, non-inferiority randomized controlled trial to assess the quality of life (QOL) of women with idiopathic overactive bladder (OAB) before and after treatment with percutaneous tibial nerve stimulation (PTNS) or transcutaneous electrical nerve stimulation (TENS) of tibial nerve. The target population …

conservative therapy
transcutaneous electrical nerve stimulation
caffeine
percutaneous tibial nerve stimulation
incontinence
  • 0 views
  • 23 Jul, 2022
  • 1 location
Microvascular Dysfunction in Obesity

Impaired endothelial function is observed in disease states related to obesity, such as atherosclerosis, coronary artery disease, and diabetes. Reactive oxygen species (ROS) production and resultant oxidative stress contribute to the development of these obesity-related diseases. The enzyme NADPH-oxidase is a major source of oxidative stress within the vasculature, and …

Accepts healthy volunteers
diabetes
metabolic syndrome
  • 0 views
  • 30 Jun, 2022
  • 1 location
Ultra-high-resolution CT vs. Conventional Angiography for Detecting Coronary Heart Disease

Cardiac catheterization with invasive coronary angiography is the gold standard for determining the presence or absence of significant coronary heart disease (CHD). However, cardiac catheterization is costly and, as an invasive procedure, it is associated with some risk of adverse events, rarely even stroke, myocardial infarction, or death. Recent advances …

infarct
myocardial infarction
stroke
stenosis
heart disease
  • 2 views
  • 23 Jul, 2022
  • 1 location
Effort-Lung Ultra Sound

stress test on a bicycle ergometer with the diagnosis of heart failure with preserved ejection fraction (HFpEF).

  • 0 views
  • 24 Sep, 2021
  • 1 location
Diastolic Exercise Stress Testing in Heart Failure (DEST-HF)

. All patients with a resting pulmonary artery wedge pressure (PAWP) <15mmHg will undergo the following stress test modalities in a randomized order: (1) bicycle ergometry, (2) dynamic handgrip

  • 0 views
  • 27 May, 2022
Exploration of Dyspnea at Non-high Brain Natriuretic Peptide (BNP)

in < 75 years, and < 450 pg/ml in 75 years will be studied with stress echocardiography and cardiometabolic stress test (VO2). These patients may have abnormal adaptation during exercise

n-terminal pro-bnp
dyspnea
natriuretic peptide
carbon monoxide
blood test
  • 2 views
  • 23 Jan, 2021
  • 5 locations
NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)

brain, leg muscles, bone density and body mass will be done. They will have an exercise stress test and muscle strength tests. Participants will sleep in a specialized room that measures

Accepts healthy volunteers
  • 0 views
  • 10 Aug, 2022
  • 1 location
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives

several genes have been associated with ion channel diseases, but a large number of families do not yet have an identified genetic cause. There is a lack of information on the genetic characteristics of channelopathies in Brazilians affected by these diseases. This study aims to carry out a comprehensive genetic …

  • 0 views
  • 15 Apr, 2021
  • 1 location
Biochemical and Electrocardiographic Signatures in the Detection of Exercise-induced Myocardial Ischemia

The primary aim is to perform the largest study worldwide to evaluate novel biochemical and electrocardiographic signatures alone as well as in combination with the standard 12-lead exercise ECG in the detection of exercise-induced myocardial ischemia (diagnostic endpoint). The secondary aim is to evaluate these innovative tools in the risk …

infarct
artery disease
SPECT Scan
myocardial infarction
exercise ecg
  • 0 views
  • 07 Oct, 2021
  • 1 location