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Found 82 clinical trials
Cadmium-zinc-telluride (CZT) Imaging of Myocardial Blood Flow (MBF) (SPECT MBF) (SPECT MBF)

This study is being done to compare the blood flow measurements obtained with the SPECT and PET imaging scans. Measurements such as myocardial blood flow (MBF) and myocardial flow reserve (MFR) are analyzed on PET scans. These measurements give the doctors more precise information in diagnosing heart problems. SPECT scans, …

Accepts healthy volunteers
ct scan
coronary disease
heart disease
  • 24 Jan, 2022
  • 1 location
Social Stress and Suicide (SUPHY)

Only vulnerable patients, when facing environmental stressors, attempt or commit suicide. Previous research demonstrated that suicide attempters usually misunderstand the social context and show impairments in decision making. Heart activity, endocrine and inflammatory response to stress were related with these features. For that, suicide attempters, in a context of social …

  • 22 Mar, 2022
  • 1 location
The Impact of a Gratitude Intervention on Stress Reactivity

This study will employ a randomized mixed between-within experimental stress-testing protocol design. Physiological responses (blood pressure and pulse) will be recorded throughout a baseline, gratitude induction, standard stress-task and recovery period. Participants will be randomly allocated to the experimental (grateful induction) or control condition (neutral induction). Gratitude will be induced …

Accepts healthy volunteers
  • 09 May, 2022
  • 1 location
Neural Correlates of the Shift in Social Buffering of Social Evaluative Threat

The purpose of this experiment is to determine the mechanisms through which parental buffering of stress physiology in response to social evaluative threat diminishes with pubertal development and whether this diminution of effectiveness extends to social buffering by peers (best friends) and/or other unfamiliar social partners (e.g., experimenters).

Accepts healthy volunteers
  • 23 Apr, 2022
  • 1 location
Acute Effects of Physical Exercise in Patients With Borderline Personality Disorder

The aim of the proposed project is to investigate the effects of a single session of physical exercise on stress regulation, cognitive and emotional functioning, and associated neurophysiological processes (saliva and blood samples) in patients with borderline personality disorder. A further aim is to identify the optimal exercise intensity (moderate …

Accepts healthy volunteers
  • 25 Mar, 2022
  • 1 location
Rehabilitation by Eccentric Exercise in Heart Failure Patients (REX-HF)

As part of the regular rehabilitation program for chronic heart failure (CHF) patients, the addition of dynamic eccentric endurance (ECC) exercise sessions to the conventional concentric cycling program (CON) would enable greater gains in functional capacity that the CON alone. Furthermore, in the case of severe heart failure, results of …

  • 27 Jul, 2022
  • 1 location
Syncope Trial to Understand Tilt Testing Early or Recorders Study (STUTTER)

Pragmatic research study to determine which of the two standard syncope therapies yields a faster path to diagnosis- head up tilt (HUT) table or implantable loop recorder (ILR).

implantable loop recorder
  • 25 Jul, 2022
  • 2 locations
The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion During Exercise in Patients With PAD

Peripheral arterial disease (PAD) is a highly prevalent and costly condition. Intermittent claudication (IC), defined as ischemic leg pain that occurs with walking, results in functional impairment, reduced daily physical activity, and a lower quality of life. Although the mechanisms contributing to functional impairment are not fully delineated, current evidence …

leg pain
intermittent claudication
arterial disease
critical limb ischemia
  • 26 Sep, 2021
  • 1 location
The Association Between Catheter-based Absolute Coronary Flow and Resistance and 15O-H2O Positron Emission Tomography Scan Based Absolute Myocardial Blood Flow in the Coronary Artery Territory

Aims To assess the correlation between absolute flow and resistance assessed by catheter-based thermodilution technique using CoroFlow-system and myocardial blood flow (MBF) measured by positron emission tomography (PET) and the tracer [15O] labeled water ([15O]H2O) (15O-H2O PET) To assess the correlation between impaired MBF measured with 15O-H2O PET and negative …

coronary disease
angina pectoris
  • 31 Jul, 2021
  • 1 location
INvestigation of TENS Efficacy Versus Posterior Tibial Nerve Stimulation for Overactive Bladder (INTENSE)

The objective of this research is to perform a non-masked, non-inferiority randomized controlled trial to assess the quality of life (QOL) of women with idiopathic overactive bladder (OAB) before and after treatment with percutaneous tibial nerve stimulation (PTNS) or transcutaneous electrical nerve stimulation (TENS) of tibial nerve. The target population …

transcutaneous electrical nerve stimulation
percutaneous tibial nerve stimulation
mixed incontinence
conservative therapy
  • 23 Jul, 2022
  • 1 location