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Found 549 clinical trials
Study of the Impact of a Targeted Decolonization of S. Aureus Persistent Carriers (CIBERSTAPH)

S. aureus nasal carriage is a well-known risk factor for S. aureus infections in hemodialysis (HD) patients. Strains of carriage and infections are the same in >80% of cases We recently shown

  • 14 Jun, 2022
  • 9 locations
Seroprevalence of Antibodies to Surface Antigens and Toxins of Clostridioides Difficile (PREVADIFF)

, Kyne et al. showed that after colonization with a toxigenic C. difficile strain, patients with asymptomatic carriage had significantly higher serum levels of IgG directed against toxin A than patients

  • 07 Jul, 2022
  • 1 location
Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator (ICD) Implantation to Prevent Tachyarrhythmias Following Acute Myocardial Infarction (PROTECT-ICD) (PROTECT-ICD)

correlation with (1) inducible VT at EPS and (2) SCD and non-fatal arrhythmia on follow up. It will be used to simultaneously assess left ventricular function, ventricular strain, myocardial infarction size

  • 15 May, 2022
  • 26 locations
Phase 3 Study to Evaluate a Single Booster of the NVX-CoV2373 COVID19 Vaccine in Adults

This is an observer-blinded Phase 3 study to evaluate the safety and immunogenicity of a single booster dose of the Novavax severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recombinant (r) spike (S) protein nanoparticle vaccine adjuvanted with Matrix-MTM (NVX-CoV2373) in adults previously vaccinated with the BBIBP-CorV vaccine. The study will …

Accepts healthy volunteers
  • 10 Apr, 2022
Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults

Cellular and humoral immune responses before and after seasonal influenza vaccination will be assessed. Each year, up to 100 participants will be enrolled. To study age-specific differences in immune responses, participants with various years of birth will be enrolled. The investigators hypothesize that humans with different birth years will mount …

influenza vaccination
trivalent influenza vaccine
Accepts healthy volunteers
  • 14 Nov, 2021
  • 1 location
Prevention of Celiac Disease in Skåne (PreCiSe)

This study aims to investigate the impact on being on a gluten free diet the first three years of life compared to a daily intake of a probiotic supplementation or placebo on the risk of developing celiac disease autoimmunity or celiac disease in genetically susceptible children. Study participants will be …

Accepts healthy volunteers
  • 19 Apr, 2022
  • 1 location
Vectron T500 (Broflanilide 50WP) for IRS in Tanzania Tanzania

Malaria is a major public health problem in Africa. An important way to control the disease is by Indoor Residual Spraying of insecticide in houses. Insecticide resistance has become a major problem. This trial will evaluate a novel insecticide against those insecticide resistant mosquito vectors in Tanzania E Africa.

Accepts healthy volunteers
  • 17 Dec, 2021
  • 2 locations
Efficacy of Family Programs for Improving Child and Family Health and Development

The proposed research is relevant to public health because of the critical importance of infant attachment and early experiences to the lifetime trajectory of mental health and socio-emotional functioning. This Randomized Clinical Trial addresses major gaps in available family-wide programs that can promote healthy development that best serve infants, mothers, …

Accepts healthy volunteers
  • 24 Mar, 2022
  • 2 locations
Non-Steroidal or Opioid Analgesia Use for Children With Musculoskeletal Injuries (No OUCH)

Musculoskeletal (MSK) injuries, including limb injuries, are the most common cause for Emergency Department (ED) visits for children with pain. Broken arms and legs are known to cause moderate to severe pain in most children, yet previous research shows that children's pain in the emergency department is still under-treated. Further, …

  • 08 Jun, 2022
  • 13 locations
Smartphone App to Improve Functional Outcomes in Ankle Sprains (SPRAIN)

Ankle sprains are the most common musculoskeletal complaint of children presenting to the emergency department (ED). Healing can often be protracted, leading to prolonged pain, missed school and

ankle injury
foot injuries
functional recovery
  • 28 Feb, 2022
  • 1 location