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Found 157 clinical trials
A Phase I Study of Bintrafusp Alfa (M7824) and NHS-IL12 (M9241) Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies

without Stereotactic Body Radiation Therapy (SBRT) radiation. Objective To learn if M7824 and M9241, with or without SBRT, can help the immune system to fight cancer

lamivudine
bintrafusp alfa
urine test
entecavir
interferon
  • 0 views
  • 21 Oct, 2022
  • 1 location
Shared Decision Making on Radiation Dose for Lung Malignancies

facilitate their shared decision on the dose of stereotactic body radiation therapy (SBRT) for lung tumors located less than 1 cm from the thoracic wall. Hypothesis: The use of a PtDA will increase

stereotactic body radiation therapy
metastasis
lung carcinoma
  • 0 views
  • 03 Dec, 2021
  • 1 location
Immunotherapy and Chemotherapy in Unresectable Recurrent Loco-regionally Advanced Nasopharyngeal Carcinoma (RETICULA-NPC)

This is an open-label, multi-center, phase II trial to evaluate the safety and efficacy of postponing or omitting re-irradiation after systemic therapy with tislelizumab and chemotherapy in patients with unresectable recurrent loco-regionally advanced nasopharyngeal carcinoma. Patients who did not respond to or progressed on another ICI are allowed to receive …

  • 0 views
  • 19 Apr, 2022
  • 1 location
A Phase II Study Evaluating T-Cell Clonality After Stereotactic Body Radiation Therapy Alone and in Combination With the Immunocytokine M9241 in Localized High and Intermediate Risk Prostate Cancer Treated With Androgen Deprivation Therapy

Background Prostate cancer is often treated with radiation and ADT (ADT is androgen deprivation therapy). Up to 30% of these cancers recur within 5 years of treatment. Researchers want to see if a new drug (M9241) can help the immune system to fight prostate cancer. Objective To find what doses …

  • 0 views
  • 24 Oct, 2022
  • 1 location
SBRT and Durvalumab for Inoperable/Unresectable Hepatocellular Carcinoma

The investigators propose a phase II single-arm study on using stereotactic body radiation therapy in combination with durvalumab for inoperable/unresectable hepatocellular carcinoma. In

pet scan
serum bilirubin
neutrophil count
progressive disease
anticoagulants
  • 0 views
  • 15 Jun, 2021
  • 1 location
Stereotactic Body Radiotherapy (SBRT) for Early Treatment of Oligometastatic Adenoid Cystic Carcinoma: The SOLAR Trial

The aim of this study is to learn whether the early initiation of a specialized and focused type of radiation called stereotactic body radiation therapy (SBRT) will impact the progression of

measurable disease
cancer
  • 0 views
  • 13 Oct, 2022
  • 3 locations
Immunotherapy With or Without SBRT in Patients With Stage IV Non-small Cell Lung Cancer

This phase III trial studies immunotherapy and stereotactic body radiation therapy to see how well it works compared with immunotherapy alone after first-line systemic therapy (therapy that goes

lung cancer
stereotactic radiation
neutrophil count
chemoradiotherapy
stereotactic body radiation
  • 0 views
  • 05 Jun, 2022
  • 1 location
Phase I/II Trial of Anti-CTLA4-NF mAb (BMS-986218) in Combination With Nivolumab and Hypofractionated Stereotactic Radiation Therapy in Patients With Advanced Solid Malignancies

This phase I/II trial studies the side effects of anti-CTLA4-NF monoclonal antibody (mAb) (BMS986218), nivolumab, and stereotactic body radiation therapy in treating patients with solid

  • 16 views
  • 13 Oct, 2022
  • 1 location
SBRT or TACE for Advanced HCC

Randomized study of stereotactic body radiation therapy (SBRT) versus transarterial chemoembolization (TACE) in locally advanced hepatocellular carcinoma.

stereotactic body radiation therapy
TACE
chemoembolization
radiofrequency ablation
coumadin
  • 18 views
  • 09 Dec, 2021
  • 1 location
Stereotactic Hypofractionated Accelerated Radiotherapy Post-Prostatectomy (SHARP)

The present phase I trial evaluates the feasibility of a postoperative stereotactic hypofractionated external beam radiation therapy delivered in patients who underwent radical prostatectomy with adverse pathological features or early biochemical failure. Modern computer-driven technology enables the implementation of ultra-high hypofractionated Image-Guided Radiotherapy (IGRT) safely. Eligible patients for this study …

stereotactic body radiation therapy
positron emission tomography
androgens
choline
MRI
  • 10 views
  • 25 Feb, 2022
  • 1 location