step 2 Clinical Research Trials

Comparison of Dendritic Cell-Based Therapeutic Vaccine Strategies for HIV Functional Cure

This study will be done in people living with HIV to see if an investigational vaccine made from a person's own white blood cells is safe and tolerated. This study will also look at the body's immune response to the vaccine and evaluate four different methods of making the vaccine …

investigational new drug

hysterectomy

tenofovir

white blood cell count

hiv test

32 views
25 Jan, 2021
2 locations

Testing the Addition of Targeted Radiation Therapy to Surgery and the Usual Chemotherapy Treatment (Pemetrexed and Cisplatin [or Carboplatin]) for Stage I-IIIA Malignant Pleural Mesothelioma

This trial studies how well the addition of targeted radiation therapy to surgery and the usual chemotherapy treatment works for the treatment of stage I-IIIA malignant pleural mesothelioma. Targeted radiation therapy such as intensity-modulated radiation therapy or pencil beam scanning uses high energy rays to kill tumor cells and shrink …

0 views
07 Mar, 2021
8 locations

Testing the Addition of the Pill Chemotherapy Cabozantinib to the Standard Immune Therapy Nivolumab Compared to Standard Chemotherapy for Non-small Cell Lung Cancer

This phase II trial compares cabozantinib alone and the combination of cabozantinib and nivolumab to standard chemotherapy in the treatment of patients with non-squamous non-small cell lung cancer (NSCLC). Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal …

hepatitis b

HIV Infection

chronic hepatitis b

neutrophil count

bevacizumab

25 views
07 Mar, 2021
423 locations

Potassium Kinetic During and After Hemodialysis and Potassium Profiling to Prevent Arrhythmias

The primary objective of the study is the development of a mathematical model for predicting potassium kinetics during and after the dialytic session. The secondary objectives of the study are: the definition of a correlation between the kinetics of intra and extra-cellular concentrations of potassium during and after the dialytic …

electrocardiogram

0 views
26 Jan, 2021
1 location

Modification of Gut Microbiota in the Treatment of Insulin Resistance: a Personalized Approach

Gut microbiota may play a key role in many metabolic diseases, including type 2 diabetes (T2D). Consumption of high-fat/high-sugar western diet seem to alter human resident microbiota towards reduced genetic diversity and to influence its metabolic activity towards enhanced energy extraction. Plant-based diets are effective in the treatment of T2D …

0 views
24 Jan, 2021
1 location

Using Technology-Assisted Stepped Care Intervention to Improve Adherence in Adolescents With Asthma

To test the preliminary efficacy of the TASC adherence promotion intervention for adolescents with asthma in a feasibility randomized controlled trial compared to treatment as usual control arm.

corticosteroids

persistent asthma

0 views
24 Jan, 2021
1 location

Mass Balance and Biotransformation of [14C]HSK7653 in Human

A single-center, single-dose, non-randomized, open-label design.

0 views
25 Jan, 2021
1 location

Addictology Expert Patients' Fields of Intervention

Although there are many publications concerning the benefit of the interventions of the self-help movements and peer health mediators in psychiatry, no studies have described the intervention specific to patients with expertise in addictology (EP), nor evaluated their effectiveness. The objective of this study is twofold: identify and define the …

substance use

substance use disorder

addiction

mediators

0 views
25 Jan, 2021
1 location

Ankle Trauma: an Emergency Nurse Assessment Study

The ankle and/or foot injuries incidence is high. Lateral ankle sprains are most common diagnosis, while fractures represent less than 15% of final diagnosis. Ankle and/or foot injuries are associated with significant morbidity in terms of pain and chronic instability. The societal cost of these injuries is significant mainly related …

treatment of ankle

0 views
24 Jan, 2021
1 location

Hand Forceps vs. Conventional One-hand Technique for Fetal Head Extraction During Cesarean Section

The aim of the study is to assess the efficacy and safety of an innovative two-hand (hand forceps) fetal head extraction technique during the transverse cesarean sections (LTCS) by comparing with the conventional one-hand technique used worldwide for centuries. The primary research question of the study is whether two-hand fetal …

cesarean section

0 views
03 Feb, 2021
1 location

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