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Found 74 clinical trials
CD4 CAR+ ZFN-modified T Cells in HIV Therapy

This research study is being carried out to study a new way to possibly treat HIV. As part of this study, doctors will take some of your own white blood cells, called T-cells, and modify them so that they can identify and target your HIV cells. The purpose of the …

hiv-1 infection
hiv-1 rna measurement
hiv test
leukapheresis
hiv therapy
  • 27 views
  • 27 Jan, 2021
  • 1 location
The LATITUDE Study: Long-Acting Therapy to Improve Treatment SUccess in Daily LifE

The purpose of this study is to compare the efficacy, safety, and durability of two different strategies to treat participants with a history of sub-optimal adherence and control of their HIV infection: long-acting (LA) antiretroviral therapy (ART) and all-oral standard of care (SOC).

hiv-1 rna measurement
hiv-1 infection
hiv test
antibody test
local anesthetic
  • 242 views
  • 25 Jan, 2021
  • 33 locations
Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients

This trial studies the side effects of radiation therapy followed by atezolizumab in treating patients with stage II or III non-small cell lung cancer. Hyperfractionated radiation therapy delivers smaller doses of radiation therapy over time and may kill more tumor cells and have fewer side effects. Immunotherapy with monoclonal antibodies, …

major surgery
monoclonal antibodies
monoclonal antibody therapy
tumor cells
other malignancy
  • 0 views
  • 07 Mar, 2021
  • 42 locations
MIRs 04 : Interpectoral Nerve Block With Ropivacaine Versus Placebo Before Breast Cancer Surgery

Compare the effect of ropivacaine versus placebo pectoral nerve block (Pecs 1 and 2) on acute pain after tumorectomy plus sentinel lymph node dissection on one day surgery.

invasive breast cancer
breast carcinoma
breast-conserving surgery
sentinel node
mammogram
  • 0 views
  • 25 Jan, 2021
  • 3 locations
HIV-1 Specific T -Cells (HST-NEETs) for HIV-Infected Individuals

This is a phase I, multi-site, study of the safety, immunologic and virologic responses of ex vivo expanded HIV-1 multi-antigen specific T-cell therapy (HST-NEET) as a therapeutic strategy in HIV-infected individuals suppressed on antiretroviral therapy (ART).

hiv-1 rna measurement
hiv-1 infection
immune globulin
antibody test
antiretroviral agents
  • 18 views
  • 25 Jan, 2021
  • 3 locations
Dual bNAb Treatment in Children

The purpose of this study is to evaluate the impact of two broadly neutralizing antibodies, VRC01LS and 10-1074, on the maintenance of HIV suppression in a cohort of early-treated children in Botswana.

HIV Vaccine
  • 0 views
  • 24 Jan, 2021
  • 2 locations
The BLIMP Balloon in Coronary Interventions

The purpose of this study is to investigate the effectivness of the Blimp Scoring balloon compared to current available CTO balloon catheters.

  • 1 views
  • 23 Jan, 2021
  • 2 locations
Ibrutinib + R-CHOP Followed by Ibrutinib Maintenance

This is a prospective, multicenter, single arm, phase II trial in patients with 18 and <80 years with poor-prognosis (IPI 2) and newly diagnosed ABC-DLBCL. Aim of the study is to assess the efficacy and the safety of R-CHOP in combination with ibrutinib for 6 cycles followed by ibrutinib maintenance …

ibrutinib
platelet count
growth factor
gilbert's syndrome
neutrophil count
  • 0 views
  • 27 Jan, 2021
  • 49 locations
Study to Assess Safety and Activity of Combination Therapy of VRC07-523LS and Vorinostat on HIV-infected Persons

Adult participants (18-64 years old) with HIV-1 Infection on ART with a CD4 T cell count 350 cells/mm3 and viral suppression for 24 months will be enrolled on this study. Participants will receive two series of combination therapy consisting of one (1) intravenous (IV) dose of VRC-HIVMAB075-00-AB (VRC07-523LS) followed by …

  • 1 views
  • 25 Jan, 2021
  • 1 location
Living Donor Liver Transplantation With Two Stage Hepatectomy for Patients With Isolated Irresectable Colorectal Liver Metastases

Nearly one third of patients with colorectal cancer develop liver metastases. It is well known that the achievement of a R0-situation is one of the most important factors for a positive long-term outcome. Despite further advantages in multimodal treatment concepts, only 20 - 30 % of the patients with metastases …

combination therapy
cancer
metastasis
carcinoma
liver metastasis
  • 31 views
  • 23 Jan, 2021
  • 2 locations